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Blood, 1 October 2004, Vol. 104, No. 7, pp. 2010-2019. Prepublished online as a Blood First Edition Paper on June 22, 2004; DOI 10.1182/blood-2003-12-4219. This Article Full Text Full Text (PDF) Supplemental Figures All Versions of this Article: 2003-12-4219v1 104/7/2010    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Hildbrand, P. Articles by Crisa, L. Search for Related Content PubMed PubMed Citation Articles by Hildbrand, P. Articles by Crisa, L. Related Collections Hematopoiesis and Stem Cells Hemostasis, Thrombosis, and Vascular Biology Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  HEMATOPOIESIS The role of angiopoietins in the development of endothelial cells from cord blood CD34+ progenitors Patrick Hildbrand, Vincenzo Cirulli, Robyn C. Prinsen, Kent A. Smith, Bruce E. Torbett, Daniel R. Salomon, and Laura Crisa From the Department of Molecular and Experimental Medicine and Department of Immunology, The Scripps Research Institute (TSRI), and Department of Pediatrics, University of California San Diego, La Jolla, CA. Circulating endothelial progenitors contribute to neovascularization at sites of injury and tumorigenesis in postnatal life. Yet, the molecular mechanisms initiating the endothelial developmental program of these precursors remain elusive. Here we provide evidence that endothelial development from progenitors circulating in human cord blood requires angiopoietins, a set of growth factors also involved in vascular branching during embryogenesis. We show that cord blood cells with the potential for endothelial development reside in a CD34+CD11b+ subset capable of autonomously producing and binding angiopoietins. Functionally, endogenous angiopoietin-1 regulates initial endothelial cell commitment, whereas angiopoietin-2 enhances expansion of the endothelial cell progeny. These findings suggest a role for angiopoietins as regulators of endothelial development from circulating progenitors and imply a function of angiopoietins at distinct developmental steps in postnatal angiogenesis. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: F. Tian, P. H. Liang, and L.-Y. 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