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Blood, 1 April 2004, Vol. 103, No. 7, pp. 2816-2821. Prepublished online as a Blood First Edition Paper on November 6, 2003; DOI 10.1182/blood-2003-07-2524. This Article Full Text Full Text (PDF) All Versions of this Article: 2003-07-2524v1 103/7/2816    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Lou, D.-Q. Articles by Vaulont, S. Search for Related Content PubMed PubMed Citation Articles by Lou, D.-Q. Articles by Vaulont, S. Related Collections Red Cells Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  RED CELLS Functional differences between hepcidin 1 and 2 in transgenic mice Dan-Qing Lou, Gaël Nicolas, Jeanne-Claire Lesbordes, Lydie Viatte, Gisèle Grimber, Marie-France Szajnert, Axel Kahn, and Sophie Vaulont From the Département de Génétique, Développement et Pathologie Moléculaire, Institut Cochin, Institut National de la Santé et de la Recherche Médicale, Centre National de la Recherche Scientifique, et Université René Descartes, Faculté de Médecine Cochin-Port Royal, Paris, France; Institut National de la Santé et de la Recherche Médicale 409, Faculté de Médecine Xavier Bichat, Paris, France. Hepcidin is a 25-amino acid peptide involved in iron homeostasis in mice and humans. It is produced in the liver from a larger precursor, and it is detectable in blood and urine. In contrast to the human genome, which contains only one copy of the gene, the mouse genome contains 2 highly similar hepcidin genes, hepc1 and hepc2, which are, however, considerably divergent at the level of the corresponding mature 25-amino acid peptide. This striking observation led us to ask whether hepc1 and hepc2 performed the same biologic activity with regard to iron metabolism in the mouse. We recently described the severe iron-deficient anemia phenotype in transgenic mice overexpressing hepc1 in the liver. Here we report that, in contrast to the hepc1-transgenic mice, none of the 7 founder hepc2-transgenic animals suffered from anemia. They all developed normally with hematologic parameters similar to the nontransgenic littermates. Hepc2 transgenic mRNA level was found to be very high for all lines compared with the level of hepc1 transgene mRNA necessary to produce severe anemia. These data provide evidence that hepc2 does not act on iron metabolism like hepc1 and give clues for the identification of amino acids important for the iron-regulatory action of the mature 25-amino acid peptide. (Blood. 2004;103:2816-2821) CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: D. Ferring-Appel, M. W. Hentze, and B. Galy Cell-autonomous and systemic context-dependent functions of iron regulatory protein 2 in mammalian iron metabolism Blood, January 15, 2009; 113(3): 679 - 687. [Abstract] [Full Text] [PDF] E. H.J.M. Kemna, H. Tjalsma, H. L. Willems, and D. W. Swinkels Hepcidin: from discovery to differential diagnosis Haematologica, January 1, 2008; 93(1): 90 - 97. [Abstract] [Full Text] [PDF] C. N. Roy, H. H. Mak, I. Akpan, G. Losyev, D. Zurakowski, and N. C. Andrews Hepcidin antimicrobial peptide transgenic mice exhibit features of the anemia of inflammation Blood, May 1, 2007; 109(9): 4038 - 4044. [Abstract] [Full Text] [PDF] N.-B. Nguyen, K. D. Callaghan, A. J. Ghio, D. J. Haile, and F. Yang Hepcidin expression and iron transport in alveolar macrophages Am J Physiol Lung Cell Mol Physiol, September 1, 2006; 291(3): L417 - L425. [Abstract] [Full Text] [PDF] J.-C. Lesbordes-Brion, L. Viatte, M. Bennoun, D.-Q. Lou, G. Ramey, C. Houbron, G. Hamard, A. Kahn, and S. Vaulont Targeted disruption of the hepcidin 1 gene results in severe hemochromatosis Blood, August 15, 2006; 108(4): 1402 - 1405. [Abstract] [Full Text] [PDF] D. D. Harrison-Findik, D. Schafer, E. Klein, N. A. Timchenko, H. Kulaksiz, D. Clemens, E. Fein, B. Andriopoulos, K. Pantopoulos, and J. Gollan Alcohol Metabolism-mediated Oxidative Stress Down-regulates Hepcidin Transcription and Leads to Increased Duodenal Iron Transporter Expression J. Biol. 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Hentze Altered body iron distribution and microcytosis in mice deficient in iron regulatory protein 2 (IRP2) Blood, October 1, 2005; 106(7): 2580 - 2589. [Abstract] [Full Text] [PDF] D F Wallace, L Summerville, P E Lusby, and V N Subramaniam First phenotypic description of transferrin receptor 2 knockout mouse, and the role of hepcidin Gut, July 1, 2005; 54(7): 980 - 986. [Abstract] [Full Text] [PDF]

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