Blood online
Home About Blood Authors Subscriptions Permission Advertising Public Access contact us
 

 
Advanced
Current Issue
First Edition
Future Articles
Archives
Submit to Blood
Search
American Society of Hematology
Meeting Abstracts
Email Alerts
 Blood, 1 August 2004, Vol. 104, No. 3, pp. 829-831.
Prepublished online as a Blood First Edition Paper on April 15, 2004; DOI 10.1182/blood-2004-02-0477.

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
2004-02-0477v1
104/3/829    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Right arrow Rights and Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Coriu, D.
Right arrow Articles by Solomon, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Coriu, D.
Right arrow Articles by Solomon, A.
Related Collections
Right arrow Neoplasia
Right arrow Brief Reports
Right arrowRelated Article in Blood Online
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

arrow to previous article Previous Article  |  Table of Contents  |  Next Article next article arrow

NEOPLASIA
Brief report

A molecular basis for nonsecretory myeloma

Daniel Coriu, Kristal Weaver, Maria Schell, Manfred Eulitz, Charles L. Murphy, Deborah T. Weiss, and Alan Solomon

From the Human Immunology and Cancer Program, Department of Medicine, University of Tennessee Graduate School of Medicine, Knoxville, TN; GSF Institute of Molecular Immunology, Munich, Germany; and University of Medicine "Carol Davila," Bucharest, Romania.

The biosynthesis of aberrant immunoglobulin polypeptides by monoclonal plasma cells has been implicated in the pathogenesis of nonsecretory myeloma. Our studies of a patient with this disorder indeed have demonstrated the presence of abnormal {kappa} light chains that resulted from a frameshift mutation in nucleotides encoding the constant region of the molecule. As a consequence of a 2-base deletion in codon 187 and loss of the normal stop codon, this portion of the {kappa} chain was composed of 128 amino acids (rather than the expected 106), with a completely anomalous sequence after position 187 that included absence of the cysteines required for intrachain and interchain disulfide bonds. The unusual primary structure of this component was confirmed by mass spectrometric and amino acid sequence analyses of cytoplasmic protein extracts. Our studies provide the first evidence that human nonsecretory myeloma may result from an alteration in the light-chain constant region.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?

Related Article in Blood Online:

Constipated myeloma
P. Leif Bergsagel
Blood 2004 104: 602. [Full Text] [PDF]



This article has been cited by other articles:


Home page
 Br. J. Radiol.Home page
R PRASAD, R R YADAV, A SINGH, S P MATHUR, Y MANGAL, and M SINGH
Non-secretory multiple myeloma presenting with diffuse sclerosis of affected bones interspersed with osteolytic lesions
Br. J. Radiol., February 1, 2009; 82(974): e29 - e31.
[Abstract] [Full Text] [PDF]


click for free articles
home about blood authors subscriptions permissions advertising public access contact us
  Copyright © 2004 by American Society of Hematology         Online ISSN: 1528-0020