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Blood, 15 May 2005, Vol. 105, No. 10, pp. 3817-3823. Prepublished online as a Blood First Edition Paper on February 1, 2005; DOI 10.1182/blood-2004-10-3920. This Article Full Text Full Text (PDF) All Versions of this Article: 2004-10-3920v1 105/10/3817    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Deconinck, E. Articles by Colombat, P. Search for Related Content PubMed PubMed Citation Articles by Deconinck, E. Articles by Colombat, P. Related Collections Neoplasia Transplantation Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS High-dose therapy followed by autologous purged stem-cell transplantation and doxorubicin-based chemotherapy in patients with advanced follicular lymphoma: a randomized multicenter study by GOELAMS Eric Deconinck, Charles Foussard, Noel Milpied, Philippe Bertrand, Patrick Michenet, Pascale Cornillet-LeFebvre, Martine Escoffre-Barbe, Herve Maisonneuve, Vincent Delwail, Remy Gressin, Eric Legouffe, Jean-Pierre Vilque, Bernard Desablens, Jerome Jaubert, Jean-François Ramee, Arash Jenabian, Antoine Thyss, Annick Le Pourhiet-Le Mevel, Philippe Travade, Roselyne Delepine, Philippe Colombat, GOELAMS From the Institut National de la Santé et de la Recherche Médicale U645, Université de Besançon-Equipe d'Accueil 2284-Institut Fédératif de Recherche 133, Etablissement Français du Sang Bourgogne-Franche-Comté, Department of Hematology-University Hospital-Jean Minjoz Hospital, Besançon; Department of Hematology, University Hospital, Angers; Department of Hematology, University Hospital of Nantes, Hotel Dieu, Nantes; Department of Hematology and Biostatistics, University Hospital of Tours, Bretonneau Hospital, Tours; Department of Pathology, Centre Hospitalier, Orléans; Department of Hematology and Cytogenetics, University Hospital, Reims; Department of Hematology, University Hospital, Brest; Department of Hematology, Centre Hospitalier, La Roche-sur-Yon; Department of Hematology, University Hospital of Poitiers, Jean Bernard Hospital, Poitiers; Department of Hematology, University Hospital, Grenoble; Department of Hematology, University Hospital of Montpellier; Department of Hematology, University Hospital, Reims; Department of Hematology, University Hospital, Amiens; Department of Hematology, University Hospital, Saint-Etienne; Department of Hematology, Catherine de Sienne Clinic, Nantes; Department of Hematology, Hôpital Européen Georges Pompidou, Paris; Lacassagne Anticancer Center, Nice; Gauduchot Anticancer Center, Nantes; Department of Hematology, University Hospital, Clermont-Ferrand, France; and Department of Hematology, University Hospital, Tours, France. Doxorubicin-based immunochemotherapy, with interferon, has been shown to improve survival in patients with advanced follicular lymphoma. High-dose chemotherapy with stem-cell support is effective in follicular lymphoma in relapse but remains controversial as a first-line therapy. In a randomized study using a purged autologous stem-cell support, we compared these 2 approaches in patients with advanced follicular lymphoma. Newly diagnosed advanced follicular lymphoma patients (172 patients) were randomly assigned either to an immunochemotherapy regimen (cyclophosphamide, doxorubicin, teniposide, prednisone, and interferon) or to a high-dose therapy followed by purged autologous stem-cell transplantation. Compared with the patients who received chemotherapy and interferon, patients treated with high-dose therapy had a higher response rate (69% vs 81%, P = .045) and a longer median event-free survival (not reached vs 45 months). This did not translate into a better survival rate due to an excess of secondary malignancies after transplantation. The Follicular Lymphoma Prognostic Index identified a subgroup of patients with a significantly higher event-free survival rate after high-dose therapy. Autologous stem-cell transplantation cannot be considered as the standard first-line treatment of follicular lymphoma for patients younger than 60 years old with a high tumor burden. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: F. R. Appelbaum Hematopoietic Cell Transplantation for Non-Hodgkin's Lymphoma: Yesterday, Today, and Tomorrow J. Clin. Oncol., June 20, 2008; 26(18): 2927 - 2929. [Full Text] [PDF] J. P. Plastaras, E. Glatstein, and S. J. Schuster Commentary: Let the Tail Wag the Dog: The Case for Radioimmunotherapy of Low-Grade Follicular Lymphoma Oncologist, June 1, 2008; 13(6): 655 - 656. [Full Text] [PDF] F. Buchegger, O. W. Press, A. B. Delaloye, and N. Ketterer Radiolabeled and Native Antibodies and the Prospect of Cure of Follicular Lymphoma Oncologist, June 1, 2008; 13(6): 657 - 667. [Abstract] [Full Text] [PDF] M. Ladetto, F. De Marco, F. Benedetti, U. Vitolo, C. Patti, A. Rambaldi, A. Pulsoni, M. Musso, A. M. Liberati, A. Olivieri, et al. Prospective, multicenter randomized GITMO/IIL trial comparing intensive (R-HDS) versus conventional (CHOP-R) chemoimmunotherapy in high-risk follicular lymphoma at diagnosis: the superior disease control of R-HDS does not translate into an overall survival advantage Blood, April 15, 2008; 111(8): 4004 - 4013. [Abstract] [Full Text] [PDF] A. Z.S. Rohatiner, L. Nadler, A. J. Davies, J. Apostolidis, D. Neuberg, J. Matthews, J. G. Gribben, P. M. Mauch, T. A. Lister, and A. S. Freedman Myeloablative Therapy With Autologous Bone Marrow Transplantation for Follicular Lymphoma at the Time of Second or Subsequent Remission: Long-Term Follow-Up J. Clin. Oncol., June 20, 2007; 25(18): 2554 - 2559. [Abstract] [Full Text] [PDF] J. G. Gribben How I treat indolent lymphoma Blood, June 1, 2007; 109(11): 4617 - 4626. [Abstract] [Full Text] [PDF] M. Herold, A. Haas, S. Srock, S. Neser, K. H. Al-Ali, A. Neubauer, G. Dolken, R. Naumann, W. Knauf, M. Freund, et al. Rituximab Added to First-Line Mitoxantrone, Chlorambucil, and Prednisolone Chemotherapy Followed by Interferon Maintenance Prolongs Survival in Patients With Advanced Follicular Lymphoma: An East German Study Group Hematology and Oncology Study J. Clin. Oncol., May 20, 2007; 25(15): 1986 - 1992. [Abstract] [Full Text] [PDF] S. Vigouroux, M. Michallet, R. Porcher, M. Attal, L. Ades, M. Bernard, D. Blaise, R. Tabrizi, F. Garban, J.-P. Cassuto, et al. Long-term outcomes after reduced-intensity conditioning allogeneic stem cell transplantation for low-grade lymphoma: a survey by the French Society of Bone Marrow Graft Transplantation and Cellular Therapy (SFGM-TC) Haematologica, May 1, 2007; 92(5): 627 - 634. [Abstract] [Full Text] [PDF] A. K. Gopal, J. G. Rajendran, T. A. Gooley, J. M. Pagel, D. R. Fisher, S. H. Petersdorf, D. G. Maloney, J. F. Eary, F. R. Appelbaum, and O. W. Press High-Dose [131I]Tositumomab (anti-CD20) Radioimmunotherapy and Autologous Hematopoietic Stem-Cell Transplantation for Adults >= 60 Years Old With Relapsed or Refractory B-Cell Lymphoma J. Clin. Oncol., April 10, 2007; 25(11): 1396 - 1402. [Abstract] [Full Text] [PDF] C Nickenig, M Dreyling, E Hoster, W-D Ludwig, B Dorken, M Freund, C Huber, A Ganser, L Trumper, R Forstpointner, et al. Initial chemotherapy with mitoxantrone, chlorambucil, prednisone impairs the collection of stem cells in patients with indolent lymphomas--results of a randomized comparison by the German Low-Grade Lymphoma Study Group Ann. Onc., January 1, 2007; 18(1): 136 - 142. [Abstract] [Full Text] [PDF] K. van Besien Autologous transplantation for follicular lymphoma? Not too soon! Blood, October 15, 2006; 108(8): 2496 - 2497. [Full Text] [PDF] C. Sebban, N. Mounier, N. Brousse, C. Belanger, P. Brice, C. Haioun, H. Tilly, P. Feugier, R. Bouabdallah, C. Doyen, et al. Standard chemotherapy with interferon compared with CHOP followed by high-dose therapy with autologous stem cell transplantation in untreated patients with advanced follicular lymphoma: the GELF-94 randomized study from the Groupe d'Etude des Lymphomes de l'Adulte (GELA) Blood, October 15, 2006; 108(8): 2540 - 2544. [Abstract] [Full Text] [PDF] T. Kober, H. Hulsewede, J. Bohlius, and A. Engert Fourth biannual report of the Cochrane Haematological Malignancies Group. J Natl Cancer Inst, April 19, 2006; 98(8): E1 - E1. [Full Text] J. R. Brown and A. S. Freedman In Reply: J. Clin. Oncol., November 1, 2005; 23(31): 8121 - 8122. [Full Text] [PDF] G. Lenz, M. Dreyling, M. Unterhalt, and W. Hiddemann In Reply: J. Clin. Oncol., September 1, 2005; 23(25): 6264 - 6266. [Full Text] [PDF]

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