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 Blood, 15 March 2004, Vol. 103, No. 6, pp. 2404-2406.
Prepublished online as a Blood First Edition Paper on November 13, 2003; DOI 10.1182/blood-2003-08-2692.

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RED CELLS
Brief report

Plasmodium falciparum induces reorganization of host membrane proteins during intraerythrocytic growth

Phillip D. Parker, Leann Tilley, and Nectarios Klonis

From the Department of Biochemistry and the Cooperative Research Center for Diagnostics, La Trobe University, Victoria, Australia.

The virulence of the malaria parasite, Plasmodium falciparum, is due in large part to the way in which it modifies the membrane of its erythrocyte host. In this work we have used confocal microscopy and fluorescence recovery after photo-bleaching to examine the lateral mobility of host membrane proteins in erythrocytes infected with P falciparum at different stages of parasite growth. The erythrocyte membrane proteins band 3 and glycophorin show a marked decrease in mobility during the trophozoite stage of growth. Erythrocytes infected with a parasite strain that does not express the knob-associated histidine-rich protein show similar effects, indicating that this parasite protein does not contribute to the immobilization of the host proteins. Erythrocytes infected with ring-stage parasites exhibit intermediate mobility indicating that the parasite is able to modify its host prior to its active feeding stage.


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