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Blood, 1 May 2004, Vol. 103, No. 9, pp. 3599-3602. Prepublished online as a Blood First Edition Paper on December 30, 2003; DOI 10.1182/blood-2002-11-3568. This Article Full Text Full Text (PDF) All Versions of this Article: 2002-11-3568v1 103/9/3599    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Keen, L. J. Articles by Hows, J. M. Search for Related Content PubMed PubMed Citation Articles by Keen, L. J. Articles by Hows, J. M. Related Collections Immunobiology Transplantation Brief Reports Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  TRANSPLANTATION Brief report Interleukin-10 and tumor necrosis factor alpha region haplotypes predict transplant-related mortality after unrelated donor stem cell transplantation Leigh J. Keen, Todd E. DeFor, Jeffrey L. Bidwell, Stella M. Davies, Benjamin A. Bradley, and Jill M. Hows From the Molecular Immunogenetics Laboratory, Department of Pathology and Microbiology, University of Bristol, Bristol, United Kingdom; Division of Transplantation Sciences, Department of Clinical Medicine, University of Bristol, Bristol, United Kingdom; and Department of Bone Marrow Transplantation and Clinical Research, University of Minnesota, Minneapolis, MN. Certain cytokine gene polymorphisms have been shown to correlate with outcome of human leukocyte antigen (HLA) identical sibling donor stem cell transplantation (SCT), but in unrelated donor SCT such information is scarce. We have studied the association between cytokine gene polymorphism and transplant-related mortality (TRM) in 182 unrelated SCTs performed at a single center. We found association of polymorphism in the tumor necrosis factor alpha (TNF) and interleukin-10 (IL-10) gene and TRM. Both the TNFd4 allele and the TNF -1031C alleles are associated with high risk for TRM. Statistical analysis showed that both polymorphisms were present on a single haplotype. This haplotype was associated with high risk of TRM when present in recipient or donor, 55% (43%-67%) compared with 21% (12%-30%) when absent from both (P < .01). A further allele associated with this haplotype, TNFa5, is also associated with increased risk of TRM. For IL-10, presence of the donor R2-G-C-C haplotype was associated with decreased risk of TRM, 61% (43%-79%) versus 34% (25%-43%), P = .01. In contrast, possession of the R3-G-C-C haplotype by the donor predicted reduced risk of TRM, 30% (19%-41%, 95% CI) versus 53% (40%-66%, 95% CI), P = .01. No independent associations of cytokine polymorphisms with acute graft-versus-host disease were shown. (Blood. 2004;103:3599-3602) CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: M.-T. Lin, B. Storer, P. J. Martin, L.-H. Tseng, B. Grogan, P.-J. Chen, L. P. Zhao, and J. A. Hansen Genetic variation in the IL-10 pathway modulates severity of acute graft-versus-host disease following hematopoietic cell transplantation: synergism between IL-10 genotype of patient and IL-10 receptor {beta} genotype of donor Blood, December 1, 2005; 106(12): 3995 - 4001. [Abstract] [Full Text] [PDF]

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