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Blood, 15 July 2004, Vol. 104, No. 2, pp. 314-320. Prepublished online as a Blood First Edition Paper on March 25, 2004; DOI 10.1182/blood-2003-08-2891. This Article Full Text Full Text (PDF) All Versions of this Article: 2003-08-2891v1 104/2/314    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Øynebråten, I. Articles by Haraldsen, G. Search for Related Content PubMed PubMed Citation Articles by Øynebråten, I. Articles by Haraldsen, G. Related Collections Hemostasis, Thrombosis, and Vascular Biology Chemokines, Cytokines, and Interleukins Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  CHEMOKINES Rapid chemokine secretion from endothelial cells originates from 2 distinct compartments Inger Øynebråten, Oddmund Bakke, Per Brandtzaeg, Finn-Eirik Johansen, and Guttorm Haraldsen From the Laboratory for Immunohistochemistry and Immunopathology (LIIPAT), Institute of Pathology, University of Oslo; Department of Pathology, Rikshospitalet University Hospital; and Section for Biochemistry and Molecular Biology (IBMB), Faculty of Medicine, University of Bergen, Norway. The neutrophil-attracting chemokine interleukin 8 (IL-8) is stored in the Weibel-Palade body (WPB) of endothelial cells (ECs) from which it can be rapidly released after exposure to the secretagogues histamine or thrombin. In this manner, IL-8 may enable rapid recruitment of leukocytes to inflammatory sites. To explore the possible storage of EC-derived chemokines that may attract other subsets of leukocytes, we examined the intracellular localization and secretagogue responsiveness of growth-related oncogene (GRO), monocyte chemoattractant protein-1 (MCP-1), eotaxin-3, interferon--inducible protein 10 (IP-10), and regulated on activation, normal T-cell expressed and secreted (RANTES). While eotaxin-3, GRO, and MCP-1 were rapidly released from ECs, the release of the T-cell attractors RANTES and IP-10 was not sensitive to the secretagogues. Moreover, of the 3 former chemokines, only eotaxin-3 was stored in WPBs. GRO and MCP-1 resided mainly in smaller vesicles compatible with sorting to a different, histamine-responsive compartment, which has been described in ECs although not reported to contain chemokines. In conclusion, we propose that rapid release of chemokines is restricted to those primarily recruiting leukocytes of the innate immune system, and that their storage in ECs is not restricted to the WPB compartment. (Blood. 2004;104:314-320) CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: D. Chen, A. Carpenter, J. Abrahams, R. C. Chambers, R. I. Lechler, J. H. McVey, and A. Dorling Protease-activated receptor 1 activation is necessary for monocyte chemoattractant protein 1-dependent leukocyte recruitment in vivo J. Exp. Med., July 7, 2008; (2008) jem.20071427. [Abstract] [Full Text] [PDF] B. J. Bhattacharyya, G. Banisadr, H. Jung, D. Ren, D. G. Cronshaw, Y. Zou, and R. J. Miller The Chemokine Stromal Cell-Derived Factor-1 Regulates GABAergic Inputs to Neural Progenitors in the Postnatal Dentate Gyrus J. Neurosci., June 25, 2008; 28(26): 6720 - 6730. [Abstract] [Full Text] [PDF] S.-Y. Chou, J.-Y. 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