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Blood, 15 November 2004, Vol. 104, No. 10, pp. 3190-3197. Prepublished online as a Blood First Edition Paper on July 27, 2004; DOI 10.1182/blood-2004-03-0935. This Article Full Text Full Text (PDF) All Versions of this Article: 2004-03-0935v1 104/10/3190    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Chou, J. Articles by Furie, B. Search for Related Content PubMed PubMed Citation Articles by Chou, J. Articles by Furie, B. Related Collections Hematopoiesis and Stem Cells Hemostasis, Thrombosis, and Vascular Biology Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY Hematopoietic cell-derived microparticle tissue factor contributes to fibrin formation during thrombus propagation Janet Chou, Nigel Mackman, Glenn Merrill-Skoloff, Brian Pedersen, Barbara C. Furie, and Bruce Furie From the Center for Hemostasis and Thrombosis Research, Vascular Biology Center, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston MA; and Departments of Immunology and Cell Biology, Scripps Research Institute, La Jolla CA. Tissue factor (TF) is expressed on nonvascular cells and cells within the vessel wall and circulates in blood associated with microparticles. Although blood-borne TF accumulates into the developing thrombus during thrombus formation, the contribution of blood-borne TF and vessel wall TF to thrombin generation in vivo following vessel injury is unknown. To determine the source and role of blood-borne microparticle TF, we studied arterial thrombus formation in a living mouse using intravital microscopy. Platelet, TF, and fibrin accumulation in the developing thrombus was compared in wild-type and low TF mice. Compared to wild-type mice, low TF mice formed very small platelet thrombi lacking TF or fibrin. Wild-type and low TF mice received transplants of bone marrow from wild-type and low TF mice. Arterial thrombi in low TF bone marrow/wild-type chimeric mice had decreased size and decreased TF and fibrin levels. Arterial thrombi in wild-type bone marrow/low TF chimeric mice showed decreased platelet thrombus size but normal TF and fibrin levels. 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