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Blood, 15 March 2004, Vol. 103, No. 6, pp. 2257-2265. Prepublished online as a Blood First Edition Paper on November 20, 2003; DOI 10.1182/blood-2003-08-2694. This Article Full Text Full Text (PDF) All Versions of this Article: 2003-08-2694v1 103/6/2257    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Hase, H. Articles by Kobata, T. Search for Related Content PubMed PubMed Citation Articles by Hase, H. Articles by Kobata, T. Related Collections Immunobiology Signal Transduction Gene Expression Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY BAFF/BLyS can potentiate B-cell selection with the B-cell coreceptor complex Hidenori Hase, Yumiko Kanno, Masaru Kojima, Kaoru Hasegawa, Daisuke Sakurai, Hidefumi Kojima, Naoyuki Tsuchiya, Katsushi Tokunaga, Nobuhide Masawa, Miyuki Azuma, Ko Okumura, and Tetsuji Kobata From the Division of Immunology, Institute for Medical Science, and Department of Pathology, Dokkyo University School of Medicine, Tochigi, Japan; Research Center of Fundamental Medicine, International University of Health and Welfare, Tochigi, Japan; Department of Human Genetics, Graduate School of Medicine, the University of Tokyo, Japan; Department of Molecular Immunology, Tokyo Medical and Dental University, Japan; and Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan. The tumor necrosis factor (TNF)–like ligand BAFF/BLyS (B-cell activating factor of the TNF family/B-lymphocyte stimulator) is a potent B-cell survival factor, yet its functional relationship with other B-cell surface molecules such as CD19 and CD40 is poorly understood. We found that follicular dendritic cells (FDCs) in human lymph nodes expressed BAFF abundantly. BAFF up-regulated a B cell–specific transcription factor Pax5/BSAP (Pax5/B cell–specific activator protein) activity and its target CD19, a major component of the B-cell coreceptor complex, and synergistically enhanced CD19 phosphorylation by B-cell antigen receptor (BCR). BAFF further enhanced B-cell proliferation, immunoglobulin G (IgG) production, and reactivity to CD154 by BCR/CD19 coligation and interleukin-15 (IL-15). Our results suggest that BAFF may play an important role in FDC–B-cell interactions through the B-cell coreceptor complex and a possibly sequential link between the T cell–independent and –dependent B-cell responses in the germinal centers. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: M. E. M. El Shikh, R. M. El Sayed, A. K. Szakal, and J. G. Tew T-Independent Antibody Responses to T-Dependent Antigens: A Novel Follicular Dendritic Cell-Dependent Activity J. Immunol., March 15, 2009; 182(6): 3482 - 3491. [Abstract] [Full Text] [PDF] Y. Wu, S. Sukumar, M. E. El Shikh, A. M. Best, A. K. Szakal, and J. G. Tew Immune Complex-Bearing Follicular Dendritic Cells Deliver a Late Antigenic Signal That Promotes Somatic Hypermutation J. Immunol., January 1, 2008; 180(1): 281 - 290. [Abstract] [Full Text] [PDF] N. D. Huntington, R. Tomioka, C. Clavarino, A. M. Chow, D. Linares, P. Mana, J. Rossjohn, T. G. Cachero, F. Qian, S. L. Kalled, et al. A BAFF antagonist suppresses experimental autoimmune encephalomyelitis by targeting cell-mediated and humoral immune responses Int. Immunol., October 1, 2006; 18(10): 1473 - 1485. [Abstract] [Full Text] [PDF] L. Fu, Y.-C. Lin-Lee, L. V. Pham, A. Tamayo, L. Yoshimura, and R. J. Ford Constitutive NF-{kappa}B and NFAT activation leads to stimulation of the BLyS survival pathway in aggressive B-cell lymphomas Blood, June 1, 2006; 107(11): 4540 - 4548. [Abstract] [Full Text] [PDF] J. Ohata, N. J. Zvaifler, M. Nishio, D. L. Boyle, S. L. Kalled, D. A. Carson, and T. J. Kipps Fibroblast-Like Synoviocytes of Mesenchymal Origin Express Functional B Cell-Activating Factor of the TNF Family in Response to Proinflammatory Cytokines J. Immunol., January 15, 2005; 174(2): 864 - 870. [Abstract] [Full Text] [PDF]

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