Blood online
Home About Blood Authors Subscriptions Permission Advertising Public Access contact us
 

 
Advanced
Current Issue
First Edition
Archives
Submit to Blood
Search
American Society of Hematology
Meeting Abstracts
Email Alerts
 Blood, 15 November 2004, Vol. 104, No. 10, pp. 3386-3392.
Prepublished online as a Blood First Edition Paper on July 13, 2004; DOI 10.1182/blood-2004-03-1155.

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
2004-03-1155v1
104/10/3386    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Right arrow Rights and Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Syrjala, K. L.
Right arrow Articles by Abrams, J. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Syrjala, K. L.
Right arrow Articles by Abrams, J. R.
Related Collections
Right arrow Transplantation
Right arrow Free Research Articles
Right arrow Clinical Trials and Observations
Right arrow Neoplasia
Right arrowRelated Article in Blood Online
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

arrow to previous article Previous Article  |  Table of Contents  |  Next Article next article arrow

TRANSPLANTATION

Neuropsychologic changes from before transplantation to 1 year in patients receiving myeloablative allogeneic hematopoietic cell transplant

Karen L. Syrjala, Sureyya Dikmen, Shelby L. Langer, Sari Roth-Roemer, and Janet R. Abrams

From the Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA; Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle; and the Department of Rehabilitation Medicine, University of Washington School of Medicine, Seattle.

Research indicates that myeloablative hematopoietic cell transplantation (HCT) impairs neurocognitive function. However, prospective studies on long-term effects are lacking. This longitudinal study examined neurocognitive changes over the first year in 142 adult recipients of allogeneic HC transplants who received neuropsychologic testing before transplantation and again after 80 days and 1 year. Age-, sex-, and education-adjusted population-based standardized scores were used for normative comparisons. Performance on all tests declined from before transplantation to 80 days (P < .05) and improved by 1 year (P < .05), returning to pretransplantation levels on all tests except for grip strength and motor dexterity. Although verbal fluency and memory recovered by 1 year, both were below norms at all 3 testing times (P < .01). Logistic regressions indicated that patients without chemotherapy, other than hydroxyurea, previous to HCT and patients not receiving chronic graft-versus-host disease (GVHD) medication at 1 year had lower risk of impaired function (P < .05). In conclusion, HCT was associated with significant generalized decline in neurocognitive performance at 80 days, with subsequent recovery to pretransplantation levels by 1 year for most survivors, except on motor tasks. Results indicate that long-term cognitive decrements, as distinct from motor disabilities, infrequently derive directly from HCT. (Blood. 2004;104:3386-3392)


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?

Related Article in Blood Online:

Cognitive side effects of myeloablative allogeneic hematopoietic cell transplantation
Tim A. Ahles
Blood 2004 104: 3003-3004. [Full Text] [PDF]



This article has been cited by other articles:


Home page
 BloodHome page
K. L. Syrjala, B. F. Kurland, J. R. Abrams, J. E. Sanders, and J. R. Heiman
Sexual function changes during the 5 years after high-dose treatment and hematopoietic cell transplantation for malignancy, with case-matched controls at 5 years
Blood, February 1, 2008; 111(3): 989 - 996.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
J. R. Fann, C. M. Alfano, S. Roth-Roemer, W. J. Katon, and K. L. Syrjala
Impact of Delirium on Cognition, Distress, and Health-Related Quality of Life After Hematopoietic Stem-Cell Transplantation
J. Clin. Oncol., April 1, 2007; 25(10): 1223 - 1231.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
K. L. Syrjala, S. L. Langer, J. R. Abrams, B. E. Storer, and P. J. Martin
Late Effects of Hematopoietic Cell Transplantation Among 10-Year Adult Survivors Compared With Case-Matched Controls
J. Clin. Oncol., September 20, 2005; 23(27): 6596 - 6606.
[Abstract] [Full Text] [PDF]


click for free articles
home about blood authors subscriptions permissions advertising public access contact us
Sponsor: Genentech BioOncology and and Biogen Idec
Blood Online is supported in part by
Genentech BioOncology and Biogen Idec
  Copyright © 2004 by American Society of Hematology         Online ISSN: 1528-0020