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Blood, 1 May 2004, Vol. 103, No. 9, pp. 3549-3551.
Prepublished online as a Blood First Edition Paper on January 15, 2004; DOI 10.1182/blood-2003-08-2734.
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NEOPLASIA
Brief report
Reversal of bone marrow angiogenesis in chronic myeloid leukemia following imatinib mesylate (STI571) therapy
Hans Michael Kvasnicka,
Juergen Thiele,
Peter Staib,
Annette Schmitt-Graeff,
Martin Griesshammer,
Jens Klose,
Knut Engels, and
Susanne Kriener
From the Institute of Pathology and the First Clinic of Medicine, University of Cologne, Germany; Institute of Pathology, University of Freiburg, Germany; Institute of Pathology, University of Frankfurt, Germany; and the Third Clinic of Medicine, University of Ulm, Germany.
The effect of imatinib mesylate (imatinib) therapy on angiogenesis and myelofibrosis was investigated and compared with interferon (IFN) and hydroxyurea (HU) in 98 patients with newly diagnosed Philadelphia chromosome-positive/BCR-ABL+ (Ph+/BCR-ABL+) chronic myeloid leukemia in first chronic phase and no other pretreatment. By means of immunostaining (CD34) and morphometry, a relationship between microvessel frequency and fiber density was detectable in initial bone marrow (BM) biopsies and sequential examinations after at least 8 months of therapy. First-line monotherapy with imatinib induced a significant reduction (normalization in comparison with controls) of microvessels and reticulin fibers. In most patients, decrease in BM vascularity was associated with a complete cytogenetic response. A significant anti-angiogenic effect was also observed after HU treatment, contrasting with IFN administration or combination regimens (IFN plus HU). In conclusion, our data support the anti-angiogenic capacity of imatinib by normalization of vascularity. In contrast, hematologic response following IFN treatment is independent from BM angiogenesis. (Blood. 2004;103:3549-3551)
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