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Blood, 15 September 2004, Vol. 104, No. 6, pp. 1696-1702.
Prepublished online as a Blood First Edition Paper on June 8, 2004; DOI 10.1182/blood-2004-02-0514.
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HEMATOPOIESIS
Mastermind critically regulates Notch-mediated lymphoid cell fate decisions
Ivan Maillard,
Andrew P. Weng,
Andrea C. Carpenter,
Carlos G. Rodriguez,
Hong Sai,
Lanwei Xu,
David Allman,
Jon C. Aster, and
Warren S. Pear
From the Division of Hematology-Oncology, Abramson Family Cancer Research Institute, Department of Pathology and Laboratory Medicine, Institute for Medicine & Engineering, University of Pennsylvania, Philadelphia; and the Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
During lymphoid development, Notch1 plays a critical role in the T-cell/B-cell lineage decision, while Notch2 is essential for marginal zone B-cell (MZB) development. Notch pathway activation induces translocation of intracellular Notch (ICN) to the nucleus, where it interacts with the transcription factor CSL (CBF1/RBP-Jk, Suppressor of Hairless, Lag-1). In vitro, ICN binds Mastermind-like proteins, which act as potent Notch coactivators. Three MAML family members (MAML1-3) have been identified in mammals, but their importance in vivo is unknown. To investigate the function of MAMLs in hematopoietic development, we introduced a dominant negative (DN) mutant of MAML1, capable of inhibiting Notch1-4, in murine hematopoietic stem cells. DNMAML1 resulted in early inhibition of T-cell development and the appearance of intrathymic B cells, phenotypes consistent with Notch1 inhibition. The T-cell differentiation block was as profound as that produced by enforced expression of the Notch modulator Deltex1. In DNMAML1-transduced spleen cells, a dramatic decrease in MZB cells was present, consistent with Notch2 inhibition. In contrast, Deltex1 did not decrease MZB cell numbers. These results suggest a critical role for MAMLs during Notch-mediated cell fate decisions in vivo and indicate that DNMAML1, but not Deltex1, can be used to interfere with the function of multiple Notch family members. (Blood. 2004;104:1696-1702)
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