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Blood, 1 September 2004, Vol. 104, No. 5, pp. 1356-1360. Prepublished online as a Blood First Edition Paper on May 18, 2004; DOI 10.1182/blood-2004-01-0229. This Article Full Text Full Text (PDF) All Versions of this Article: 2004-01-0229v1 104/5/1356    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Kosch, A. Articles by Nowak-Göttl, U. Search for Related Content PubMed PubMed Citation Articles by Kosch, A. Articles by Nowak-Göttl, U. Related Collections Hemostasis, Thrombosis, and Vascular Biology Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY Renal venous thrombosis in neonates: prothrombotic risk factors and long-term follow-up Andrea Kosch, Eberhard Kuwertz-Bröking, Christine Heller, Karin Kurnik, Rosemarie Schobess, and Ulrike Nowak-Göttl, for the Childhood Thrombophilia Study Group From the Department of Pediatric Hematology/Oncology and the Department of Pediatric Nephrology, University Children's Hospital Münster, Münster, Germany; the Department of Pediatric Hematology/Oncology, University Children's Hospital Frankfurt am Main, Frankfurt am Main, Germany; the Department of Pediatrics, University Children's Hospital Munich, Munich, Germany; and the Department of Pediatrics, University Children's Hospital Halle, Halle, Germany. The present study was designed to evaluate prothrombotic risk profiles in 59 consecutively recruited white neonates with renal venous thrombosis (RVT). The rates of prothrombotic risk factors (PRs)—for example, the factor V (FV) 1691G> A mutation, the factor II (FII) 20210G> A variant, antithrombin (AT), protein C (PC), protein S (PS), elevated lipoprotein(a) (Lp(a)), total fasting plasma homocysteine (tHcy) levels, and anticardiolipin antibodies (ACAs)—were compared with those of 118 healthy control children. At onset, 32 (54.2%) of the 59 neonates showed underlying clinical conditions; 40 (67.8%) of them and 23 (85.2%) of the 27 infants with idiopathic RVT showed at least one PR. Univariate analysis revealed significantly elevated odds ratios/95% confidence intervals (ORs/95% CIs) for FV and Lp(a). Additionally, PC/AT deficiency and ACAs were found significantly more often in the patient group (P = .04). Multivariate analysis calculated significant ORs/95% CIs only for FV (OR, 9.4; 95% CI, 3.3-26.6) and elevated Lp(a) (OR, 7.6; 95% CI, 2.4-23.8). Of the 59 neonates investigated, 53 revealed renal atrophy, and 13 children additionally suffered from severe arterial hypertension. In conclusion, the present study demonstrates the significance of genetic PR—especially the FV mutation and elevated Lp(a)—for the etiology of neonatal RVT. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: G. Young, M. Albisetti, M. Bonduel, L. Brandao, A. Chan, F. Friedrichs, N. A. Goldenberg, E. Grabowski, C. Heller, J. Journeycake, et al. Impact of Inherited Thrombophilia on Venous Thromboembolism in Children: A Systematic Review and Meta-Analysis of Observational Studies Circulation, September 23, 2008; 118(13): 1373 - 1382. [Abstract] [Full Text] [PDF] K. K. Lau, J. M. Stoffman, S. Williams, P. McCusker, L. Brandao, S. Patel, A. K.C. Chan, and for the Canadian Pediatric Thrombosis and Hemostas Neonatal Renal Vein Thrombosis: Review of the English-Language Literature Between 1992 and 2006 Pediatrics, November 1, 2007; 120(5): e1278 - e1284. [Abstract] [Full Text] [PDF] Y. Messinger, J. W. Sheaffer, J. Mrozek, C. M. Smith, and A. R. Sinaiko Renal Outcome of Neonatal Renal Venous Thrombosis: Review of 28 Patients and Effectiveness of Fibrinolytics and Heparin in 10 Patients Pediatrics, November 1, 2006; 118(5): e1478 - e1484. [Abstract] [Full Text] [PDF] W. Kreuz, M. Stoll, R. Junker, A. Heinecke, R. Schobess, K. Kurnik, R. Kelsch, and U. Nowak-Gottl Familial Elevated Factor VIII in Children With Symptomatic Venous Thrombosis and Post-Thrombotic Syndrome: Results of a Multicenter Study Arterioscler Thromb Vasc Biol, August 1, 2006; 26(8): 1901 - 1906. [Abstract] [Full Text] [PDF] P J D Winyard, T Bharucha, R De Bruyn, M J Dillon, W van't Hoff, R S Trompeter, R Liesner, A Wade, and L Rees Perinatal renal venous thrombosis: presenting renal length predicts outcome Arch. Dis. Child. Fetal Neonatal Ed., July 1, 2006; 91(4): F273 - F278. [Abstract] [Full Text] [PDF]

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