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 Blood, 15 August 2004, Vol. 104, No. 4, pp. 1198-1200.
Prepublished online as a Blood First Edition Paper on April 27, 2004; DOI 10.1182/blood-2003-11-3884.

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RED CELLS
Brief report

The etiology of severe anemia in a village and a periurban area in Mali

Alassane Dicko, Amy D. Klion, Mahamadou A. Théra, Issaka Sagara, Daniel Yalcouyé, Mohamed B. Niambele, Moussa Sogoba, Guimogo Dolo, Adama Dao, Dapa A. Diallo, Ogobara K. Doumbo, and Louis H. Miller

From the Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, Faculty of Medicine, Pharmacy and Odonto-Stomatology, University of Bamako, Bamako, Mali; and the Laboratory of Parasitic Diseases and the Malaria Vaccine Development Unit, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.

Severe anemia is one of the major complications of malaria in Africa. We studied 2 populations, one in a village and the second in a periurban area in Mali, to understand the preventable factors in the disease. The 2 correlates of disease were parasitemia above 100 000 parasitized red blood cells per microliter (0.1 x 1012/L) and a low baseline hemoglobin level. All cases of moderate to severe anemia occurred in children under 3.2 years of age. Raising the baseline hemoglobin level and lowering peak parasitemia in infants and young children may reduce the incidence of severe anemia resulting from malarial infection. (Blood. 2004;104: 1198-1200)


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