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Blood, 15 April 2004, Vol. 103, No. 8, pp. 3117-3121. Prepublished online as a Blood First Edition Paper on December 24, 2003; DOI 10.1182/blood-2003-09-3302. This Article Full Text Full Text (PDF) All Versions of this Article: 2003-09-3302v1 103/8/3117    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Cosmi, L. Articles by Romagnani, S. Search for Related Content PubMed PubMed Citation Articles by Cosmi, L. Articles by Romagnani, S. Related Collections Immunobiology Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY Th2 cells are less susceptible than Th1 cells to the suppressive activity of CD25+ regulatory thymocytes because of their responsiveness to different cytokines Lorenzo Cosmi, Francesco Liotta, Roberta Angeli, Benedetta Mazzinghi, Veronica Santarlasci, Roberto Manetti, Laura Lasagni, Vittorio Vanini, Paola Romagnani, Enrico Maggi, Francesco Annunziato, and Sergio Romagnani From the Department of Internal Medicine, University of Florence, Florence, Italy; Department of Clinical Pathophysiology, Endocrinology Unit, University of Florence, Florence, Italy; and Apuanic Pediatric Hospital, Massa Carrara, Italy. T-cell clones generated from both CD4+CD25+ and CD8+CD25+ human thymocytes were assessed for their ability to suppress the proliferative response to allogeneic stimulation of type 1 T-helper (Th1) or type 2 T-helper (Th2) clones derived from autologous CD4+CD25- thymocytes. Both CD4+ and CD8+ T-regulatory (Treg) cells completely suppressed the proliferation of Th1 clones but exhibited significantly lower suppressive activity on the proliferation of Th2 clones. The partial suppressive effect on Th2 cells was further reduced by the addition in culture of interleukin-4 (IL-4), whereas it was increased in the presence of an anti–IL-4 monoclonal antibody (mAb). The suppressive activity on Th2 clones was also completely inhibited by the addition of IL-7, IL-9, and IL-15 but not of IL-2, whereas the suppressive effect on Th1 clones was only reverted by the addition of IL-15. Of note, Th2 clones expressed significantly higher amounts of mRNA for IL-4 receptor (IL-4R) and IL-9R chains than Th1 clones, whereas the expression of mRNA for IL-2R, IL-7R, and IL-15R chains was comparable. Taken together, these findings demonstrate that Th2 cells have a lower susceptibility than Th1 cells to the suppressive activity of human CD25+ regulatory thymocytes, because they are able to produce, and to respond to, growth factors distinct from IL-2, such as IL-4 and IL-9. (Blood. 2004; 103:3117-3121) CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: E. C. Nowak, C. T. Weaver, H. Turner, S. Begum-Haque, B. Becher, B. Schreiner, A. J. Coyle, L. H. Kasper, and R. J. Noelle IL-9 as a mediator of Th17-driven inflammatory disease J. Exp. Med., July 13, 2009; (2009) jem.20090246v1. 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