|
|
Blood, 15 December 2004, Vol. 104, No. 13, pp. 4165-4172.
Prepublished online as a Blood First Edition Paper on August 24, 2004; DOI 10.1182/blood-2004-06-2484.
 Previous Article | Table of Contents | Next Article 
IMMUNOBIOLOGY
Dynamic regulation of IL-7 receptor expression is required for normal thymopoiesis
Ivana Munitic,
Joy A. Williams,
Yili Yang,
Bei Dong,
Philip J. Lucas,
Nahed El Kassar,
Ronald E. Gress, and
Jonathan D. Ashwell
From the Laboratory of Immune Cell Biology, National Cancer Institute, National Institutes of Health; Division of Therapeutic Proteins, Center for Biologics Evaluation and Research, Food and Drug Administration; and the Experimental Immunology Branch, National Cancer Institute, Bethesda, MD.
Interleukin-7 receptor (IL-7R) levels are tightly controlled during ontogeny: high on double-negative (DN) cells, absent on double-positive (DP) cells, and high once again on thymocytes undergoing positive selection. To determine if loss of IL-7–mediated survival signals in DP cells is necessary for normal antigen-specific selection, we created T-lineage–specific IL-7R  chain (IL-7R) transgenic (Tg) mice in which IL-7R is expressed throughout ontogeny. There was no effect of the IL-7R Tg on negative selection. Surprisingly, however, although the thymi of IL-7R Tg mice were comparable at birth, there was a decrease in thymocyte number as the mice aged. This was found to be due to competition between DN and IL-7R–expressing DP cells for endogenous IL-7, which resulted in decreased levels of Bcl-2 in DN cells, increased DN apoptosis, and decreased DN cell number. Therefore, the down-regulation of IL-7R on DP cells is an "altruistic" act required for maintaining an adequate supply of local IL-7 for DN cells.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
Related Article in Blood Online:
-
IL-7: a limited resource during thymopoiesis
- Thomas R. Malek
Blood 2004 104: 3842.
[Full Text]
[PDF]
This article has been cited by other articles:
|
|
|
|
 
M. Lavanya, S. Kinet, A. Montel-Hagen, C. Mongellaz, J.-L. Battini, M. Sitbon, and N. Taylor
Cell Surface Expression of the Bovine Leukemia Virus-Binding Receptor on B and T Lymphocytes Is Induced by Receptor Engagement
J. Immunol.,
July 15, 2008;
181(2):
891 - 898.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. S. Haring, X. Jing, J. Bollenbacher-Reilley, H.-H. Xue, W. J. Leonard, and J. T. Harty
Constitutive Expression of IL-7 Receptor {alpha} Does Not Support Increased Expansion or Prevent Contraction of Antigen-Specific CD4 or CD8 T Cells following Listeria monocytogenes Infection
J. Immunol.,
March 1, 2008;
180(5):
2855 - 2862.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Egawa, R. E. Tillman, Y. Naoe, I. Taniuchi, and D. R. Littman
The role of the Runx transcription factors in thymocyte differentiation and in homeostasis of naive T cells
J. Exp. Med.,
August 6, 2007;
204(8):
1945 - 1957.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. S. Albuquerque, C. S. Cortesao, R. B. Foxall, R. S. Soares, R. M. M. Victorino, and A. E. Sousa
Rate of Increase in Circulating IL-7 and Loss of IL-7R{alpha} Expression Differ in HIV-1 and HIV-2 Infections: Two Lymphopenic Diseases with Similar Hyperimmune Activation but Distinct Outcomes
J. Immunol.,
March 1, 2007;
178(5):
3252 - 3259.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Yu and T. R. Malek
Selective Availability of IL-2 Is a Major Determinant Controlling the Production of CD4+CD25+Foxp3+ T Regulatory Cells
J. Immunol.,
October 15, 2006;
177(8):
5115 - 5121.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. J. Fry
IL-7 comes of age
Blood,
April 1, 2006;
107(7):
2587 - 2588.
[Full Text]
[PDF]
|
|
|
|
|
|
|
Q. Yu, J.-H. Park, L. L. Doan, B. Erman, L. Feigenbaum, and A. Singer
Cytokine signal transduction is suppressed in preselection double-positive thymocytes and restored by positive selection
J. Exp. Med.,
January 23, 2006;
203(1):
165 - 175.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. G. Radu, D. Cheng, A. Nijagal, M. Riedinger, J. McLaughlin, L. V. Yang, J. Johnson, and O. N. Witte
Normal Immune Development and Glucocorticoid-Induced Thymocyte Apoptosis in Mice Deficient for the T-Cell Death-Associated Gene 8 Receptor
Mol. Cell. Biol.,
January 15, 2006;
26(2):
668 - 677.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Penkov, P. Di Rosa, L. Fernandez Diaz, V. Basso, E. Ferretti, F. Grassi, A. Mondino, and F. Blasi
Involvement of Prep1 in the {alpha}{beta} T-Cell Receptor T-Lymphocytic Potential of Hematopoietic Precursors
Mol. Cell. Biol.,
December 15, 2005;
25(24):
10768 - 10781.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. J. Fry and C. L. Mackall
The Many Faces of IL-7: From Lymphopoiesis to Peripheral T Cell Maintenance
J. Immunol.,
June 1, 2005;
174(11):
6571 - 6576.
[Abstract]
[Full Text]
[PDF]
|
|
|
| |
