|
|
Blood, 15 November 2004, Vol. 104, No. 10, pp. 3009-3020.
Prepublished online as a Blood First Edition Paper on July 20, 2004; DOI 10.1182/blood-2004-02-0405.
 Previous Article | Table of Contents | Next Article 
REVIEW ARTICLES
Adult Burkitt leukemia and lymphoma
Kristie A. Blum,
Gerard Lozanski, and
John C. Byrd
From the Division of Hematology and Oncology, The Ohio State University, Columbus; the Division of Pathology, The Ohio State University, Columbus; and the Division of Medicinal Chemistry, Department of Pharmacy, The Ohio State University, Columbus.
The World Health Organization Classification of Lymphoid Neoplasms identifies Burkitt lymphoma/leukemia as a highly aggressive mature B-cell neoplasm consisting of endemic, sporadic, and immunodeficiency-associated variants. These subtypes share many morphologic and immunophenotypic features, but differences exist in their clinical and geographic presentations. All of these subtypes possess chromosomal rearrangements of the c-myc oncogene, the genetic hallmark of Burkitt lymphoma that contributes to lymphomagenesis through alterations in cell cycle regulation, cellular differentiation, apoptosis, cellular adhesion, and metabolism. Brief-duration, high-intensity chemotherapy regimens containing aggressive central nervous system prophylaxis have had remarkable success in the treatment of this disease, with complete remission rates of 75% to 90% and overall survivals reaching 50% to 70% in adults. Although Burkitt lymphoma cells are extremely chemosensitive, biologically targeted therapies should be developed because current treatment options are suboptimal for patients with poor prognostic features or in the setting of relapsed disease.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
D. de Jong
Novel lymphoid neoplasms - the borderland between diffuse large B-cell lymphoma and Burkitt's lymphoma
Haematologica,
July 1, 2009;
94(7):
894 - 896.
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Quijano, A. Lopez, A. Rasillo, S. Barrena, M. Luz Sanchez, J. Flores, C. Fernandez, J. M. Sayagues, C. S. Osuna, N. Fernandez, et al.
Association between the proliferative rate of neoplastic B cells, their maturation stage, and underlying cytogenetic abnormalities in B-cell chronic lymphoproliferative disorders: analysis of a series of 432 patients
Blood,
May 15, 2008;
111(10):
5130 - 5141.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. R. Bhosale, M. Patnana, C. Viswanathan, and J. Szklaruk
The Inguinal Canal: Anatomy and Imaging Features of Common and Uncommon Masses
RadioGraphics,
May 1, 2008;
28(3):
819 - 835.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G Brady, G J MacArthur, and P J Farrell
Epstein Barr virus and Burkitt lymphoma
J. Clin. Pathol.,
December 1, 2007;
60(12):
1397 - 1402.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. Truffinet, E. Pinaud, N. Cogne, B. Petit, L. Guglielmi, M. Cogne, and Y. Denizot
The 3' IgH Locus Control Region Is Sufficient to Deregulate a c-myc Transgene and Promote Mature B Cell Malignancies with a Predominant Burkitt-Like Phenotype
J. Immunol.,
November 1, 2007;
179(9):
6033 - 6042.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Galicier, C. Fieschi, R. Borie, V. Meignin, M.-T. Daniel, L. Gerard, and E. Oksenhendler
Intensive chemotherapy regimen (LMB86) for St Jude stage IV AIDS-related Burkitt lymphoma/leukemia: a prospective study
Blood,
October 15, 2007;
110(8):
2846 - 2854.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Lin and L. J. Medeiros
High-grade B-cell lymphoma/leukemia associated with t(14;18) and 8q24/MYC rearrangement: a neoplasm of germinal center immunophenotype with poor prognosis
Haematologica,
October 1, 2007;
92(10):
1297 - 1301.
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. A. Mertz, R. Kobayashi, and J. P. Dudley
ALY Is a Common Coactivator of RUNX1 and c-Myb on the Type B Leukemogenic Virus Enhancer
J. Virol.,
April 1, 2007;
81(7):
3503 - 3513.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. S. Lam
Treatment of Burkitt's Lymphoma During Pregnancy
Ann. Pharmacother.,
November 1, 2006;
40(11):
2048 - 2052.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Liso, D. Capello, T. Marafioti, E. Tiacci, M. Cerri, V. Distler, M. Paulli, A. Carbone, G. Delsol, E. Campo, et al.
Aberrant somatic hypermutation in tumor cells of nodular-lymphocyte-predominant and classic Hodgkin lymphoma
Blood,
August 1, 2006;
108(3):
1013 - 1020.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. P. Smith, M. L. Bath, D. Metcalf, A. W. Harris, and S. Cory
MYC levels govern hematopoietic tumor type and latency in transgenic mice
Blood,
July 15, 2006;
108(2):
653 - 661.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. A. Ferry
Burkitt's Lymphoma: Clinicopathologic Features and Differential Diagnosis.
Oncologist,
April 1, 2006;
11(4):
375 - 383.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Syed, P. Smith, A. Sullivan, L. C. Spender, M. Dyer, L. Karran, J. O'Nions, M. Allday, I. Hoffmann, D. Crawford, et al.
Transcriptional silencing of Polo-like kinase 2 (SNK/PLK2) is a frequent event in B-cell malignancies
Blood,
January 1, 2006;
107(1):
250 - 256.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. J. Jabbour, S. Faderl, and H. M. Kantarjian
Adult Acute Lymphoblastic Leukemia
Mayo Clin. Proc.,
November 1, 2005;
80(11):
1517 - 1527.
[Abstract]
[PDF]
|
|
|
|
|
|
|
S. T. Lim, R. Karim, B. N. Nathwani, A. Tulpule, B. Espina, and A. M. Levine
AIDS-Related Burkitt's Lymphoma Versus Diffuse Large-Cell Lymphoma in the Pre-Highly Active Antiretroviral Therapy (HAART) and HAART Eras: Significant Differences in Survival With Standard Chemotherapy
J. Clin. Oncol.,
July 1, 2005;
23(19):
4430 - 4438.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Sun, S. Orrenius, S. Pervaiz, and B. Fadeel
Plasma membrane sequestration of apoptotic protease-activating factor-1 in human B-lymphoma cells: a novel mechanism of chemoresistance
Blood,
May 15, 2005;
105(10):
4070 - 4077.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
