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Blood, 15 November 2004, Vol. 104, No. 10, pp. 3400-3407. Prepublished online as a Blood First Edition Paper on July 27, 2004; DOI 10.1182/blood-2004-05-2046. This Article Full Text Full Text (PDF) All Versions of this Article: 2004-05-2046v1 104/10/3400    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Dispenzieri, A. Articles by Gertz, M. A. Search for Related Content PubMed PubMed Citation Articles by Dispenzieri, A. Articles by Gertz, M. A. Related Collections Neoplasia Transplantation Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  TRANSPLANTATION Peripheral blood stem cell transplantation in 16 patients with POEMS syndrome, and a review of the literature Angela Dispenzieri, Alvaro Moreno-Aspitia, Guillermo A. Suarez, Martha Q. Lacy, Gerardo Colon-Otero, Ayalew Tefferi, Mark R. Litzow, Vivek Roy, William J. Hogan, Robert A. Kyle, and Morie A. Gertz From the Division of Hematology and Internal Medicine and the Department of Neurology, Mayo Clinic, Rochester, MN; and the Division of Hematology/Oncology, Mayo Clinic, Jacksonville, FL. POEMS syndrome is characterized by peripheral neuropathy (PN), a clonal plasma cell disorder (PCD), organomegaly, endocrinopathy, skin changes, edema, sclerotic bone lesions, and thrombocytosis. Based on the improved response rates observed with peripheral blood stem cell transplantation (PBSCT) in patients with other PCDs, autologous PBSCT may be an attractive treatment option for this syndrome. Sixteen patients with POEMS syndrome have undergone PBSCT at Mayo. Of these patients, 15 had a severe rapidly progressive sensorimotor PN (9 were wheelchair dependent) and 14 were male. Median age was 51 years (range, 19-62 years). The median number of prior therapies was 3 (range, 0-7). From first symptoms and from diagnosis of POEMS the times to transplantation were 42 months and 5 months (ranges, 8-185 months and 2-149 months), respectively. There were 15 patients who had significantly abnormal pretransplant pulmonary function tests. There was one transplant-related death. During the peritransplant period, 5 patients required intubation for respiratory compromise, including one who required intubation during his stem cell mobilization period. Another patient required noninvasive biphasic positive airway pressure throughout his course. Of the 14 evaluable patients, all have had neurologic improvement or stabilization. Other features have improved substantially. PBSCT for POEMS syndrome is effective therapy but may also be associated with significant morbidity. (Blood. 2004;104:3400-3407) CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: POEMS syndrome: definitions and long-term outcome Angela Dispenzieri, Robert A. Kyle, Martha Q. Lacy, S. Vincent Rajkumar, Terry M. Therneau, Dirk R. Larson, Philip R. Greipp, Thomas E. Witzig, Rita Basu, Guillermo A. Suarez, Rafael Fonseca, John A. Lust, and Morie A. Gertz Blood 2003 101: 2496-2506. [Abstract] [Full Text] [PDF] This article has been cited by other articles: J. S. Allam, C. C. Kennedy, T. R. Aksamit, and A. Dispenzieri Pulmonary Manifestations in Patients With POEMS Syndrome: A Retrospective Review of 137 Patients Chest, April 1, 2008; 133(4): 969 - 974. [Abstract] [Full Text] [PDF] P.-Y. Dietrich and M. A. Duchosal Bevacizumab therapy before autologous stem-cell transplantation for POEMS syndrome Ann. Onc., March 1, 2008; 19(3): 595 - 595. [Full Text] [PDF] A. Dispenzieri, C. J. Klein, and M. L. Mauermann Lenalidomide therapy in a patient with POEMS syndrome Blood, August 1, 2007; 110(3): 1075 - 1076. [Full Text] [PDF] R. Caswell, T. Warner, A. Mehta, and L. Ginsberg POEMS syndrome Practical Neurology, April 1, 2006; 6(2): 111 - 116. [Full Text] [PDF] P. J. Dyck, J. Engelstad, and A. Dispenzieri Vascular endothelial growth factor and POEMS Neurology, January 10, 2006; 66(1): 10 - 12. [Full Text] [PDF] S. Kuwabara, S. Misawa, K. Kanai, Y. Kikkawa, M. Nishimura, C. Nakaseko, R. K. Cho, and T. Hattori Autologous peripheral blood stem cell transplantation for POEMS syndrome Neurology, January 10, 2006; 66(1): 105 - 107. [Abstract] [Full Text] [PDF] D. Pleasure Keeping "Trk" of Paraneoplastic Syndromes Arch Neurol, October 1, 2005; 62(10): 1508 - 1509. [Full Text] [PDF] M. Q. Lacy, W. J. Hogan, M. A. Gertz, A. Dispenzieri, S. V. Rajkumar, S. Hayman, S. Kumar, M. R. Litzow, and A. L. Schroeter Successful Treatment of Scleromyxedema With Autologous Peripheral Blood Stem Cell Transplantation Arch Dermatol, October 1, 2005; 141(10): 1277 - 1282. [Abstract] [Full Text] [PDF] A. Dispenzieri POEMS Syndrome Hematology, January 1, 2005; 2005(1): 360 - 367. [Abstract] [Full Text] [PDF] S. Kuwabara, S. Misawa, K. Kanai, Y. Kikkawa, M. Nishimura, C. Nakaseko, R. K. Cho, and T. Hattori Autologous peripheral blood stem cell transplantation for POEMS syndrome Neurology, January 10, 2006; 66(1): 105 - 107. [Abstract] [Full Text] [PDF]

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