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Blood, 1 October 2004, Vol. 104, No. 7, pp. 2194-2200. Prepublished online as a Blood First Edition Paper on June 15, 2004; DOI 10.1182/blood-2003-07-2430. This Article Full Text Full Text (PDF) All Versions of this Article: 2003-07-2430v1 104/7/2194    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Lee, S. J. Articles by Syrjala, K. L. Search for Related Content PubMed PubMed Citation Articles by Lee, S. J. Articles by Syrjala, K. L. Related Collections Transplantation Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  TRANSPLANTATION Physicians' attitudes about quality-of-life issues in hematopoietic stem cell transplantation Stephanie J. Lee, Steven Joffe, Haesook T. Kim, Gerard Socie, Andrew L. Gilman, John R. Wingard, Mary M. Horowitz, David Cella, and Karen L. Syrjala From the Departments of Adult Oncology, Pediatrics, and Biostatistics, Dana-Farber Cancer Institute, Division of Hematology/Oncology, Children's Hospital, Boston, MA; Service de greffe de moelle, Hospital St Louis, AP-HP, Paris, France; Department of Pediatrics, Children's Mercy Hospital, Kansas City, MO; Department of Medicine, University of Florida College of Medicine, Gainesville; International Bone Marrow Transplant Registry, Milwaukee, WI; Department of Psychiatry and Behavioral Science, Northwestern University, Evanston, IL; and Clinical Research Division, Fred Hutchinson Cancer Research Center and University of Washington School of Medicine. Studies investigating quality of life (QOL) after hematopoietic stem cell transplantation demonstrate the spectrum of QOL outcomes awaiting survivors. Nevertheless, how transplantation physicians interpret and apply QOL information to clinical practice is poorly understood. We conducted a cross-sectional survey of transplantation physicians to address these issues and received 180 (24%) responses from physicians in 29 countries. Seventy-two percent reported that their patients are willing to accept poor QOL for a small chance of cure. Only 28% said that QOL considerations "often" or "almost all the time" enter into patients' decisions about transplantation. This contrasted with physicians' reported attention to QOL in their discussions with patients. Although 53% of physicians reported using QOL results to modify practice, 55% would be more likely to use these data if they were more understandable. To ensure generalizability of the results, a validation sample was randomly selected, and these 85 physicians (response rate, 76%) confirmed the findings of the original survey. Given the extensive data regarding posttransplantation QOL, resources should be devoted to exploring how patients and physicians use these data in clinical care and in devising methods to ensure that QOL results are interpretable and relevant to patients and physicians. (Blood. 2004;104:2194-2200) CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: J. Pidala, C. Anasetti, and H. Jim Quality of life after allogeneic hematopoietic cell transplantation Blood, July 2, 2009; 114(1): 7 - 19. [Abstract] [Full Text] [PDF] K. Gondek, P.-P. Sagnier, K. Gilchrist, and J. M. Woolley Current Status of Patient-Reported Outcomes in Industry-Sponsored Oncology Clinical Trials and Product Labels J. Clin. Oncol., November 10, 2007; 25(32): 5087 - 5093. [Abstract] [Full Text] [PDF] E. Grinstein, Y. Du, S. Santourlidis, J. Christ, M. Uhrberg, and P. Wernet Nucleolin Regulates Gene Expression in CD34-positive Hematopoietic Cells J. Biol. Chem., April 27, 2007; 282(17): 12439 - 12449. [Abstract] [Full Text] [PDF] S. K. Parsons, M.-C. Shih, K. N. DuHamel, J. Ostroff, D. K. Mayer, J. Austin, D. R. Martini, S. E. Williams, L. Mee, S. Sexson, et al. Maternal Perspectives on Children's Health-Related Quality of Life During the First Year After Pediatric Hematopoietic Stem Cell Transplant J. Pediatr. Psychol., November 1, 2006; 31(10): 1100 - 1115. [Abstract] [Full Text] [PDF]

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