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Blood, 1 September 2004, Vol. 104, No. 5, pp. 1386-1395. Prepublished online as a Blood First Edition Paper on May 20, 2004; DOI 10.1182/blood-2004-03-0850. This Article Full Text Full Text (PDF) All Versions of this Article: 2004-03-0850v1 104/5/1386    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Merck, E. Articles by Bates, E. E. M. Search for Related Content PubMed PubMed Citation Articles by Merck, E. Articles by Bates, E. E. M. Related Collections Immunobiology Phagocytes Signal Transduction Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY OSCAR is an FcR-associated receptor that is expressed by myeloid cells and is involved in antigen presentation and activation of human dendritic cells Estelle Merck, Claude Gaillard, Daniel M. Gorman, Felix Montero-Julian, Isabelle Durand, Sandra M. Zurawski, Christine Menetrier-Caux, Giuseppe Carra, Serge Lebecque, Giorgio Trinchieri, and Elizabeth E. M. Bates From the Schering-Plough Research Institute, Laboratory for Immunological Research, Dardilly, France; DNAX Research Institute, Palo Alto, CA; Immunotech, Beckman Coulter, Marseille, France; Institut National de la Santé et de la Recherche Médicale (INSERM) U453, Centre Léon Bérard, Lyon, France; and the Department of Pathology, Section of Immunology, University of Verona, Italy. We have isolated a novel cell surface molecule, the human homolog of osteoclast-associated receptor (OSCAR). Unlike mouse OSCAR, hOSCAR is widely transcribed in cells of the myeloid lineage. Notably, hOSCAR is expressed on circulating blood monocytes and CD11c+ dendritic cells but not on T and B cells. hOSCAR is continually expressed during differentiation of CD14+ monocytes into dendritic cells and maintained after maturation. hOSCAR associates with the FcR as shown by translocation of FcR to the cell surface in presence of hOSCAR and coimmunoprecipitation from transfected cell lines and ex vivo cells. Engagement of hOSCAR with specific mAb leads to Ca2+ mobilization and cytokine release, indicators of cellular activation. Endocytosis of the receptor in dendritic cells was observed, followed by passage of the internalized material into Lamp-1+ and HLA-DR+ compartments, suggesting a role in antigen uptake and presentation. Dendritic cells were able to stimulate a T-cell clone specific for an epitope of mouse IgG1 after uptake and processing of the hOSCAR-specific antibody, demonstrating the capacity of this receptor to mediate antigen presentation. hOSCAR thus represents a novel class of molecule expressed by dendritic cells involved in the initiation of the immune response. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: K. Kim, J. Lee, J. H. Kim, H. M. Jin, B. Zhou, S. Y. Lee, and N. Kim Protein Inhibitor of Activated STAT 3 Modulates Osteoclastogenesis by Down-Regulation of NFATc1 and Osteoclast-Associated Receptor J. Immunol., May 1, 2007; 178(9): 5588 - 5594. [Abstract] [Full Text] [PDF] K. Kim, J. H. Kim, J. Lee, H. M. Jin, H. Kook, K. K. Kim, S. Y. Lee, and N. Kim MafB negatively regulates RANKL-mediated osteoclast differentiation Blood, April 15, 2007; 109(8): 3253 - 3259. [Abstract] [Full Text] [PDF] J. L. Fallas, W. Yi, N. A. Draghi, H. M. O'Rourke, and L. K. Denzin Expression Patterns of H2-O in Mouse B Cells and Dendritic Cells Correlate with Cell Function J. Immunol., February 1, 2007; 178(3): 1488 - 1497. [Abstract] [Full Text] [PDF] M. Fujimoto, H. Takatsu, and H. Ohno CMRF-35-like molecule-5 constitutes novel paired receptors, with CMRF-35-like molecule-1, to transduce activation signal upon association with FcR{gamma} Int. Immunol., October 1, 2006; 18(10): 1499 - 1508. [Abstract] [Full Text] [PDF] E. Merck, C. Gaillard, M. Scuiller, P. Scapini, M. A. Cassatella, G. Trinchieri, and E. E. M. Bates Ligation of the FcR{gamma} Chain-Associated Human Osteoclast-Associated Receptor Enhances the Proinflammatory Responses of Human Monocytes and Neutrophils. J. Immunol., March 1, 2006; 176(5): 3149 - 3156. [Abstract] [Full Text] [PDF] K. Kim, J. H. Kim, J. Lee, H.-M. Jin, S.-H. Lee, D. E. Fisher, H. Kook, K. K. Kim, Y. Choi, and N. Kim Nuclear Factor of Activated T Cells c1 Induces Osteoclast-associated Receptor Gene Expression during Tumor Necrosis Factor-related Activation-induced Cytokine-mediated Osteoclastogenesis J. Biol. Chem., October 21, 2005; 280(42): 35209 - 35216. [Abstract] [Full Text] [PDF] C. Tenca, A. Merlo, E. Merck, E. E. M. Bates, D. Saverino, R. Simone, D. Zarcone, G. Trinchieri, C. E. Grossi, and E. Ciccone CD85j (Leukocyte Ig-Like Receptor-1/Ig-Like Transcript 2) Inhibits Human Osteoclast-Associated Receptor-Mediated Activation of Human Dendritic Cells J. Immunol., June 1, 2005; 174(11): 6757 - 6763. [Abstract] [Full Text] [PDF] E. Merck, B. de Saint-Vis, M. Scuiller, C. Gaillard, C. Caux, G. Trinchieri, and E. E. M. Bates Fc receptor {gamma}-chain activation via hOSCAR induces survival and maturation of dendritic cells and modulates Toll-like receptor responses Blood, May 1, 2005; 105(9): 3623 - 3632. [Abstract] [Full Text] [PDF]

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