SEARCH:   Advanced

Blood, 15 May 2005, Vol. 105, No. 10, pp. 3793-3801. Prepublished online as a Blood First Edition Paper on January 27, 2005; DOI 10.1182/blood-2004-11-4349. This Article Full Text Full Text (PDF) All Versions of this Article: 2004-11-4349v1 105/10/3793    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Kortesidis, A. Articles by Gronthos, S. Search for Related Content PubMed PubMed Citation Articles by Kortesidis, A. Articles by Gronthos, S. Related Collections Hematopoiesis and Stem Cells Apoptosis Cell Cycle Chemokines, Cytokines, and Interleukins Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  CHEMOKINES Stromal-derived factor-1 promotes the growth, survival, and development of human bone marrow stromal stem cells Angela Kortesidis, Andrew Zannettino, Sandra Isenmann, Songtao Shi, Tsvee Lapidot, and Stan Gronthos From the Mesenchymal Stem Cell Group, Division of Haematology, Institute of Medical and Veterinary Science/Hanson Institute, Adelaide, South Australia, Australia; Myeloma and Mesenchymal Research Group, Matthew Roberts Foundation Laboratory, Division of Haematology, Institute of Medical and Veterinary Science/Hanson Institute, Adelaide, South Australia, Australia; Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD; and Department of Immunology, The Wiezmann Institute of Science, Rehovot, Israel. The maintenance of bone marrow stromal stem cells (BMSSCs) is tightly controlled by the local microenvironment and by autocrine regulatory factors secreted by BMSSCs. To identify such factors, a cDNA subtraction library was generated from purified BMSSCs, based on their high expression of the STRO-1 antigen. Stromal-derived factor-1 (SDF-1) was one differentially expressed gene highly expressed by purified BMSSCs prior to culture. In vitro, immature preosteogenic cells expressed greater levels of SDF-1 when compared with mature cell types representative of osteoblasts and osteocytes/bone lining cells. Furthermore, SDF-1 expression was rapidly down-regulated when BMSSCs were cultured under osteoinductive conditions. BMSSCs were also shown to express functional cell surface SDF-1 receptors (CXCR4). Transduced BMSSC lines, secreting high SDF-1 levels, displayed an enhanced ability to form ectopic bone in vivo, in comparison with control BMSSC lines. Moreover, high SDF-1–expressing BMSSCs displayed an increased capacity for cellular growth and protection against interleukin-4–induced apoptosis. Similarly, fibroblast colony-forming units (CFU-Fs) also displayed increased growth and resistance to -interferon-2a–induced apoptosis, in synergy with platelet-derived growth factor BB (PDGF-BB) and SDF-1 in vitro. These studies indicate that the chemokine, SDF-1, may play a role in the maintenance, survival, and osteogenic capacity of immature BMSSC populations. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: M. Dominici, V. Rasini, R. Bussolari, X. Chen, T. J. Hofmann, C. Spano, D. Bernabei, E. Veronesi, F. Bertoni, P. Paolucci, et al. Restoration and reversible expansion of the osteoblastic hematopoietic stem cell niche after marrow radioablation Blood, September 10, 2009; 114(11): 2333 - 2343. [Abstract] [Full Text] [PDF] G.T.-J. Huang, S. Gronthos, and S. Shi Mesenchymal Stem Cells Derived from Dental Tissues vs. Those from Other Sources: Their Biology and Role in Regenerative Medicine Journal of Dental Research, September 1, 2009; 88(9): 792 - 806. [Abstract] [Full Text] [PDF] A. Arthur, S. Koblar, S. Shi, and S. Gronthos Eph/ephrinB Mediate Dental Pulp Stem Cell Mobilization and Function Journal of Dental Research, September 1, 2009; 88(9): 829 - 834. [Abstract] [Full Text] [PDF] T. Zhao, D. Zhang, R. W. Millard, M. Ashraf, and Y. Wang Stem cell homing and angiomyogenesis in transplanted hearts are enhanced by combined intramyocardial SDF-1{alpha} delivery and endogenous cytokine signaling Am J Physiol Heart Circ Physiol, April 1, 2009; 296(4): H976 - H986. [Abstract] [Full Text] [PDF] C. Kyriakou, N. Rabin, A. Pizzey, A. Nathwani, and K. Yong Factors that influence short-term homing of human bone marrow-derived mesenchymal stem cells in a xenogeneic animal model Haematologica, October 1, 2008; 93(10): 1457 - 1465. [Abstract] [Full Text] [PDF] H. Shichinohe, S. Kuroda, S. Tsuji, S. Yamaguchi, S. Yano, J.-B. Lee, H. Kobayashi, S. Kikuchi, K. Hida, and Y. Iwasaki Bone Marrow Stromal Cells Promote Neurite Extension in Organotypic Spinal Cord Slice: Significance for Cell Transplantation Therapy Neurorehabil Neural Repair, September 1, 2008; 22(5): 447 - 457. [Abstract] [PDF] A. Saxena, J. E. Fish, M. D. White, S. Yu, J. W.P. Smyth, R. M. Shaw, J. M. DiMaio, and D. Srivastava Stromal Cell-Derived Factor-1{alpha} Is Cardioprotective After Myocardial Infarction Circulation, April 29, 2008; 117(17): 2224 - 2231. [Abstract] [Full Text] [PDF] B. Mazzinghi, E. Ronconi, E. Lazzeri, C. Sagrinati, L. Ballerini, M. L. Angelotti, E. Parente, R. Mancina, G. S. Netti, F. Becherucci, et al. Essential but differential role for CXCR4 and CXCR7 in the therapeutic homingof human renal progenitor cells J. Exp. Med., February 18, 2008; 205(2): 479 - 490. [Abstract] [Full Text] [PDF] E. Jones and D. McGonagle Human bone marrow mesenchymal stem cells in vivo Rheumatology, February 1, 2008; 47(2): 126 - 131. [Abstract] [Full Text] [PDF] M. Zhang, N. Mal, M. Kiedrowski, M. Chacko, A. T. Askari, Z. B. Popovic, O. N. Koc, and M. S. Penn SDF-1 expression by mesenchymal stem cells results in trophic support of cardiac myocytes after myocardial infarction FASEB J, October 1, 2007; 21(12): 3197 - 3207. [Abstract] [Full Text] [PDF] W. Zhu, O. Boachie-Adjei, B. A. Rawlins, B. Frenkel, A. L. Boskey, L. B. Ivashkiv, and C. P. Blobel A Novel Regulatory Role for Stromal-derived Factor-1 Signaling in Bone Morphogenic Protein-2 Osteogenic Differentiation of Mesenchymal C2C12 Cells J. Biol. Chem., June 29, 2007; 282(26): 18676 - 18685. [Abstract] [Full Text] [PDF] A. Wimmer, S. K. Khaldoyanidi, M. Judex, N. Serobyan, R. G. DiScipio, and I. U. Schraufstatter CCL18/PARC stimulates hematopoiesis in long-term bone marrow cultures indirectly through its effect on monocytes Blood, December 1, 2006; 108(12): 3722 - 3729. [Abstract] [Full Text] [PDF] A. L. Moharita, M. Taborga, K. E. Corcoran, M. Bryan, P. S. Patel, and P. Rameshwar SDF-1{alpha} regulation in breast cancer cells contacting bone marrow stroma is critical for normal hematopoiesis Blood, November 15, 2006; 108(10): 3245 - 3252. [Abstract] [Full Text] [PDF] T. Lapidot, A. Dar, and O. Kollet How do stem cells find their way home? Blood, September 15, 2005; 106(6): 1901 - 1910. [Abstract] [Full Text] [PDF]

	Copyright © 2005 by American Society of Hematology         Online ISSN: 1528-0020