|
|
Blood, 1 October 2004, Vol. 104, No. 7, pp. 2155-2162.
Prepublished online as a Blood First Edition Paper on June 15, 2004; DOI 10.1182/blood-2004-02-0557.
 Previous Article | Table of Contents | Next Article 
NEOPLASIA
Polymorphisms and haplotypes in folate-metabolizing genes and risk of non-Hodgkin lymphoma
Christine F. Skibola,
Matthew S. Forrest,
Fabio Coppedé,
Luz Agana,
Alan Hubbard,
Martyn T. Smith,
Paige M. Bracci, and
Elizabeth A. Holly
From the School of Public Health, University of California, Berkeley; and Department of Epidemiology and Biostatistics, University of California, San Francisco.
Folate metabolism plays an essential role in DNA synthesis and methylation processes. Deviations in the flux of folate due to genetic variation could result in selective growth and genomic instability and affect susceptibility to various cancers including lymphoma. To test this hypothesis, genetic polymorphisms in the folate metabolic pathway were investigated using DNA from a population-based case-control study of non-Hodgkin lymphoma (NHL) conducted in the San Francisco Bay Area between 1988 and 1995. The polymorphisms examined and haplotypes generated included thymidylate synthase (TYMS 28-bp triple repeat [3R]  double repeat [2R], 1494del6, IVS6 -68C>T, 1122A>G, and 1053C>T); 5,10-methylenetetrahydrofolate reductase (MTHFR 677C>T and 1298A>C); serine hydroxymethyltransferase (SHMT1 C1420T); reduced folate carrier (RFC G80A); and methionine synthase (MTR A2756G), making the present study the largest and most comprehensive to date to evaluate associations between genetic polymorphisms in folatemetabolizing genes and NHL risk. The TYMS 6 base pair (bp)-6bp- (homozygous for 6bp deletion), IVS6 -68C>T, and 1053C>T genotypes (all in complete linkage disequilibrium) were all inversely associated with NHL (TYMS; odds ratio [OR] = 0.57; 0.34-0.94), particularly with diffuse large cell lymphoma (DLCL; OR = 0.29; 0.10-0.82). Further, the MTR 2756AG/GG and the MTHFR 677TT genotypes were associated with increased risk for NHL (OR = 1.3; 0.99-1.7) and follicular lymphoma (FL; OR = 1.8; 0.98-3.1), respectively. We did not observe any significant differences in genotype frequencies of the SHMT1 and RFC polymorphisms between the cases and controls. The associations of DLCL and FL with TYMS 1494del6 and MTHFR 677TT genotypes, respectively, suggest that folate metabolism may play an important role in the pathogenesis of specific subtypes of NHL. (Blood. 2004;104: 2155-2162)
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
Related Letter in Blood Online:
-
Methylenetetrahydrofolate reductase (MTHFR) 677C>T polymorphism and risk of pediatric non-Hodgkin lymphoma in a German study population
- Martin Stanulla, Kathrin Seidemann, Eckart Schnakenberg, Marion Book, Andrea Mehles, Karl Welte, Martin Schrappe, and Alfred Reiter
Blood 2005 105: 906-907.
[Full Text]
[PDF]
This article has been cited by other articles:
|
|
|
|
 
L. S. Kristensen and A. Dobrovic
Direct Genotyping of Single Nucleotide Polymorphisms in Methyl Metabolism Genes Using Probe-Free High-Resolution Melting Analysis
Cancer Epidemiol. Biomarkers Prev.,
May 1, 2008;
17(5):
1240 - 1247.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. E. Kelemen, T. A. Sellers, J. M. Schildkraut, J. M. Cunningham, R. A. Vierkant, V. S. Pankratz, Z. S. Fredericksen, M. K. Gadre, D. N. Rider, M. Liebow, et al.
Genetic Variation in the One-Carbon Transfer Pathway and Ovarian Cancer Risk
Cancer Res.,
April 1, 2008;
68(7):
2498 - 2506.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Koutros, Y. Zhang, Y. Zhu, S. T. Mayne, S. H. Zahm, T. R. Holford, B. P. Leaderer, P. Boyle, and T. Zheng
Nutrients Contributing to One-Carbon Metabolism and Risk of Non-Hodgkin Lymphoma Subtypes
Am. J. Epidemiol.,
February 1, 2008;
167(3):
287 - 294.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. F. Skibola, J. D. Curry, and A. Nieters
Genetic susceptibility to lymphoma
Haematologica,
July 1, 2007;
92(7):
960 - 969.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
U. Lim, S. S. Wang, P. Hartge, W. Cozen, L. E. Kelemen, S. Chanock, S. Davis, A. Blair, M. Schenk, N. Rothman, et al.
Gene-nutrient interactions among determinants of folate and one-carbon metabolism on the risk of non-Hodgkin lymphoma: NCI-SEER Case-Control Study
Blood,
April 1, 2007;
109(7):
3050 - 3059.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. F. Skibola
Obesity, Diet and Risk of Non-Hodgkin Lymphoma
Cancer Epidemiol. Biomarkers Prev.,
March 1, 2007;
16(3):
392 - 395.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Pullmann Jr., K. Abdelmohsen, A. Lal, J. L. Martindale, R. D. Ladner, and M. Gorospe
Differential Stability of Thymidylate Synthase 3'-Untranslated Region Polymorphic Variants Regulated by AUF1
J. Biol. Chem.,
August 18, 2006;
281(33):
23456 - 23463.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. Ichikawa, T. Takahashi, K. Suto, Y. Sasaki, and R. Hirayama
Orotate Phosphoribosyltransferase Gene Polymorphism Predicts Toxicity in Patients Treated with Bolus 5-Fluorouracil Regimen.
Clin. Cancer Res.,
July 1, 2006;
12(13):
3928 - 3934.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Niclot, Q. Pruvot, C. Besson, D. Savoy, E. Macintyre, G. Salles, N. Brousse, B. Varet, P. Landais, P. Taupin, et al.
Implication of the folate-methionine metabolism pathways in susceptibility to follicular lymphomas
Blood,
July 1, 2006;
108(1):
278 - 285.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
U. Lim, S. Weinstein, D. Albanes, P. Pietinen, L. Teerenhovi, P. R. Taylor, J. Virtamo, and R. Stolzenberg-Solomon
Dietary factors of one-carbon metabolism in relation to non-hodgkin lymphoma and multiple myeloma in a cohort of male smokers.
Cancer Epidemiol. Biomarkers Prev.,
June 1, 2006;
15(6):
1109 - 1114.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. A. Clarke, D. M. Undurraga, P. J. Harasty, S. L. Glaser, L. M. Morton, and E. A. Holly
Changes in cancer registry coding for lymphoma subtypes: reliability over time and relevance for surveillance and study.
Cancer Epidemiol. Biomarkers Prev.,
April 1, 2006;
15(4):
630 - 638.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. J. Shrubsole, Y.-T. Gao, Q. Cai, X. O. Shu, Q. Dai, F. Jin, and W. Zheng
MTR and MTRR Polymorphisms, Dietary Intake, and Breast Cancer Risk.
Cancer Epidemiol. Biomarkers Prev.,
March 1, 2006;
15(3):
586 - 588.
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. J. Lightfoot, C. F. Skibola, E. V. Willett, D. R. Skibola, J. M. Allan, F. Coppede, P. J. Adamson, G. J. Morgan, E. Roman, and M. T. Smith
Risk of Non-Hodgkin Lymphoma Associated with Polymorphisms in Folate-Metabolizing Genes
Cancer Epidemiol. Biomarkers Prev.,
December 1, 2005;
14(12):
2999 - 3003.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
U. Lim, M. Schenk, L. E. Kelemen, S. Davis, W. Cozen, P. Hartge, M. H. Ward, and R. Stolzenberg-Solomon
Dietary Determinants of One-Carbon Metabolism and the Risk of Non-Hodgkin's Lymphoma: NCI-SEER Case-Control Study, 1998-2000
Am. J. Epidemiol.,
November 15, 2005;
162(10):
953 - 964.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. M. Ulrich, K. Curtin, J. D. Potter, J. Bigler, B. Caan, and M. L. Slattery
Polymorphisms in the Reduced Folate Carrier, Thymidylate Synthase, or Methionine Synthase and Risk of Colon Cancer
Cancer Epidemiol. Biomarkers Prev.,
November 1, 2005;
14(11):
2509 - 2516.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C.-X. Yang, K. Matsuo, H. Ito, M. Shinoda, S. Hatooka, K. Hirose, K. Wakai, T. Saito, T. Suzuki, T. Maeda, et al.
Gene-environment interactions between alcohol drinking and the MTHFR C677T polymorphism impact on esophageal cancer risk: results of a case-control study in Japan
Carcinogenesis,
July 1, 2005;
26(7):
1285 - 1290.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Stanulla, K. Seidemann, E. Schnakenberg, M. Book, A. Mehles, K. Welte, M. Schrappe, and A. Reiter
Methylenetetrahydrofolate reductase (MTHFR) 677C>T polymorphism and risk of pediatric non-Hodgkin lymphoma in a German study population
Blood,
January 15, 2005;
105(2):
906 - 907.
[Full Text]
[PDF]
|
|
|
| |
