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Blood, 1 December 2004, Vol. 104, No. 12, pp. 3463-3471. Prepublished online as a Blood First Edition Paper on August 3, 2004; DOI 10.1182/blood-2004-03-1067. This Article Full Text Full Text (PDF) All Versions of this Article: 2004-03-1067v1 104/12/3463    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Hess, C. Articles by Luster, A. D. Search for Related Content PubMed PubMed Citation Articles by Hess, C. Articles by Luster, A. D. Related Collections Immunobiology Cell Adhesion and Motility Signal Transduction Chemokines, Cytokines, and Interleukins Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  CHEMOKINES IL-8 responsiveness defines a subset of CD8 T cells poised to kill Christoph Hess, Terry K. Means, Patrick Autissier, Tonia Woodberry, Marcus Altfeld, Marylyn M. Addo, Nicole Frahm, Christian Brander, Bruce D. Walker, and Andrew D. Luster From the Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA; the Howard Hughes Medical Institute, Partners AIDS Research Center, Massachusetts General Hospital and Division of AIDS, Harvard Medical School, Charlestown, MA; and the Division of Viral Pathogenesis, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA. CD8 T cells play a key role in host defense against intracellular pathogens. Efficient migration of these cells into sites of infection is therefore intimately linked to their effector function. The molecular mechanisms that control CD8 T-cell trafficking into sites of infection and inflammation are not well understood, but the chemokine/chemokine receptor system is thought to orchestrate this process. Here we systematically examined the chemokine receptor profile expressed on human CD8 T cells. Surprisingly, we found that CXC chemokine receptor 1 (CXCR1), the predominant neutrophil chemokine receptor, defined a novel interleukin-8/CXC ligand 8 (IL-8/CXCL8)–responsive CD8 T-cell subset that was enriched in perforin, granzyme B, and interferon- (IFN), and had high cytotoxic potential. CXCR1 expression was down-regulated by antigen stimulation both in vitro and in vivo, suggesting antigen-dependent shaping of the migratory characteristics of CD8 T cells. On virus-specific CD8 T cells from persons with a history of Epstein-Barr virus (EBV) and influenza infection, CXCR1 expression was restricted to terminally differentiated effector memory cells. In HIV-1 infection, CXCR1-expressing HIV-1–specific CD8 T cells were present only in persons who were able to control HIV-1 replication during structured treatment interruptions. Thus, CXCR1 identifies a subset of CD8 T cells poised for immediate cytotoxicity and early recruitment into sites of innate immune system activation. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: M. Hsu, S.-Y. Wu, S.-S. Chang, I.-J. Su, C.-H. Tsai, S.-J. Lai, A.-L. Shiau, K. Takada, and Y. Chang Epstein-Barr Virus Lytic Transactivator Zta Enhances Chemotactic Activity through Induction of Interleukin-8 in Nasopharyngeal Carcinoma Cells J. Virol., April 1, 2008; 82(7): 3679 - 3688. [Abstract] [Full Text] [PDF] L. Zheng, C.-n. Njauw, and M. Martins-Green A hCXCR1 transgenic mouse model containing a conditional color-switching system for imaging of hCXCL8/IL-8 functions in vivo J. Leukoc. Biol., November 1, 2007; 82(5): 1247 - 1256. [Abstract] [Full Text] [PDF] D. Winter, J. Moser, E. Kriehuber, C. Wiesner, R. Knobler, F. Trautinger, P. Bombosi, G. Stingl, P. Petzelbauer, A. Rot, et al. Down-Modulation of CXCR3 Surface Expression and Function in CD8+ T Cells from Cutaneous T Cell Lymphoma Patients J. Immunol., September 15, 2007; 179(6): 4272 - 4282. [Abstract] [Full Text] [PDF] D. M. Brainard, A. M. Tager, J. Misdraji, N. Frahm, M. Lichterfeld, R. Draenert, C. Brander, B. D. Walker, and A. D. Luster Decreased CXCR3+ CD8 T Cells in Advanced Human Immunodeficiency Virus Infection Suggest that a Homing Defect Contributes to Cytotoxic T-Lymphocyte Dysfunction J. Virol., August 15, 2007; 81(16): 8439 - 8450. [Abstract] [Full Text] [PDF] M. J. Zilliox, W. J. Moss, and D. E. Griffin Gene Expression Changes in Peripheral Blood Mononuclear Cells during Measles Virus Infection Clin. Vaccine Immunol., July 1, 2007; 14(7): 918 - 923. [Abstract] [Full Text] [PDF] S. A. Islam, S. Y. Thomas, C. Hess, B. D. Medoff, T. K. Means, C. Brander, C. M. Lilly, A. M. Tager, and A. D. Luster The leukotriene B4 lipid chemoattractant receptor BLT1 defines antigen-primed T cells in humans Blood, January 15, 2006; 107(2): 444 - 453. [Abstract] [Full Text] [PDF] O. Gasser, A. Missiou, C. Eken, and C. Hess Human CD8+ T cells store CXCR1 in a distinct intracellular compartment and up-regulate it rapidly to the cell surface upon activation Blood, December 1, 2005; 106(12): 3718 - 3724. [Abstract] [Full Text] [PDF] T. Woodberry, T. J. Suscovich, L. M. Henry, M. August, M. T. Waring, A. Kaur, C. Hess, J. L. Kutok, J. C. Aster, F. Wang, et al. {alpha}E{beta}7 (CD103) Expression Identifies a Highly Active, Tonsil-Resident Effector-Memory CTL Population J. Immunol., October 1, 2005; 175(7): 4355 - 4362. [Abstract] [Full Text] [PDF]

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