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Blood, 15 July 2004, Vol. 104, No. 2, pp. 402-408. Prepublished online as a Blood First Edition Paper on March 25, 2004; DOI 10.1182/blood-2003-08-2974. This Article Full Text Full Text (PDF) All Versions of this Article: 2003-08-2974v1 104/2/402    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Álvarez, A. Articles by Sanz, M.-J. Search for Related Content PubMed PubMed Citation Articles by Álvarez, A. Articles by Sanz, M.-J. Related Collections Hemostasis, Thrombosis, and Vascular Biology Cell Adhesion and Motility Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY Direct evidence of leukocyte adhesion in arterioles by angiotensin II Ángeles Álvarez, Miguel Cerdá-Nicolás, Yafa Naim Abu Nabah, Manuel Mata, Andrew C. Issekutz, Julián Panés, Roy R. Lobb, and Maria-Jesus Sanz From the Departments of Pharmacology and Pathology, Faculty of Medicine, University of Valencia, Spain; Departments of Pediatrics, Pathology, Microbiology, and Immunology, Dalhousie University, Halifax, NS, Canada; Gastroenterology Department, Institut Clínic de Malalties Digestives, Institut d'Investigació Biomèdica August Pi i Sunyer (IDIBAPS), Hospital Clinic, Barcelona, Spain; and Biogen Inc, Cambridge, MA. Although leukocytes adhere in arteries in various vascular diseases, to date no endogenous proinflammatory molecule has been identified to initiate leukocyte adhesion in the arterial vasculature. This study was undertaken to assess angiotensin II (Ang II)-induced leukocyte adhesion in arterioles in vivo. Rats received intraperitoneal injections of Ang II; 4 hours later, leukocyte recruitment in mesenteric microcirculation was examined using intravital microscopy. Ang II (1 nM) produced significant arteriolar leukocyte adhesion of mononuclear cells. Using function-blocking monoclonal antibodies (mAbs) against different rat cell adhesion molecules (CAMs), we discovered that this effect was dependent on P-selectin and 2-integrin. In postcapillary venules, Ang II also induced leukocyte infiltration, which was reduced by P-selectin and by 2- and 4-integrin blockade. Interestingly, neutrophils were the primary cells recruited in venules. Although 2-integrin expression in peripheral leukocytes of Ang II-treated animals was not altered, it was increased in peritoneal cells. Immunohistochemical studies revealed increased P-selectin, E-selectin, intercellular cell adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1) expression in response to Ang II in arterioles and venules. These findings provide the first evidence that Ang II causes leukocyte adhesion to the arterial endothelium in vivo at physiologically relevant doses. Therefore, Ang II may be a key molecule in cardiovascular diseases in which leukocyte adhesion to the arteries is a characteristic feature. (Blood. 2004;104:402-408) CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: S. Yagi, K.-i. Aihara, Y. Ikeda, Y. Sumitomo, S. Yoshida, T. Ise, T. Iwase, K. Ishikawa, H. Azuma, M. Akaike, et al. 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