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Blood, 15 October 2004, Vol. 104, No. 8, pp. 2441-2443. Prepublished online as a Blood First Edition Paper on June 29, 2004; DOI 10.1182/blood-2004-04-1325. This Article Full Text Full Text (PDF) Supplemental Table All Versions of this Article: 2004-04-1325v1 104/8/2441    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Bayry, J. Articles by Kaveri, S. V. Search for Related Content PubMed PubMed Citation Articles by Bayry, J. Articles by Kaveri, S. V. Related Collections Immunobiology Brief Reports Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY Brief report Common variable immunodeficiency is associated with defective functions of dendritic cells Jagadeesh Bayry, Sébastien Lacroix-Desmazes, Michel D. Kazatchkine, Lionel Galicier, Yves Lepelletier, David Webster, Yves Lévy, Martha M. Eibl, Eric Oksenhendler, Olivier Hermine, and Srini V. Kaveri From the Institut National de la Santé et de la Recherche Médicale (INSERM) Unité 430 and Université Pierre et Marie Curie, Institut des Cordeliers, Paris, France; the Department of Clinical Immunopathology, Hôpital Saint Louis, Paris, France; the Department of Hematology and Centre National de la Recherche Scientifique (CNRS) Unité Mixte de Recherche 8603, Hôpital Necker, Paris, France; the Department of Immunology, Royal Free Medical School, London, United Kingdom; Service d'Immunologie Clinique, Hôpital Henri Mondor, Créteil Cedex, France; and the Immunology Outpatient Clinic, Schwarzspanierstrasse, Vienna, Austria. Common variable immunodeficiency (CVID) is characterized by hypogammaglobulinemia and defects in T-cell functions that could be primary or secondary. We addressed whether CVID is associated with impairment in the dendritic cell (DC) compartment, as DCs play a central role in the development of adaptive immunity. We demonstrate that DCs from CVID patients display severely perturbed differentiation, maturation, and function, and express markedly reduced levels of the costimulatory molecules that are critical for T-cell stimulation. Patients' DCs induced weak proliferation of allogeneic T cells and produced significantly low amounts of interleukin-12 (IL-12) upon CD40 signaling. Multiple defects in the immune system, including malfunctioning of DCs, appear to be prominent features of CVID patients. Impairment in both the innate and adaptive compartments of the immune system may thus cumulatively account for the inability of CVID patients to eradicate pathogens through conventional immune pathways, thus resulting in an increased risk for recurrent bacterial infections. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Dormant or defiant? Dendritic cells in CVID Pia Björck Blood 2004 104: 2213. [Full Text] [PDF] This article has been cited by other articles: A. Smed-Sorensen, M. Moll, T.-Y. Cheng, K. Lore, A.-C. Norlin, L. Perbeck, D. B. Moody, A.-L. Spetz, and J. K. Sandberg IgG regulates the CD1 expression profile and lipid antigen-presenting function in human dendritic cells via Fc{gamma}RIIa Blood, May 15, 2008; 111(10): 5037 - 5046. [Abstract] [Full Text] [PDF] A. Giovannetti, M. Pierdominici, F. Mazzetta, M. Marziali, C. Renzi, A. M. Mileo, M. De Felice, B. Mora, A. Esposito, R. Carello, et al. Unravelling the Complexity of T Cell Abnormalities in Common Variable Immunodeficiency J. Immunol., March 15, 2007; 178(6): 3932 - 3943. [Abstract] [Full Text] [PDF] C. Cunningham-Rundles, L. Radigan, A. K. Knight, L. Zhang, L. Bauer, and A. Nakazawa TLR9 Activation Is Defective in Common Variable Immune Deficiency J. Immunol., February 1, 2006; 176(3): 1978 - 1987. [Abstract] [Full Text] [PDF] J. Bayry, S. Lacroix-Desmazes, M. D. Kazatchkine, O. Hermine, D. F. Tough, and S. V. Kaveri Modulation of Dendritic Cell Maturation and Function by B Lymphocytes J. Immunol., July 1, 2005; 175(1): 15 - 20. [Abstract] [Full Text] [PDF] A. M. Holm, P. Aukrust, J. K. Damas, F. Muller, B. Halvorsen, and S. S. Froland Abnormal interleukin-7 function in common variable immunodeficiency Blood, April 1, 2005; 105(7): 2887 - 2890. [Abstract] [Full Text] [PDF]

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