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Blood, 15 November 2004, Vol. 104, No. 10, pp. 3358-3360. Prepublished online as a Blood First Edition Paper on August 5, 2004; DOI 10.1182/blood-2004-03-1037. This Article Full Text Full Text (PDF) All Versions of this Article: 2004-03-1037v1 104/10/3358    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Bonzheim, I. Articles by Rüdiger, T. Search for Related Content PubMed PubMed Citation Articles by Bonzheim, I. Articles by Rüdiger, T. Related Collections Neoplasia Oncogenes and Tumor Suppressors Signal Transduction Brief Reports Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  NEOPLASIA Brief report Anaplastic large cell lymphomas lack the expression of T-cell receptor molecules or molecules of proximal T-cell receptor signaling Irina Bonzheim, Eva Geissinger, Sabine Roth, Andreas Zettl, Alexander Marx, Andreas Rosenwald, Hans Konrad Müller-Hermelink, and Thomas Rüdiger From the Institute of Pathology, University of Würzburg, Germany Anaplastic large cell lymphoma (ALCL) designates a heterogeneous group of CD30+ (systemic or primary cutaneous) peripheral T-cell lymphomas (PTCLs). A subgroup of systemic ALCL is transformed by anaplastic lymphoma kinase (ALK). We compared 24 ALK+, 15 ALK- systemic, and 7 cutaneous ALCLs with 29 nonanaplastic PTCLs in terms of T-cell receptor (TCR) rearrangements, expression of TCRs and TCR-associated molecules (CD3, ZAP-70 [zeta-associated protein 70]). Despite their frequent clonal rearrangement for TCR, only 2 (4%) of 47 ALCLs expressed TCR protein, whereas TCRs were detected on 27 of 29 nonanaplastic PTCLs. Moreover, both TCR+ ALCLs lacked CD3 and ZAP-70 (ie, molecules indispensable for the transduction of cognate TCR signals). Defective expression of TCRs is a common characteristic of all types of ALCL, which may contribute to the dysregulation of intracellular signaling pathways controlling T-cell activation and survival. This molecular hallmark of ALCL is analogous to defective immunoglobulin expression distinguishing Hodgkin lymphoma from other B-cell lymphomas. (Blood. 2004; 104:3358-3360) CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? 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