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Blood, 15 May 2005, Vol. 105, No. 10, pp. 3768-3785.
Prepublished online as a Blood First Edition Paper on February 3, 2005; DOI 10.1182/blood-2004-09-3502.


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REVIEW ARTICLES

WHO-EORTC classification for cutaneous lymphomas

Rein Willemze, Elaine S. Jaffe, Günter Burg, Lorenzo Cerroni, Emilio Berti, Steven H. Swerdlow, Elisabeth Ralfkiaer, Sergio Chimenti, José L. Diaz-Perez, Lyn M. Duncan, Florent Grange, Nancy Lee Harris, Werner Kempf, Helmut Kerl, Michael Kurrer, Robert Knobler, Nicola Pimpinelli, Christian Sander, Marco Santucci, Wolfram Sterry, Maarten H. Vermeer, Janine Wechsler, Sean Whittaker, and Chris J. L. M. Meijer

From the Department of Dermatology, Leiden University, Medical Center, the Netherlands; Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD; Department of Dermatology, University Hospital Zürich, Switzerland; Department of Dermatology, University of Graz, Austria; Department of Dermatology, University of Milan-Biococca and Ospedale Magiore, Milan, Italy; Department of Pathology, Division of Hematopathology, University of Pittsburgh School of Medicine, PA; Department of Pathology, University of Copenhagen, Denmark; Department of Dermatology, University of Rome, Italy; Department of Dermatology, Cruces Hospital, Bilbao, Spain; Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA; Department of Dermatology, Hôpital Pasteur, Colmar, France; Department of Pathology, University Hospital Zürich, Switzerland; Department of Dermatology, University of Vienna, Austria; Department of Dermatological Sciences, University of Florence, Italy; Department of Dermatology, Allgemeines Krankenhaus St Georg, Hamburg, Germany; Department of Human Pathology and Oncology, University of Florence, Italy; Department of Dermatology, Charité, Humboldt University, Berlin, Germany; Department of Pathology, Hôpital Henri Mondor, Creteil, France; Skin Tumour Unit, St John's Institute of Dermatology, St Thomas' Hospital, London, England; and Department of Pathology, Vrije Universiteit Medical Center, Amsterdam, the Netherlands.

Primary cutaneous lymphomas are currently classified by the European Organization for Research and Treatment of Cancer (EORTC) classification or the World Health Organization (WHO) classification, but both systems have shortcomings. In particular, differences in the classification of cutaneous T-cell lymphomas other than mycosis fungoides, Sézary syndrome, and the group of primary cutaneous CD30+ lymphoproliferative disorders and the classification and terminology of different types of cutaneous B-cell lymphomas have resulted in considerable debate and confusion. During recent consensus meetings representatives of both systems reached agreement on a new classification, which is now called the WHO-EORTC classification. In this paper we describe the characteristic features of the different primary cutaneous lymphomas and other hematologic neoplasms frequently presenting in the skin, and discuss differences with the previous classification schemes. In addition, the relative frequency and survival data of 1905 patients with primary cutaneous lymphomas derived from Dutch and Austrian registries for primary cutaneous lymphomas are presented to illustrate the clinical significance of this new classification.


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JCOHome page
N. J. Senff, J. J. Hoefnagel, P. M. Jansen, M. H. Vermeer, J. van Baarlen, W. A. Blokx, M. R. Canninga-van Dijk, M.-L. Geerts, K. M. Hebeda, P. M. Kluin, et al.
Reclassification of 300 Primary Cutaneous B-Cell Lymphomas According to the New WHO-EORTC Classification for Cutaneous Lymphomas: Comparison With Previous Classifications and Identification of Prognostic Markers
J. Clin. Oncol., April 20, 2007; 25(12): 1581 - 1587.
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BloodHome page
A. Woetmann, P. Lovato, K. W. Eriksen, T. Krejsgaard, T. Labuda, Q. Zhang, A.-M. Mathiesen, C. Geisler, A. Svejgaard, M. A. Wasik, et al.
Nonmalignant T cells stimulate growth of T-cell lymphoma cells in the presence of bacterial toxins
Blood, April 15, 2007; 109(8): 3325 - 3332.
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J. Clin. Pathol.Home page
C. M Bacon, M.-Q. Du, and A. Dogan
Mucosa-associated lymphoid tissue (MALT) lymphoma: a practical guide for pathologists
J. Clin. Pathol., April 1, 2007; 60(4): 361 - 372.
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Arch DermatolHome page
A Nodule on a Boy's Back--Diagnosis
Arch Dermatol, March 1, 2007; 143(3): 417 - 422.
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Arch DermatolHome page
Persistent Violaceous Papules on the Ears--Diagnosis
Arch Dermatol, March 1, 2007; 143(3): 417 - 422.
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BloodHome page
R. Dijkman, R. van Doorn, K. Szuhai, R. Willemze, M. H. Vermeer, and C. P. Tensen
Gene-expression profiling and array-based CGH classify CD4+CD56+ hematodermic neoplasm and cutaneous myelomonocytic leukemia as distinct disease entities
Blood, February 15, 2007; 109(4): 1720 - 1727.
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ASH Education BookHome page
G. A. Salles
Clinical Features, Prognosis and Treatment of Follicular Lymphoma
Hematology, January 1, 2007; 2007(1): 216 - 225.
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BloodHome page
M. Duvic, R. Talpur, X. Ni, C. Zhang, P. Hazarika, C. Kelly, J. H. Chiao, J. F. Reilly, J. L. Ricker, V. M. Richon, et al.
Phase 2 trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) for refractory cutaneous T-cell lymphoma (CTCL)
Blood, January 1, 2007; 109(1): 31 - 39.
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Arch DermatolHome page
R. Bergman, Z. Khamaysi, D. Sahar, and Y. Ben-Arieh
Cutaneous Lymphoid Hyperplasia Presenting as a Solitary Facial Nodule: Clinical, Histopathological, Immunophenotypical, and Molecular Studies
Arch Dermatol, December 1, 2006; 142(12): 1561 - 1566.
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Ann OncolHome page
D Errante, D Bernardi, A Bianco, S De Nardi, and L Salvagno
Rituximab-related urticarial reaction in a patient treated for primary cutaneous B-cell lymphoma
Ann. Onc., November 1, 2006; 17(11): 1720 - 1721.
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The OncologistHome page
M. Bouzani, T. Karmiris, D. Rontogianni, S. Delimpassi, J. Apostolidis, M. Mpakiri, and E. Nikiforakis
Disseminated Intravascular B-Cell Lymphoma: Clinicopathological Features and Outcome of Three Cases Treated with Anthracycline-Based Immunochemotherapy
Oncologist, September 1, 2006; 11(8): 923 - 928.
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The OncologistHome page
R. Gruber, N. T. Sepp, P. O. Fritsch, and M. Schmuth
Prognosis of Lymphomatoid Papulosis
Oncologist, September 1, 2006; 11(8): 955 - 957.
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The OncologistHome page
J. R. Brown
In Reply
Oncologist, September 1, 2006; 11(8): 957 - 957.
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JCOHome page
P. L. Zinzani, P. Quaglino, N. Pimpinelli, E. Berti, G. Baliva, S. Rupoli, M. Martelli, M. Alaibac, G. Borroni, S. Chimenti, et al.
In Reply
J. Clin. Oncol., August 20, 2006; 24(24): 4041a - 4042.
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Clin. Cancer Res.Home page
S. Hahtola, S. Tuomela, L. Elo, T. Hakkinen, L. Karenko, B. Nedoszytko, H. Heikkila, U. Saarialho-Kere, J. Roszkiewicz, T. Aittokallio, et al.
Th1 Response and Cytotoxicity Genes Are Down-Regulated in Cutaneous T-Cell Lymphoma.
Clin. Cancer Res., August 15, 2006; 12(16): 4812 - 4821.
[Abstract] [Full Text] [PDF]


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J. Clin. Pathol.Home page
L Cerroni
Lymphoproliferative lesions of the skin.
J. Clin. Pathol., August 1, 2006; 59(8): 813 - 826.
[Abstract] [Full Text] [PDF]


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The OncologistHome page
E. Jacobsen
Anaplastic Large-Cell Lymphoma, T-/Null-Cell Type
Oncologist, July 1, 2006; 11(7): 831 - 840.
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Journal Watch DermatologyHome page
Reviews of Note
Journal Watch Dermatology, June 27, 2006; 2006(627): 9 - 9.
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BloodHome page
R. Dijkman, C. P. Tensen, M. Buettner, G. Niedobitek, R. Willemze, and M. H. Vermeer
Primary cutaneous follicle center lymphoma and primary cutaneous large B-cell lymphoma, leg type, are both targeted by aberrant somatic hypermutation but demonstrate differential expression of AID
Blood, June 15, 2006; 107(12): 4926 - 4929.
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Clin. Cancer Res.Home page
Y. Fujita, R. Abe, M. Sasaki, A. Honda, M. Furuichi, Y. Asano, O. Norisugi, T. Shimizu, and H. Shimizu
Presence of Circulating CCR10+ T cells and Elevated Serum CTACK/CCL27 in the Early Stage of Mycosis Fungoides.
Clin. Cancer Res., May 1, 2006; 12(9): 2670 - 2675.
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INT J SURG PATHOLHome page
E. Zambrano, O. Mejia-Mejia, C. Bifulco, J. Shin, and M. Reyes-Mugica
Extranodal Marginal Zone B-Cell Lymphoma/Maltoma of the Lip in a Child: Case Report and Review of Cutaneous Lymphoid Proliferations in Childhood
International Journal of Surgical Pathology, April 1, 2006; 14(2): 163 - 169.
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JCOHome page
P. L. Zinzani, P. Quaglino, N. Pimpinelli, E. Berti, G. Baliva, S. Rupoli, M. Martelli, M. Alaibac, G. Borroni, S. Chimenti, et al.
Prognostic Factors in Primary Cutaneous B-Cell Lymphoma: The Italian Study Group for Cutaneous Lymphomas
J. Clin. Oncol., March 20, 2006; 24(9): 1376 - 1382.
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BloodHome page
M. A. Rizvi, A. M. Evens, M. S. Tallman, B. P. Nelson, and S. T. Rosen
T-cell non-Hodgkin lymphoma
Blood, February 15, 2006; 107(4): 1255 - 1264.
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BloodHome page
M. G. Narducci, E. Scala, A. Bresin, E. Caprini, M. C. Picchio, D. Remotti, G. Ragone, F. Nasorri, M. Frontani, D. Arcelli, et al.
Skin homing of Sezary cells involves SDF-1-CXCR4 signaling and down-regulation of CD26/dipeptidylpeptidase IV
Blood, February 1, 2006; 107(3): 1108 - 1115.
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Clin. Cancer Res.Home page
K.-i. Yamanaka, R. Clark, R. Dowgiert, D. Hurwitz, M. Shibata, B. E. Rich, K. Hirahara, D. A. Jones, S. Eapen, H. Mizutani, et al.
Expression of Interleukin-18 and Caspase-1 in Cutaneous T-Cell Lymphoma
Clin. Cancer Res., January 15, 2006; 12(2): 376 - 382.
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JCOHome page
R. Dijkman, C. P. Tensen, E. S. Jordanova, J. Knijnenburg, J. J. Hoefnagel, A. A. Mulder, C. Rosenberg, A. K. Raap, R. Willemze, K. Szuhai, et al.
Array-Based Comparative Genomic Hybridization Analysis Reveals Recurrent Chromosomal Alterations and Prognostic Parameters in Primary Cutaneous Large B-Cell Lymphoma
J. Clin. Oncol., January 10, 2006; 24(2): 296 - 305.
[Abstract] [Full Text] [PDF]


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ASH Education BookHome page
E. S. Jaffe
Pathobiology of Peripheral T-cell Lymphomas
Hematology, January 1, 2006; 2006(1): 317 - 322.
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ASH Education BookHome page
S. T. Rosen and C. Querfeld
Primary Cutaneous T-Cell Lymphomas
Hematology, January 1, 2006; 2006(1): 323 - 330.
[Abstract] [Full Text] [PDF]


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JCOHome page
G. M. Dores, W. F. Anderson, and S. S. Devesa
Cutaneous Lymphomas Reported to the National Cancer Institute's Surveillance, Epidemiology, and End Results Program: Applying the New WHO-European Organisation for Research and Treatment of Cancer Classification System
J. Clin. Oncol., October 1, 2005; 23(28): 7246 - 7248.
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BloodHome page
K. Kodama, C. Massone, A. Chott, D. Metze, H. Kerl, and L. Cerroni
Primary cutaneous large B-cell lymphomas: clinicopathologic features, classification, and prognostic factors in a large series of patients
Blood, October 1, 2005; 106(7): 2491 - 2497.
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Arch DermatolHome page
J. J. Hoefnagel, M. H. Vermeer, P. M. Jansen, F. Heule, P. C. van Voorst Vader, C. J. G. Sanders, M. J. P. Gerritsen, M. L. Geerts, C. J. L. M. Meijer, E. M. Noordijk, et al.
Primary Cutaneous Marginal Zone B-Cell Lymphoma: Clinical and Therapeutic Features in 50 Cases
Arch Dermatol, September 1, 2005; 141(9): 1139 - 1145.
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Arch DermatolHome page
Fever and Necrotic Nodules on the Extremities--Diagnosis
Arch Dermatol, August 1, 2005; 141(8): 1035 - 1040.
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BloodHome page
E. S. Jaffe
Cutaneous lymphomas: it's location, location, location
Blood, May 1, 2005; 105(9): 3394 - 3395.
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