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Blood, 15 March 2004, Vol. 103, No. 6, pp. 2170-2179.
Prepublished online as a Blood First Edition Paper on November 20, 2003; DOI 10.1182/blood-2003-09-3129.
 Previous Article | Table of Contents | Next Article 
IMMUNOBIOLOGY
Immunodeficiency virus uptake, turnover, and 2-phase transfer in human dendritic cells
Stuart G. Turville,
John J. Santos,
Ines Frank,
Paul U. Cameron,
John Wilkinson,
Monica Miranda-Saksena,
Joanne Dable,
Hella Stössel,
Nikolaus Romani,
Michael Piatak, Jr,
Jeffrey D. Lifson,
Melissa Pope, and
Anthony L. Cunningham
From the Centre For Virus Research, Westmead Millennium Institute, Sydney, Australia; Center for Biomedical Research, Population Council, New York, NY; Department of Microbiology and Immunology, University of Melbourne, Parkville, Australia; the Department of Dermatology and Venereology, University of Innsbruck, Austria; and the AIDS Vaccine Program, Science Applications International Corporation (SAIC)–Frederick, National Cancer Institute at Frederick, Frederick, MD.
HIV-1 subverts antigen processing in dendritic cells (DCs) resulting in viral uptake, infection, and transfer to T cells. Although DCs bound monomeric gp120 and HIV-1 similarly, virus rarely colocalized with endolysosomal markers, unlike gp120, suggesting HIV-1 alters endolysosomal trafficking. Virus within DC intracellular compartments rapidly moved to DC-CD4+ lymphocyte synapses when introduced to CD4+ lymphocyte cultures. Although viral harboring and transfer from nonlysosomal compartments was transient, given DC-associated virus protein, nucleic acids, and infectious HIV-1 transfer to CD4+, lymphocytes decayed within 24 hours. However a second long-term transfer phase was apparent in immature DCs after 48 hours as a zidovudine-sensitive rise in proviral DNA. Therefore, DCs transfer HIV-1 to CD4+ lymphocytes in 2 distinct phases. Immature and mature DCs first divert virus from the endolysosomal pathway to the DC–T-cell synapse. Secondly, the later transfer phase from immature DCs is through de novo HIV-1 production. Thus, the controversy of DCs being infected or not infected for the mechanics of viral transfer to CD4+ lymphocytes can be addressed as a function of time.
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199(8):
1037 - 1040.
[Full Text]
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Q. Hu, I. Frank, V. Williams, J. J. Santos, P. Watts, G. E. Griffin, J. P. Moore, M. Pope, and R. J. Shattock
Blockade of Attachment and Fusion Receptors Inhibits HIV-1 Infection of Human Cervical Tissue
J. Exp. Med.,
April 19, 2004;
199(8):
1065 - 1075.
[Abstract]
[Full Text]
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