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Blood, 1 March 2004, Vol. 103, No. 5, pp. 1735-1740. Prepublished online as a Blood First Edition Paper on November 6, 2003; DOI 10.1182/blood-2003-07-2247. This Article Full Text Full Text (PDF) All Versions of this Article: 2003-07-2247v1 103/5/1735    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Dunn, E. J. Articles by Grant, P. J. Search for Related Content PubMed PubMed Citation Articles by Dunn, E. J. Articles by Grant, P. J. Related Collections Hemostasis, Thrombosis, and Vascular Biology Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY Genetics of fibrin clot structure: a twin study Emma J. Dunn, Robert A. Ariëns, Marlies de Lange, Harold Snieder, John H. Turney, Timothy D. Spector, and Peter J. Grant From the Academic Unit of Molecular Vascular Medicine, General Infirmary, Leeds; the Twin Research and Genetic Epidemiology Unit, St Thomas' Hospital, London, United Kingdom; and the Georgia Prevention Institute, Department of Pediatrics, Medical College of Georgia, Augusta. Coronary artery thrombosis following plaque rupture is an important feature of myocardial infarction, and studies have highlighted the role of coagulation in this condition. Although genetic and environmental influences on the variance in coagulation protein concentrations have been reported, there are no data on the heritability of structure/function of the final phenotype of the coagulation cascade, the fibrin clot. To assess genetic and environmental contributions to fibrin structure, permeation and turbidity studies were performed in 137 twin pairs (66 monozygotic, 71 dizygotic). The environmental influence (e2) on pore size (Ks) (e2 = 0.61 [95% confidence interval (CI), 0.45-0.80]) and fiber size (e2 = 0.54 [95% CI, 0.39-0.73]) was greater than the heritability (h2 = 0.39 [95% CI, 0.20-0.55] and 0.46 [95% CI, 0.27-0.62], respectively). After correction for fibrinogen levels, the environmental effect persisted for Ks (e2 = 0.61), but genetic influence assumed a greater importance in determining fiber size (h2 = 0.73). Multivariate analysis revealed an overlap in the influence of genetic and environmental factors on fibrinogen levels, Ks, and fiber size. Factor XIII B subunit showed environmental and genetic correlation with fibrinogen and fiber size and a genetic correlation with Ks. The results indicate that genetic and environmental influences are important in determining fibrin clot structure/function. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: D. M. O. Pruissen, A. J. C. Slooter, F. R. Rosendaal, Y. van der Graaf, and A. Algra Coagulation factor XIII gene variation, oral contraceptives, and risk of ischemic stroke Blood, February 1, 2008; 111(3): 1282 - 1286. [Abstract] [Full Text] [PDF] R. Ajjan, B. C. B. Lim, K. F. Standeven, R. Harrand, S. Dolling, F. Phoenix, R. Greaves, R. H. Abou-Saleh, S. Connell, D. A. M. Smith, et al. Common variation in the C-terminal region of the fibrinogen -chain: effects on fibrin structure, fibrinolysis and clot rigidity Blood, January 15, 2008; 111(2): 643 - 650. [Abstract] [Full Text] [PDF] A. M. Carter, C. M. Cymbalista, T. D. Spector, P. J. Grant, and on behalf of the EuroCLOT Investigators Heritability of Clot Formation, Morphology, and Lysis: The EuroCLOT Study Arterioscler. Thromb. Vasc. Biol., December 1, 2007; 27(12): 2783 - 2789. [Abstract] [Full Text] [PDF] J. Zalewski, A. Undas, J. Godlewski, E. Stepien, and K. Zmudka No-Reflow Phenomenon After Acute Myocardial Infarction Is Associated With Reduced Clot Permeability and Susceptibility to Lysis Arterioscler. Thromb. Vasc. Biol., October 1, 2007; 27(10): 2258 - 2265. [Abstract] [Full Text] [PDF] J. M. McCaffery, H. Snieder, Y. Dong, and E. de Geus Genetics in Psychosomatic Medicine: Research Designs and Statistical Approaches Psychosom Med, February 1, 2007; 69(2): 206 - 216. [Abstract] [Full Text] [PDF] A. Undas, J. Brozek, M. Jankowski, Z. Siudak, A. Szczeklik, and H. Jakubowski Plasma Homocysteine Affects Fibrin Clot Permeability and Resistance to Lysis in Human Subjects Arterioscler. Thromb. Vasc. Biol., June 1, 2006; 26(6): 1397 - 1404. [Abstract] [Full Text] [PDF] S. Uitte de Willige, M. C. H. de Visser, J. J. Houwing-Duistermaat, F. R. Rosendaal, H. L. Vos, and R. M. Bertina Genetic variation in the fibrinogen gamma gene increases the risk for deep venous thrombosis by reducing plasma fibrinogen {gamma}' levels Blood, December 15, 2005; 106(13): 4176 - 4183. [Abstract] [Full Text] [PDF] E. M. Scott, R. A.S. Ariens, and P. J. Grant Genetic and Environmental Determinants of Fibrin Structure and Function: Relevance to Clinical Disease Arterioscler. Thromb. Vasc. Biol., September 1, 2004; 24(9): 1558 - 1566. [Abstract] [Full Text] [PDF]

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