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Blood, 1 November 2004, Vol. 104, No. 9, pp. 2643-2645. Prepublished online as a Blood First Edition Paper on July 13, 2004; DOI 10.1182/blood-2004-02-0526. This Article Full Text Full Text (PDF) All Versions of this Article: 2004-02-0526v1 104/9/2643    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Wynn, R. F. Articles by Bellantuono, I. Search for Related Content PubMed PubMed Citation Articles by Wynn, R. F. Articles by Bellantuono, I. Related Collections Transplantation Cell Adhesion and Motility Brief Reports Chemokines, Cytokines, and Interleukins Hematopoiesis Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  CHEMOKINES Brief report A small proportion of mesenchymal stem cells strongly expresses functionally active CXCR4 receptor capable of promoting migration to bone marrow Robert F. Wynn, Claire A. Hart, Carla Corradi-Perini, Liam O'Neill, Caroline A. Evans, J. Ed Wraith, Leslie J. Fairbairn, and Ilaria Bellantuono From the Stem Cell Research Group and Willink Biochemical Genetics Unit, Royal Manchester Children's Hospital, Manchester, United Kingdom; and Cancer Research UK Genito-Urinary Group and Cancer Research UK Gene Therapy Group, Paterson Institute for Cancer Research, Manchester, United Kingdom; and Leukemia Research Fund (LRF) Proteomics Facility, Department of Biomolecular Sciences, UMIST, Manchester, United Kingdom. Homing of bone marrow stromal cells (MSCs) to bone and bone marrow after transplantation, important for the correction of conditions such as metabolic storage disorders, can occur but with poor efficiency. Substantial improvements in engraftment will be required in order to derive a clinical benefit from MSC transplantation. Chemokines are the most important factors controlling cellular migration. Stromal-derived factor-1 (SDF-1) has been shown to be critical in promoting the migration of cells to the bone marrow, via its specific receptor CXCR4. The aim of our study was to investigate CXCR4 expression on MSCs and its role in mediating migration to bone marrow. We show that CXCR4, although present at the surface of a small subset of MSCs, is important for mediating specific migration of these cells to bone marrow. (Blood. 2004; 104:2643-2645) CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: I. A. 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Turner, J. Ratajczak, M. Z. Ratajczak, and A. Janowska-Wieczorek Migration of Bone Marrow and Cord Blood Mesenchymal Stem Cells In Vitro Is Regulated by Stromal-Derived Factor-1-CXCR4 and Hepatocyte Growth Factor-c-met Axes and Involves Matrix Metalloproteinases Stem Cells, May 1, 2006; 24(5): 1254 - 1264. [Abstract] [Full Text] [PDF] M. Honczarenko, Y. Le, M. Swierkowski, I. Ghiran, A. M. Glodek, and L. E. Silberstein Human Bone Marrow Stromal Cells Express a Distinct Set of Biologically Functional Chemokine Receptors Stem Cells, April 1, 2006; 24(4): 1030 - 1041. [Abstract] [Full Text] [PDF] V. Sordi, M. L. Malosio, F. Marchesi, A. Mercalli, R. Melzi, T. Giordano, N. Belmonte, G. Ferrari, B. E. Leone, F. Bertuzzi, et al. Bone marrow mesenchymal stem cells express a restricted set of functionally active chemokine receptors capable of promoting migration to pancreatic islets Blood, July 15, 2005; 106(2): 419 - 427. [Abstract] [Full Text] [PDF] A. Kortesidis, A. Zannettino, S. 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