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Blood, 15 September 2004, Vol. 104, No. 6, pp. 1656-1661.
Prepublished online as a Blood First Edition Paper on June 1, 2004; DOI 10.1182/blood-2004-01-0247.
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HEMATOPOIESIS
Roles of MITF for development of mast cells in mice: effects on both precursors and tissue environments
Eiichi Morii,
Keisuke Oboki,
Katsuhiko Ishihara,
Tomoko Jippo,
Toshio Hirano, and
Yukihiko Kitamura
From the Departments of Pathology and Molecular Oncology, Medical School/Graduate School of Frontier Bioscience, Osaka University, Suita, Osaka, Japan; and the Department of Physiology, Senri Kinran University Faculty of Human Life Sciences, Suita, Osaka, Japan.
The mutant tg/tg mice, which do not express mi transcription factor (MITF), lack mast cells in most tissues. Since MITF is expressed in both mast cells and tissues where mast cells develop, there is a possibility that the tg/tg mice may show abnormalities in both mast cell precursors and tissue environments. We examined this possibility by bone marrow and skin transplantation. When bone marrow cells of tg/tg mice were transplanted to W/Wv mice that possess normal tissue environment, mast cells did not develop in all tissues examined. The number of developing mast cells in the skin of W/Wv mice was much lower when grafted to tg/tg recipients than when grafted to normal (+/+) recipients. These results indicated that mast cell precursors of tg/tg mice were defective. When bone marrow cells of +/+ mice were transplanted, the number of developing mast cells was significantly lower in examined tissues of tg/tg recipients than in those of W/Wv recipients, suggesting that the tissue environment for mast cell development was defective in tg/tg mice. MITF appeared essential for the function of both mast cell precursors and tissue environments for their development. (Blood. 2004;104:1656-1661)
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