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Blood, 1 July 2004, Vol. 104, No. 1, pp. 166-169. Prepublished online as a Blood First Edition Paper on March 16, 2004; DOI 10.1182/blood-2003-09-3293. This Article Full Text Full Text (PDF) All Versions of this Article: 2003-09-3293v1 104/1/166    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Suzuki, Y. Articles by Kojima, S. Search for Related Content PubMed PubMed Citation Articles by Suzuki, Y. Articles by Kojima, S. Related Collections Hematopoiesis and Stem Cells Hemostasis, Thrombosis, and Vascular Biology Signal Transduction Brief Reports Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY Brief report Retinoic acid controls blood vessel formation by modulating endothelial and mural cell interaction via suppression of Tie2 signaling in vascular progenitor cells Yasuhiro Suzuki, Yusuke Komi, Hiromi Ashino, Jun Yamashita, Jun Inoue, Atsushi Yoshiki, Anne Eichmann, Hiroshi Amanuma, and Soichi Kojima From the Molecular Cellular Pathology Research Unit and the Laboratory of Molecular Cell Science, RIKEN (The Institute for Physical and Chemical Research), Wako, Saitama, Japan; the Department of Molecular Biology, The Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan; the Laboratory for Stem Cell Differentiation Regulation, Stem Cell Research Center, Institute for Frontier Medical Sciences, Kyoto University, Japan; the ANB Tsukuba Institute, Bioscience Business Center, ALOKA Co Ltd, Niihari, Ibaraki, Japan; the Experimental Animal Division, RIKEN BioResource Center, Tsukuba, Ibaraki, Japan; and INSERM U36, Collège de France, Paris, France. Inhibition by all-trans retinoic acid (atRA) of the microvasculature formation in chicken chorioallantoic membrane (CAM) accompanied remarkably reduced numbers of endothelial cells (ECs) and increased numbers of mural cells (MCs) under the chorionic epithelial layer. Ro41-5253 (retinoid antagonist) exerted the opposite effect. Although atRA did not affect the differentiation of murine embryonic stem cell–derived vascular progenitor cells (VPCs) into ECs or MCs, atRA suppressed EC-MC interaction, leading to impaired branching. In both atRA-treated VPC cultures and CAM tissues underneath the chorionic epithelial layer, the expression of angiopoietin-2 (Ang-2; competitor for Ang-1) was enhanced, whereas that of Tie2 (a receptor for Angs) was reduced. Simultaneous treatment with Ang-1 partially blocked RA induction of EC-MC malinteraction and reduction in blood vessel formation. These results suggest that retinoid(s) may reduce EC-MC interaction by down-regulating Tie2 signaling as well as decreased EC numbers, which lead to impaired vascular remodeling. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: Y. Komi, O. Ohno, Y. Suzuki, M. Shimamura, K. Shimokado, K. Umezawa, and S. Kojima Inhibition of Tumor Angiogenesis by Targeting Endothelial Surface ATP Synthase with Sangivamycin Jpn. J. Clin. Oncol., November 1, 2007; 37(11): 867 - 873. [Abstract] [Full Text] [PDF] D. B. Costa, L. Lozovatsky, P. G. Gallagher, and B. G. Forget A novel splicing mutation of the {alpha}-spectrin gene in the original hereditary pyropoikilocytosis kindred Blood, December 15, 2005; 106(13): 4367 - 4369. [Abstract] [Full Text] [PDF]

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