|
|
Blood, 1 July 2004, Vol. 104, No. 1, pp. 19-25.
Prepublished online as a Blood First Edition Paper on March 18, 2004; DOI 10.1182/blood-2003-12-4162.
 Previous Article | Table of Contents | Next Article 
PLENARY PAPERS
Yolk sac–derived primitive erythroblasts enucleate during mammalian embryogenesis
Paul D. Kingsley,
Jeffrey Malik,
Katherine A. Fantauzzo, and
James Palis
From the Department of Pediatrics, Center for Human Genetics and Molecular Pediatric Disease, University of Rochester Medical Center, Rochester, NY.
The enucleated definitive erythrocytes of mammals are unique in the animal kingdom. The observation that yolk sac–derived primitive erythroid cells in mammals circulate as nucleated cells has led to the conjecture that they are related to the red cells of fish, amphibians, and birds that remain nucleated throughout their life span. In mice, primitive red cells express both embryonic and adult hemoglobins, whereas definitive erythroblasts accumulate only adult hemoglobins. We investigated the terminal differentiation of murine primitive red cells with use of antibodies raised to embryonic  H1-globin. Primitive erythroblasts progressively enucleate between embryonic days 12.5 and 16.5, generating mature primitive erythrocytes that are similar in size to their nucleated counterparts. These enucleated primitive erythrocytes circulate as late as 5 days after birth. The enucleation of primitive red cells in the mouse embryo has not previously been well recognized because it coincides with the emergence of exponentially expanding numbers of definitive erythrocytes from the fetal liver. Our studies establish a new paradigm in the understanding of primitive erythropoiesis and support the concept that primitive erythropoiesis in mice shares many similarities with definitive erythropoiesis of mammals.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
Related Articles in Blood Online:
-
Maturation and enucleation of primitive erythroblasts during mouse embryogenesis is accompanied by changes in cell-surface antigen expression
- Stuart T. Fraser, Joan Isern, and Margaret H. Baron
Blood 2007 109: 343-352.
[Abstract]
[Full Text]
[PDF]
-
Mammalian primitive erythrocytes: neither fish nor fowl
- Joel Anne Chasis
Blood 2004 104: 1-2.
[Full Text]
[PDF]
This article has been cited by other articles:
|
|
|
|
 
H. Bhatia, J. L. Hallock, A. Dutta, S. Karkashon, L. S. Sterner, T. Miyazaki, A. Dean, and J. A. Little
Short-chain fatty acid-mediated effects on erythropoiesis in primary definitive erythroid cells
Blood,
June 18, 2009;
113(25):
6440 - 6448.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S.-J. Lu, Q. Feng, J. S. Park, L. Vida, B.-S. Lee, M. Strausbauch, P. J. Wettstein, G. R. Honig, and R. Lanza
Biologic properties and enucleation of red blood cells from human embryonic stem cells
Blood,
December 1, 2008;
112(12):
4475 - 4484.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Montel-Hagen, L. Blanc, M. Boyer-Clavel, C. Jacquet, M. Vidal, M. Sitbon, and N. Taylor
The Glut1 and Glut4 glucose transporters are differentially expressed during perinatal and postnatal erythropoiesis
Blood,
December 1, 2008;
112(12):
4729 - 4738.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Isern, S. T. Fraser, Z. He, and M. H. Baron
The fetal liver is a niche for maturation of primitive erythroid cells
PNAS,
May 6, 2008;
105(18):
6662 - 6667.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Tober, K. E. McGrath, and J. Palis
Primitive erythropoiesis and megakaryopoiesis in the yolk sac are independent of c-myb
Blood,
March 1, 2008;
111(5):
2636 - 2639.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. E. McGrath, P. D. Kingsley, A. D. Koniski, R. L. Porter, T. P. Bushnell, and J. Palis
Enucleation of primitive erythroid cells generates a transient population of "pyrenocytes" in the mammalian fetus
Blood,
February 15, 2008;
111(4):
2409 - 2417.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. T. Griffin, J. Brennan, and T. Magnuson
The chromatin-remodeling enzyme BRG1 plays an essential role in primitive erythropoiesis and vascular development
Development,
February 1, 2008;
135(3):
493 - 500.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. R. Duselis and P. B. Vrana
Assessment and disease comparisons of hybrid developmental defects
Hum. Mol. Genet.,
April 1, 2007;
16(7):
808 - 819.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. T. Fraser, J. Isern, and M. H. Baron
Maturation and enucleation of primitive erythroblasts during mouse embryogenesis is accompanied by changes in cell-surface antigen expression
Blood,
January 1, 2007;
109(1):
343 - 352.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Soni, S. Bala, B. Gwynn, K. E. Sahr, L. L. Peters, and M. Hanspal
Absence of Erythroblast Macrophage Protein (Emp) Leads to Failure of Erythroblast Nuclear Extrusion
J. Biol. Chem.,
July 21, 2006;
281(29):
20181 - 20189.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. D. Kingsley, J. Malik, R. L. Emerson, T. P. Bushnell, K. E. McGrath, L. A. Bloedorn, M. Bulger, and J. Palis
"Maturational" globin switching in primary primitive erythroid cells
Blood,
February 15, 2006;
107(4):
1665 - 1672.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. H. Chen, Y. Babichev, N. Rodrigues, D. Voskas, L. Ling, V. P. K. H. Nguyen, and D. J. Dumont
Gene expression analysis of Tek/Tie2 signaling
Physiol Genomics,
July 14, 2005;
22(2):
257 - 267.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Delabesse, S. Ogilvy, M. A. Chapman, S. G. Piltz, B. Gottgens, and A. R. Green
Transcriptional Regulation of the SCL Locus: Identification of an Enhancer That Targets the Primitive Erythroid Lineage In Vivo
Mol. Cell. Biol.,
June 15, 2005;
25(12):
5215 - 5225.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Keller
Embryonic stem cell differentiation: emergence of a new era in biology and medicine
Genes & Dev.,
May 15, 2005;
19(10):
1129 - 1155.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
