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Blood, 15 December 2004, Vol. 104, No. 13, pp. 4038-4045. Prepublished online as a Blood First Edition Paper on August 10, 2004; DOI 10.1182/blood-2004-03-1140. This Article Full Text Full Text (PDF) All Versions of this Article: 2004-03-1140v1 104/13/4038    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Herre, J. Articles by Brown, G. D. Search for Related Content PubMed PubMed Citation Articles by Herre, J. Articles by Brown, G. D. Related Collections Immunobiology Phagocytes Signal Transduction Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY Dectin-1 uses novel mechanisms for yeast phagocytosis in macrophages Jurgen Herre, Andrew S. J. Marshall, Emmanuelle Caron, Alexander D. Edwards, David L. Williams, Edina Schweighoffer, Victor Tybulewicz, Caetano Reis e Sousa, Siamon Gordon, and Gordon D. Brown From the Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom; Centre for Molecular Microbiology and Infection and Department of Biological Sciences, Imperial College, London, United Kingdom; Immunobiology Laboratory, Cancer Research United Kingdom, London, United Kingdom; Department of Surgery, James H. Quillen College of Medicine, Johnson City, TN; National Institute for Medical Research, The Ridgeway, Mill Hill, London, United Kingdom; and Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Rondebosch, South Africa. The phagocytosis of pathogens is a critical event in host defense, not only for clearance of the invading microorganism, but also for the subsequent immune response. We have examined Dectin-1, a proinflammatory nonopsonic receptor for -glucans, and show that it mediates the internalization of -glucan-bearing ligands, including yeast particles. Although requiring tyrosine phosphorylation and the cytoplasmic immunoreceptor tyrosine-based activation motif (ITAM)-like motif, uptake mediated by Dectin-1 was different from any previously reported phagocytic receptor and was not dependent on Syk-kinase in macrophages. Furthermore, intracellular trafficking of this receptor was influenced by the nature of the -glucan ligand, which has significance for the biologic activity of these immunomodulatory carbohydrates. (Blood. 2004;104:4038-4045) CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Dectin-1: unique appetite for yeast Cees van Kooten Blood 2004 104: 3846. [Full Text] [PDF] This article has been cited by other articles: H. Huang, G. R. Ostroff, C. K. Lee, J. P. Wang, C. A. Specht, and S. M. Levitz Distinct Patterns of Dendritic Cell Cytokine Release Stimulated by Fungal {beta}-Glucans and Toll-Like Receptor Agonists Infect. Immun., May 1, 2009; 77(5): 1774 - 1781. [Abstract] [Full Text] [PDF] B. Balestrieri, A. Maekawa, W. Xing, M. H. Gelb, H. R. Katz, and J. P. Arm Group V Secretory Phospholipase A2 Modulates Phagosome Maturation and Regulates the Innate Immune Response against Candida albicans J. 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