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Blood, 15 April 2004, Vol. 103, No. 8, pp. 2990-2996. Prepublished online as a Blood First Edition Paper on December 30, 2003; DOI 10.1182/blood-2003-09-3030. This Article Full Text Full Text (PDF) All Versions of this Article: 2003-09-3030v1 103/8/2990    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Perry, S. S. Articles by Spangrude, G. J. Search for Related Content PubMed PubMed Citation Articles by Perry, S. S. Articles by Spangrude, G. J. Related Collections Hematopoiesis and Stem Cells Immunobiology Cell Adhesion and Motility Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  HEMATOPOIESIS L-selectin defines a bone marrow analog to the thymic early T-lineage progenitor S. Scott Perry, Hongfang Wang, L. Jeanne Pierce, Anne Marie Yang, Schickwann Tsai, and Gerald J. Spangrude From the Departments of Medicine and Pathology, University of Utah School of Medicine, Salt Lake City. The recent description of an early T-lineage progenitor (ETP) population in adult mouse thymus implies the presence of a bone marrow predecessor that has not yet been identified. Here we describe a LinNeg Sca-1Pos c-kitHi Thy-1.1Neg L-selectinPos adult mouse bone marrow population that resembles the thymic ETP in both antigen expression phenotype and posttransplantation lineage potential. These cells produce wavelike kinetics of thymic seeding and reconstitute the irradiated thymus with kinetics comparable to a thymocyte graft after intravenous transplantation. Transient B-lineage reconstitution is also observed, but little myeloid potential can be detected in transplant experiments. A second subset of progenitors is L-selectinNeg and is highly enriched for rapid and persistent T- and B-lineage potential, as well as some myeloid potential. L-selectin (CD62L) is therefore an effective marker for separating lymphoid progenitors from myeloid progenitors and hematopoietic stem cells in mouse bone marrow. (Blood. 2004;103: 2990-2996) CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Bridging the bone marrow–thymus gap Markus G. Manz Blood 2004 103: 2869. [Full Text] [PDF] This article has been cited by other articles: S. S. Perry, Y. Zhao, L. Nie, S. W. Cochrane, Z. Huang, and X.-H. 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