SEARCH:   Advanced

Blood, 15 October 2004, Vol. 104, No. 8, pp. 2432-2440. Prepublished online as a Blood First Edition Paper on July 20, 2004; DOI 10.1182/blood-2004-02-0646. This Article Full Text Full Text (PDF) Supplemental Figure All Versions of this Article: 2004-02-0646v1 104/8/2432    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Leen, A. M. Articles by Rooney, C. M. Search for Related Content PubMed PubMed Citation Articles by Leen, A. M. Articles by Rooney, C. M. Related Collections Immunobiology Gene Therapy Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY Conserved CTL epitopes on the adenovirus hexon protein expand subgroup cross-reactive and subgroup-specific CD8+ T cells Ann M. Leen, Uluhan Sili, Elio F. Vanin, Alan M. Jewell, Weidong Xie, Dario Vignali, Pedro A. Piedra, Malcolm K. Brenner, and Cliona M. Rooney From the Center for Cell and Gene Therapy, the Department of Pediatrics, the Department of Medicine, and the Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX; the Methodist Hospital and Texas Children's Hospital, Houston, TX; and the Department of Immunology, St Jude Children's Hospital, Memphis, TN. Adenoviruses often cause lethal infections in immunocompromised individuals. Adoptive transfer of immune T cells offers a therapeutic option, but this strategy has been hindered by the paucity of information on molecular targets of cellular immunity and by the immunologic heterogeneity of the 51 human adenoviruses, which are grouped from A to F on the basis of genome size, composition, homology, and organization. Clonal analysis of the adenovirus-specific cytotoxic T lymphocyte (CTL) responses of seropositive individuals identified 5 novel CD8+ T-cell epitopes, all located in conserved regions of the capsid protein hexon. Reactive T cells were cross-reactive between 2 to 4 groups, while no T cells specific for a single subgroup were detected. Thus, by exploiting these peptide targets, it is possible to prepare a T-cell population capable of reacting with most adenoviruses that cause disease in immunocompromised patients. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: W. C. Russell Adenoviruses: update on structure and function J. Gen. Virol., January 1, 2009; 90(1): 1 - 20. [Abstract] [Full Text] [PDF] A. Joshi, J. Tang, M. Kuzma, J. Wagner, B. Mookerjee, J. Filicko, M. Carabasi, N. Flomenberg, and P. Flomenberg Adenovirus DNA polymerase is recognized by human CD8+ T cells J. Gen. Virol., January 1, 2009; 90(1): 84 - 94. [Abstract] [Full Text] [PDF] R. Kushwah, H. Cao, and J. Hu Characterization of Pulmonary T Cell Response to Helper-Dependent Adenoviral Vectors following Intranasal Delivery J. Immunol., March 15, 2008; 180(6): 4098 - 4108. [Abstract] [Full Text] [PDF] A. M. Leen, A. Christin, M. Khalil, H. Weiss, A. P. Gee, M. K. Brenner, H. E. Heslop, C. M. Rooney, and C. M. Bollard Identification of Hexon-Specific CD4 and CD8 T-Cell Epitopes for Vaccine and Immunotherapy J. Virol., January 1, 2008; 82(1): 546 - 554. [Abstract] [Full Text] [PDF] D. Onion, L. J. Crompton, D. W. Milligan, P. A. H. Moss, S. P. Lee, and V. Mautner The CD4+ T-cell response to adenovirus is focused against conserved residues within the hexon protein J. Gen. Virol., September 1, 2007; 88(9): 2417 - 2425. [Abstract] [Full Text] [PDF] B. Heemskerk, T. van Vreeswijk, L. A. Veltrop-Duits, C. C. Sombroek, K. Franken, R. M. Verhoosel, P. S. Hiemstra, D. van Leeuwen, M. E. Ressing, R. E. M. Toes, et al. Adenovirus-Specific CD4+ T Cell Clones Recognizing Endogenous Antigen Inhibit Viral Replication In Vitro through Cognate Interaction J. Immunol., December 15, 2006; 177(12): 8851 - 8859. [Abstract] [Full Text] [PDF] K. Ebner, M. Rauch, S. Preuner, and T. Lion Typing of Human Adenoviruses in Specimens from Immunosuppressed Patients by PCR-Fragment Length Analysis and Real-Time Quantitative PCR. J. Clin. Microbiol., August 1, 2006; 44(8): 2808 - 2815. [Abstract] [Full Text] [PDF] K. Ebner, W. Pinsker, and T. Lion Comparative Sequence Analysis of the Hexon Gene in the Entire Spectrum of Human Adenovirus Serotypes: Phylogenetic, Taxonomic, and Clinical Implications J. Virol., October 15, 2005; 79(20): 12635 - 12642. [Abstract] [Full Text] [PDF]

	Copyright © 2004 by American Society of Hematology         Online ISSN: 1528-0020