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Blood, 15 December 2004, Vol. 104, No. 13, pp. 4002-4009. Prepublished online as a Blood First Edition Paper on May 25, 2004; DOI 10.1182/blood-2004-02-0494. This Article Full Text Full Text (PDF) Supplemental Figure All Versions of this Article: 2004-02-0494v1 104/13/4002    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Gricks, C. S. Articles by Gribben, J. G. Search for Related Content PubMed PubMed Citation Articles by Gricks, C. S. Articles by Gribben, J. G. Related Collections Immunobiology Neoplasia Signal Transduction Gene Expression Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY Differential regulation of gene expression following CD40 activation of leukemic compared to healthy B cells Clair S. Gricks, David Zahrieh, A. Jason Zauls, Gullu Gorgun, Daniela Drandi, Katja Mauerer, Donna Neuberg, and John G. Gribben From the Departments of Medical Oncology and Biostatistical Science, Dana-Farber Cancer Institute, Department of Medicine Brigham and Women's Hospital, Harvard Medical School, Boston MA. It is possible to differentiate malignant from healthy cells and to classify diseases based on identification of specific gene expression profiles. We hypothesized that gene expression profiling could also be used to identify differential activation of healthy and malignant cells, and as a model for this, we examined the molecular sequelae of CD40 activation of healthy and B-cell chronic lymphocytic leukemia (CLL) cells. Hierarchical clustering analysis of gene expression signatures grouped samples by CD40 activation status and further subclassified CD40-activated CLL cells from healthy B cells. Supervised analyses in healthy B cells compared to CLL cells identified differential regulation of genes governing cell cycle progression and apoptosis. CD40 signaling of CLL cells increases their susceptibility to immune recognition, but promotes survival and cell cycle arrest, making these cells potentially more resistant to chemotherapy. These results illustrate the utility of gene expression profiling to elucidate the molecular sequelae of signaling in healthy cells and altered signaling pathways in malignant cells. This type of approach should be useful to identify targets of therapy of malignant diseases. (Blood. 2004;104:4002-4009) CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: All B cells are not the same: a story of CD40 activation John C. Byrd Blood 2004 104: 3847. [Full Text] [PDF] This article has been cited by other articles: R. Proto-Siqueira, R. A. Panepucci, F. P. Careta, A. Lee, A. Clear, K. Morris, C. Owen, E. G. Rizzatti, W. A. Silva Jr, R. P. Falcao, et al. SAGE analysis demonstrates increased expression of TOSO contributing to Fas-mediated resistance in CLL Blood, July 15, 2008; 112(2): 394 - 397. [Abstract] [Full Text] [PDF] A. Troeger, I. Schmitz, M. Siepermann, L. Glouchkova, U. Gerdemann, G. E. Janka-Schaub, K. Schulze-Osthoff, and D. Dilloo Up-regulation of c-FLIPS+R upon CD40 stimulation is associated with inhibition of CD95-induced apoptosis in primary precursor B-ALL Blood, July 1, 2007; 110(1): 384 - 387. [Abstract] [Full Text] [PDF] N. D. Mineva, T. L. Rothstein, J. A. Meyers, A. Lerner, and G. E. Sonenshein CD40 Ligand-mediated Activation of the de Novo RelB NF-{kappa}B Synthesis Pathway in Transformed B Cells Promotes Rescue from Apoptosis J. Biol. Chem., June 15, 2007; 282(24): 17475 - 17485. [Abstract] [Full Text] [PDF] L. D. Vallat, Y. Park, C. Li, and J. G. Gribben Temporal genetic program following B-cell receptor cross-linking: altered balance between proliferation and death in healthy and malignant B cells Blood, May 1, 2007; 109(9): 3989 - 3997. [Abstract] [Full Text] [PDF] L. A. Smit, D. Y.H. Hallaert, R. Spijker, B. de Goeij, A. Jaspers, A. P. Kater, M. H.J. van Oers, C. J.M. van Noesel, and E. Eldering Differential Noxa/Mcl-1 balance in peripheral versus lymph node chronic lymphocytic leukemia cells correlates with survival capacity Blood, February 15, 2007; 109(4): 1660 - 1668. [Abstract] [Full Text] [PDF] P. Secchiero, E. Barbarotto, A. Gonelli, M. Tiribelli, C. Zerbinati, C. Celeghini, C. Agostinelli, S. A. Pileri, and G. Zauli Potential Pathogenetic Implications of Cyclooxygenase-2 Overexpression in B Chronic Lymphoid Leukemia Cells Am. J. Pathol., December 1, 2005; 167(6): 1599 - 1607. [Abstract] [Full Text] [PDF]

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