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Blood, 1 January 2005, Vol. 105, No. 1, pp. 13-21. Prepublished online as a Blood First Edition Paper on September 7, 2004; DOI 10.1182/blood-2004-04-1596. This Article Full Text Full Text (PDF) All Versions of this Article: 2004-04-1596v1 105/1/13    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Riley, J. L. Articles by June, C. H. Search for Related Content PubMed PubMed Citation Articles by Riley, J. L. Articles by June, C. H. Related Collections Immunobiology Apoptosis Review Articles Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  REVIEW ARTICLES The CD28 family: a T-cell rheostat for therapeutic control of T-cell activation James L. Riley, and Carl H. June From the Abramson Family Cancer Research Institute and the Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA. The CD28 family of receptors (CD28, cytotoxic T-lymphocyte–associated antigen 4 [CTLA-4], inducible costimulator [ICOS], program death-1 [PD-1], and B- and T-lymphocyte attenuator [BTLA]) plays a critical role in controlling the adaptive arm of the immune response. While considerable information is available regarding CD28 and CTLA-4, the function of the more recently discovered members of the CD28 family is less well understood. This review will highlight recent findings regarding the CD28 family with special emphasis on effects the CD28 family has on immunopathology, the discovery of costimulatory antibodies with superagonist function, and the status of clinical trials using various strategies to augment or block T-cell costimulation. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: K. R. Jerome Viral Modulation of T-Cell Receptor Signaling J. Virol., May 1, 2008; 82(9): 4194 - 4204. [Full Text] [PDF] C. Tsatsanis, K. Vaporidi, V. Zacharioudaki, A. Androulidaki, Y. Sykulev, A. N. Margioris, and P. N. Tsichlis Tpl2 and ERK transduce antiproliferative T cell receptor signals and inhibit transformation of chronically stimulated T cells PNAS, February 26, 2008; 105(8): 2987 - 2992. [Abstract] [Full Text] [PDF] M Busse, T Traeger, C Potschke, A Billing, A Dummer, E Friebe, C Kiank, U Grunwald, R S Jack, C Schutt, et al. 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