|
|
Blood, 15 July 2004, Vol. 104, No. 2, pp. 470-477.
Prepublished online as a Blood First Edition Paper on April 1, 2004; DOI 10.1182/blood-2003-12-4265.
 Previous Article | Table of Contents | Next Article 
IMMUNOBIOLOGY
De novo T-cell generation in patients at different ages and stages of HIV-1 disease
Massimo Nobile,
Rafael Correa,
José A. M. Borghans,
Claudia D'Agostino,
Philippe Schneider,
Rob J. de Boer, and
Giuseppe Pantaleo, for the Swiss HIV Cohort Study
From the Laboratory of AIDS Immunopathogenesis, Division of Immunology and Allergy, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland; Laboratory of Molecular Immuno-Biology, Hospital General Universitario Gregorio Marañón (HGUGM), Madrid, Spain; Department of Clinical Viro-Immunology, Sanquin Research at Centraal Laboratorium van de Bloedtransfusiedienst van het Nederlandse Rode Kruis (CLB) and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, The Netherlands; Service Régional Vaudois de Transfusion Sanguine, Lausanne, Switzerland; and Theoretical Biology, Utrecht University, The Netherlands.
We assessed de novo T-cell generation by determining T-cell receptor-rearrangement excision circles (TRECs) based on patient age and on stage of HIV-1 infection. TRECs were measured in purified CD4 and CD8 T cells of a large cohort of HIV-1-infected subjects (n = 297) with chronic infection but no previous antiretroviral treatment and of a control group of HIV-negative subjects (n = 120). HIV-1-infected subjects were stratified on the basis of CD4 T-cell counts in 3 groups, early-stage disease (more than 500 CD4 T cells), intermediate-stage disease (200-500 CD4 T cells), and late-stage disease (fewer than 200 CD4 T cells). Compared with the control group, CD8 TREC contents were severely reduced (P < .001) in HIV-1-infected subjects regardless of the stage of HIV disease. In contrast, CD4 TREC contents were significantly increased (P = .003) in HIV-1-infected subjects during early-stage disease, similar at intermediate-stage disease, and severely reduced only at late-stage disease. We show that the increase in CD4 TRECs was mostly limited to younger (younger than 45 years) patients at early-stage disease. Our results demonstrate a dichotomy between TREC contents in CD4 and CD8 T-cell populations in HIV-1 infection and indicate that thymus function in younger subjects is preserved at early and intermediate stages of HIV infection. (Blood. 2004;104:470-477)
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
M. J. Miguez-Burbano, J. E. Lewis, J. Fishman, D. Asthana, and R. M. Malow
The Influence of Different Types of Alcoholic Beverages on Disrupting Highly Active Antiretroviral Treatment (HAART) Outcome
Alcohol Alcohol.,
July 1, 2009;
44(4):
366 - 371.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. L. Whiteside, P. Piazza, A. Reiter, J. Stanson, N. C. Connolly, C. R. Rinaldo Jr., and S. A. Riddler
Production of a Dendritic Cell-Based Vaccine Containing Inactivated Autologous Virus for Therapy of Patients with Chronic Human Immunodeficiency Virus Type 1 Infection
Clin. Vaccine Immunol.,
February 1, 2009;
16(2):
233 - 240.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Kohler and A. Thiel
Life after the thymus: CD31+ and CD31- human naive CD4+ T-cell subsets
Blood,
January 22, 2009;
113(4):
769 - 774.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. D. Kilpatrick, T. Rickabaugh, L. E. Hultin, P. Hultin, M. A. Hausner, R. Detels, J. Phair, and B. D. Jamieson
Homeostasis of the Naive CD4+ T Cell Compartment during Aging
J. Immunol.,
February 1, 2008;
180(3):
1499 - 1507.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Delobel, M.-T. Nugeyre, M. Cazabat, K. Sandres-Saune, C. Pasquier, L. Cuzin, B. Marchou, P. Massip, R. Cheynier, F. Barre-Sinoussi, et al.
Naive T-cell depletion related to infection by x4 human immunodeficiency virus type 1 in poor immunological responders to highly active antiretroviral therapy.
J. Virol.,
October 1, 2006;
80(20):
10229 - 10236.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. van den Dool and R. J. de Boer
The Effects of Age, Thymectomy, and HIV Infection on {alpha} and beta TCR Excision Circles in Naive T Cells
J. Immunol.,
October 1, 2006;
177(7):
4391 - 4401.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
