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 Blood, 1 August 2004, Vol. 104, No. 3, pp. 829-831.
Prepublished online as a Blood First Edition Paper on April 15, 2004; DOI 10.1182/blood-2004-02-0477.

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NEOPLASIA
Brief report

A molecular basis for nonsecretory myeloma

Daniel Coriu, Kristal Weaver, Maria Schell, Manfred Eulitz, Charles L. Murphy, Deborah T. Weiss, and Alan Solomon

From the Human Immunology and Cancer Program, Department of Medicine, University of Tennessee Graduate School of Medicine, Knoxville, TN; GSF Institute of Molecular Immunology, Munich, Germany; and University of Medicine "Carol Davila," Bucharest, Romania.

The biosynthesis of aberrant immunoglobulin polypeptides by monoclonal plasma cells has been implicated in the pathogenesis of nonsecretory myeloma. Our studies of a patient with this disorder indeed have demonstrated the presence of abnormal {kappa} light chains that resulted from a frameshift mutation in nucleotides encoding the constant region of the molecule. As a consequence of a 2-base deletion in codon 187 and loss of the normal stop codon, this portion of the {kappa} chain was composed of 128 amino acids (rather than the expected 106), with a completely anomalous sequence after position 187 that included absence of the cysteines required for intrachain and interchain disulfide bonds. The unusual primary structure of this component was confirmed by mass spectrometric and amino acid sequence analyses of cytoplasmic protein extracts. Our studies provide the first evidence that human nonsecretory myeloma may result from an alteration in the light-chain constant region.


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Related Article in Blood Online:

Constipated myeloma
P. Leif Bergsagel
Blood 2004 104: 602. [Full Text] [PDF]





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