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Blood, 1 November 2004, Vol. 104, No. 9, pp. 2752-2760. Prepublished online as a Blood First Edition Paper on June 29, 2004; DOI 10.1182/blood-2004-04-1396. This Article Full Text Full Text (PDF) All Versions of this Article: 2004-04-1396v1 104/9/2752    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Ingram, D. A. Articles by Yoder, M. C. Search for Related Content PubMed PubMed Citation Articles by Ingram, D. A. Articles by Yoder, M. C. Related Collections Hematopoiesis and Stem Cells Hemostasis, Thrombosis, and Vascular Biology Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY Identification of a novel hierarchy of endothelial progenitor cells using human peripheral and umbilical cord blood David A. Ingram, Laura E. Mead, Hiromi Tanaka, Virginia Meade, Amy Fenoglio, Kelly Mortell, Karen Pollok, Michael J. Ferkowicz, David Gilley, and Mervin C. Yoder From the Department of Pediatrics, Herman B. Wells Center for Pediatric Research, the Department of Biochemistry and Molecular Biology, and the Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis. Emerging evidence to support the use of endothelial progenitor cells (EPCs) for angiogenic therapies or as biomarkers to assess cardiovascular disease risk and progression is compelling. However, there is no uniform definition of an EPC, which makes interpretation of these studies difficult. Although hallmarks of stem and progenitor cells are their ability to proliferate and to give rise to functional progeny, EPCs are primarily defined by the expression of cell-surface antigens. Here, using adult peripheral and umbilical cord blood, we describe an approach that identifies a novel hierarchy of EPCs based on their clonogenic and proliferative potential, analogous to the hematopoietic cell system. In fact, some EPCs form replatable colonies when deposited at the single-cell level. Using this approach, we also identify a previously unrecognized population of EPCs in cord blood that can achieve at least 100 population doublings, replate into at least secondary and tertiary colonies, and retain high levels of telomerase activity. Thus, these studies describe a clonogenic method to define a hierarchy of EPCs based on their proliferative potential, and they identify a unique population of high proliferative potential-endothelial colony-forming cells (HPP-ECFCs) in human umbilical cord blood. (Blood. 2004;104:2752-2760) CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Endothelial progenitor cells: reporting for duty Monica Bessler Blood 2004 104: 2616-2617. [Full Text] [PDF] This article has been cited by other articles: S. Apostolakis, G. Y.H. Lip, and E. Shantsila Monocytes in heart failure: relationship to a deteriorating immune overreaction or a desperate attempt for tissue repair? Cardiovasc Res, October 28, 2009; (2009) cvp327v2. [Abstract] [Full Text] [PDF] M. Toshner, R. Voswinckel, M. Southwood, R. Al-Lamki, L. S. G. Howard, D. Marchesan, J. Yang, J. Suntharalingam, E. Soon, A. Exley, et al. 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