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Blood, 15 September 2004, Vol. 104, No. 6, pp. 1801-1807. Prepublished online as a Blood First Edition Paper on June 3, 2004; DOI 10.1182/blood-2004-01-0331. This Article Full Text Full Text (PDF) Supplemental Figures All Versions of this Article: 2004-01-0331v1 104/6/1801    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Angelini, D. F. Articles by Battistini, L. Search for Related Content PubMed PubMed Citation Articles by Angelini, D. F. Articles by Battistini, L. Related Collections Immunobiology Signal Transduction Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY FcRIII discriminates between 2 subsets of V9V2 effector cells with different responses and activation pathways Daniela F. Angelini, Giovanna Borsellino, Mary Poupot, Adamo Diamantini, Rémy Poupot, Giorgio Bernardi, Fabrizio Poccia, Jean-Jacques Fournié, and Luca Battistini From the Neuroimmunology Unit, Santa Lucia Foundation, Scientific Institute (IRCCS), Rome, Italy; the Départment Oncogénèse et Signalisation dans les Cellules Hématopoiétiques, Unité 563 de l'Institut National de la Santé etdela Recherche Médicale, Centre de Physiopathologie de Toulouse Purpan, Toulouse, France; the Department of Neuroscience, University of Rome "Tor Vergata," and the Laboratory of Immunopathology, Padiglione Del Vecchio, National Institute for Infectious Diseases, Rome, Italy. Upon recognition of nonpeptidic phosphoantigens, human V2 T lymphocytes enter a lineage differentiation pattern that determines the generation of memory cells with a range of effector functions. Here, we show that within the effector memory V2 population, 2 distinct and complementary subsets with regard to phenotype, mode of activation, and type of responses can be identified: V2 TEMh cells, which express high levels of chemokine receptors, but low levels of perforin and of natural killer receptors (NKRs) and which produce large amounts of interferon (IFN-) and tumor necrosis factor (TNF-) in response to T-cell receptor (TCR)–specific stimulation by phosphoantigens; and V2TEMRA cells, which constitutively express several NKRs, high amounts of perforin, but low levels of chemokine receptors and of IFN-. These NK-like cells are refractory to phosphoantigen but respond to activation via FcRIII (CD16) and are highly active against tumoral target cells. Thus, circulating V2T lymphocytes comprise 2 functionally diverse subsets of effector memory cells that may be discriminated on the basis of CD16 expression. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: J. Gertner-Dardenne, C. Bonnafous, C. Bezombes, A.-H. Capietto, V. Scaglione, S. Ingoure, D. Cendron, E. Gross, J.-F. Lepage, A. Quillet-Mary, et al. Bromohydrin pyrophosphate enhances antibody-dependent cell-mediated cytotoxicity induced by therapeutic antibodies Blood, May 14, 2009; 113(20): 4875 - 4884. [Abstract] [Full Text] [PDF] N. K. Bjorkstrom, V. D. Gonzalez, K.-J. Malmberg, K. Falconer, A. Alaeus, G. Nowak, C. Jorns, B.-G. Ericzon, O. Weiland, J. K. Sandberg, et al. Elevated Numbers of Fc{gamma}RIIIA+ (CD16+) Effector CD8 T Cells with NK Cell-Like Function in Chronic Hepatitis C Virus Infection J. Immunol., September 15, 2008; 181(6): 4219 - 4228. [Abstract] [Full Text] [PDF] V. Pitard, D. 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