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Blood, 1 April 2004, Vol. 103, No. 7, pp. 2844-2846. Prepublished online as a Blood First Edition Paper on November 26, 2003; DOI 10.1182/blood-2003-09-3094. This Article Full Text Full Text (PDF) All Versions of this Article: 2003-09-3094v1 103/7/2844    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Atichartakarn, V. Articles by Aryurachai, K. Search for Related Content PubMed PubMed Citation Articles by Atichartakarn, V. Articles by Aryurachai, K. Related Collections Red Cells Brief Reports Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  RED CELLS Brief report Correction of hypercoagulability and amelioration of pulmonary arterial hypertension by chronic blood transfusion in an asplenic hemoglobin E/-thalassemia patient Vichai Atichartakarn, Suporn Chuncharunee, Pakorn Chandanamattha, Khanchit Likittanasombat, and Katcharin Aryurachai From the Divisions of Hematology and Cardiology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. Chronic transfusion of packed red blood cells, in addition to other ongoing treatment with warfarin, acetyl salicylic acid, desferrioxamine, and other supportive measures, was given to a splenectomized hemoglobin E/-thalassemia woman with pulmonary arterial hypertension (PHT). Serial measurements of plasma thrombin-antithrombin III complex (TAT) levels and right-sided cardiac catheterization were used to monitor changes after treatment. Reduction of plasma TAT levels from 7.5 to 3.8 µg/L (normal, 3 ± 2.4 µg/L), pulmonary vascular resistance (PVR) from 553.8 to 238.6 dyne.sec.cm-5 (normal, 67 ± 30 dyne.sec.cm-5), and mean pulmonary arterial pressure from 51 to 32 mm Hg (normal, 9 to 19 mm Hg) occurred in tandem. Normalization of blood hypercoagulability as reflected in plasma TAT level by chronic blood transfusion was the likely basis for improvement of increased PVR, being secondary to thrombotic pulmonary arteriopathy and subsequently PHT. (Blood. 2004;103: 2844-2846) CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: E. Vichinsky Hemoglobin E Syndromes Hematology, January 1, 2007; 2007(1): 79 - 83. [Abstract] [Full Text] [PDF] A Phrommintikul, A Sukonthasarn, R Kanjanavanit, and W Nawarawong Splenectomy: a strong risk factor for pulmonary hypertension in patients with thalassaemia Heart, October 1, 2006; 92(10): 1467 - 1472. [Abstract] [Full Text] [PDF] A. Aessopos, D. Farmakis, S. Deftereos, M. Tsironi, S. Tassiopoulos, I. Moyssakis, and M. Karagiorga Thalassemia Heart Disease: A Comparative Evaluation of Thalassemia Major and Thalassemia Intermedia Chest, May 1, 2005; 127(5): 1523 - 1530. [Abstract] [Full Text] [PDF] A. R. Cohen, R. Galanello, D. J. Pennell, M. J. Cunningham, and E. Vichinsky Thalassemia Hematology, January 1, 2004; 2004(1): 14 - 34. [Abstract] [Full Text] [PDF]

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