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Blood, 15 July 2004, Vol. 104, No. 2, pp. 374-379. Prepublished online as a Blood First Edition Paper on February 26, 2004; DOI 10.1182/blood-2003-12-4304. This Article Full Text Full Text (PDF) All Versions of this Article: 2003-12-4304v1 104/2/374    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Henckaerts, E. Articles by Snoeck, H.-W. Search for Related Content PubMed PubMed Citation Articles by Henckaerts, E. Articles by Snoeck, H.-W. Related Collections Hematopoiesis and Stem Cells Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  HEMATOPOIESIS Quantitative genetic variation in the hematopoietic stem cell and progenitor cell compartment and in lifespan are closely linked at multiple loci in BXD recombinant inbred mice Els Henckaerts, Jessica C. Langer, and Hans-Willem Snoeck From the Carl C. Icahn Center for Gene Therapy and Molecular Medicine, Mount Sinai School of Medicine, New York, NY. The number of bone marrow hematopoietic stem and progenitor cells as defined by the lineage-, Sca1++, c-kit+ (LSK) phenotype and their proliferative capacity in vitro are subject to quantitative genetic variation, and several quantitative trait loci (QTL) have been identified in young mice. Because some traits affecting hematopoiesis also change with age in a mouse strain-dependent fashion, we performed quantitative trait analysis in aged BXD recombinant inbred (RI) mice for the number and frequency of LSK cells, and for their proliferative capacity in vitro. Several novel QTL were identified. The number and frequency of LSK cells in old mice correlated inversely with lifespan. Furthermore, 4 of 7 lifespan QTL overlap with QTL contributing to the number, frequency, or proliferative capacity of LSK cells in young or old mice. Taken together, these data establish a close genetic, and perhaps functional, link between genetic variation in lifespan and characteristics of stem and progenitor cells. (Blood. 2004;104:374-379) CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: R. H. Cho, H. B. Sieburg, and C. E. Muller-Sieburg A new mechanism for the aging of hematopoietic stem cells: aging changes the clonal composition of the stem cell compartment but not individual stem cells Blood, June 15, 2008; 111(12): 5553 - 5561. [Abstract] [Full Text] [PDF] H. B. Sieburg, R. H. Cho, B. Dykstra, N. Uchida, C. J. Eaves, and C. E. Muller-Sieburg The hematopoietic stem compartment consists of a limited number of discrete stem cell subsets Blood, March 15, 2006; 107(6): 2311 - 2316. [Abstract] [Full Text] [PDF] Y. Liang, G. Van Zant, and S. J. Szilvassy Effects of aging on the homing and engraftment of murine hematopoietic stem and progenitor cells Blood, August 15, 2005; 106(4): 1479 - 1487. [Abstract] [Full Text] [PDF] H. Geiger, G. Rennebeck, and G. Van Zant Regulation of hematopoietic stem cell aging in vivo by a distinct genetic element PNAS, April 5, 2005; 102(14): 5102 - 5107. [Abstract] [Full Text] [PDF]

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