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Blood, 15 October 2004, Vol. 104, No. 8, pp. 2217-2223. Prepublished online as a Blood First Edition Paper on July 20, 2004; DOI 10.1182/blood-2004-04-1512. This Article Full Text Full Text (PDF) All Versions of this Article: 2004-04-1512v1 104/8/2217    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Karamatic Crew, V. Articles by Anstee, D. J. Search for Related Content PubMed PubMed Citation Articles by Karamatic Crew, V. Articles by Anstee, D. J. Related Collections Perspectives Red Cells Transfusion Medicine Cell Adhesion and Motility Free Research Articles Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  PLENARY PAPERS CD151, the first member of the tetraspanin (TM4) superfamily detected on erythrocytes, is essential for the correct assembly of human basement membranes in kidney and skin Vanja Karamatic Crew, Nicholas Burton, Alexander Kagan, Carole A. Green, Cyril Levene, Frances Flinter, R. Leo Brady, Geoff Daniels, and David J. Anstee From the Bristol Institute for Transfusion Sciences, National Blood Service, Bristol; the Department of Biochemistry, University of Bristol, Bristol, United Kingdom; the Department of Nephrology and Hypertension, Kaplan Medical Center (affiliated to Hebrew University-Hadassah Medical School), Rehovot, Israel; the National Blood Group Reference Laboratory, Magen David Adom, Blood Services Center, Ramat Gan, Israel; and the Evelina Children's Hospital, Guy's and St Thomas' NHS Trust, London, United Kingdom. Tetraspanins are thought to facilitate the formation of multiprotein complexes at cell surfaces, but evidence illuminating the biologic importance of this role is sparse. Tetraspanin CD151 forms very stable laminin-binding complexes with integrins 31 and 61 in kidney and 31 and 64 in skin. It is encoded by a gene at the same position on chromosome 11p15.5 as the MER2 blood group gene. We show that CD151 expresses the MER2 blood group antigen and is located on erythrocytes. We examined CD151 in 3 MER2-negative patients (2 are sibs) of Indian Jewish origin with end-stage kidney disease. In addition to hereditary nephritis the sibs have sensorineural deafness, pretibial epidermolysis bullosa, and -thalassemia minor. The 3 patients are homozygous for a single nucleotide insertion (G383) in exon 5 of CD151, causing a frameshift and premature stop signal at codon 140. The resultant truncated protein would lack its integrin-binding domain. We conclude that CD151 is essential for the proper assembly of the glomerular and tubular basement membrane in kidney, has functional significance in the skin, is probably a component of the inner ear, and could play a role in erythropoiesis. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Tetraspanin: red blood cells and beyond Marion E. Reid Blood 2004 104: 2211-2212. [Full Text] [PDF] This article has been cited by other articles: J. L. Johnson, N. 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Hemler Deletion of tetraspanin Cd151 results in decreased pathologic angiogenesis in vivo and in vitro Blood, February 15, 2007; 109(4): 1524 - 1532. [Abstract] [Full Text] [PDF] N. Sachs, M. Kreft, M. A. van den Bergh Weerman, A. J. Beynon, T. A. Peters, J. J. Weening, and A. Sonnenberg Kidney failure in mice lacking the tetraspanin CD151 J. Cell Biol., October 9, 2006; 175(1): 33 - 39. [Abstract] [Full Text] [PDF] N. E. Winterwood, A. Varzavand, M. N. Meland, L. K. Ashman, and C. S. Stipp A Critical Role for Tetraspanin CD151 in {alpha}3beta1 and {alpha}6beta4 Integrin-dependent Tumor Cell Functions on Laminin-5 Mol. Biol. Cell, June 1, 2006; 17(6): 2707 - 2721. [Abstract] [Full Text] [PDF] F. Le Naour, M. Andre, C. Greco, M. Billard, B. Sordat, J.-F. Emile, F. Lanza, C. Boucheix, and E. Rubinstein Profiling of the Tetraspanin Web of Human Colon Cancer Cells Mol. Cell. Proteomics, May 1, 2006; 5(5): 845 - 857. [Abstract] [Full Text] [PDF] K. Wilhelmsen, S. H.M. Litjens, and A. Sonnenberg Multiple Functions of the Integrin {alpha}6{beta}4 in Epidermal Homeostasis and Tumorigenesis Mol. Cell. Biol., April 15, 2006; 26(8): 2877 - 2886. [Full Text] [PDF] A. Ziyyat, E. Rubinstein, F. Monier-Gavelle, V. Barraud, O. Kulski, M. Prenant, C. Boucheix, M. Bomsel, and J.-P. Wolf CD9 controls the formation of clusters that contain tetraspanins and the integrin {alpha}6{beta}1, which are involved in human and mouse gamete fusion J. Cell Sci., February 1, 2006; 119(3): 416 - 424. [Abstract] [Full Text] [PDF] R. Nishiuchi, N. Sanzen, S. Nada, Y. Sumida, Y. Wada, M. Okada, J. Takagi, H. Hasegawa, and K. Sekiguchi Potentiation of the ligand-binding activity of integrin {alpha}3{beta}1 via association with tetraspanin CD151 PNAS, February 8, 2005; 102(6): 1939 - 1944. [Abstract] [Full Text] [PDF]

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