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 Blood, 15 May 2005, Vol. 105, No. 10, pp. 3786-3792.
Prepublished online as a Blood First Edition Paper on January 27, 2005; DOI 10.1182/blood-2004-10-4125.

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REVIEW IN TRANSLATIONAL HEMATOLOGY

New trends in umbilical cord blood transplantation

Karen K. Ballen

From Massachusetts General Hospital, Boston, MA.

Abstract

Since the first report of a successful umbilical cord blood transplantation in 1988, there has been great interest in the use of cord blood as an alternative stem cell source to treat cancer and genetic diseases. More than 4000 cord blood transplantations have been performed worldwide. In this review, the scientific rationale for this therapy, as well as related preclinical studies, cord blood banking issues, and ethical concerns, will be addressed. Results of studies in both pediatric and adult transplantation will be discussed. Finally, new indications for cord blood use and emerging technologies will be addressed.


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