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Blood, 15 May 2005, Vol. 105, No. 10, pp. 4143-4145. Prepublished online as a Blood First Edition Paper on January 21, 2005; DOI 10.1182/blood-2004-11-4193. This Article Full Text Full Text (PDF) All Versions of this Article: 2004-11-4193v1 105/10/4143    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Okamura, J. Articles by Saburi, Y. Search for Related Content PubMed PubMed Citation Articles by Okamura, J. Articles by Saburi, Y. Related Collections Transplantation Immunotherapy Brief Reports Clinical Trials and Observations Neoplasia Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  TRANSPLANTATION Brief report Allogeneic stem-cell transplantation with reduced conditioning intensity as a novel immunotherapy and antiviral therapy for adult T-cell leukemia/lymphoma Jun Okamura, Atae Utsunomiya, Ryuji Tanosaki, Naokuni Uike, Shunro Sonoda, Mari Kannagi, Masao Tomonaga, Mine Harada, Nobuhiro Kimura, Masato Masuda, Fumio Kawano, Yuji Yufu, Hiroyoshi Hattori, Hiroshi Kikuchi, and Yoshio Saburi From the Institute for Clinical Research, National Kyushu Cancer Center, Fukuoka, Japan; Department of Hematology, Imamura Bun-in Hospital, Kagoshima, Japan; Stem Cell Transplantation Unit, National Cancer Center Hospital, Tokyo, Japan; Department of Hematology, National Kyushu Cancer Center, Fukuoka, Japan; Department of Virology, Faculty of Medicine, Kagoshima University, Kagoshima, Japan; Department of Immunotherapeutics, Tokyo Medical and Dental University, Medical Research Division, Tokyo, Japan; Department of Hematology, Molecular Medicine Unit, Atomic Bomb Disease Institute, Nagasaki University School of Medicine, Nagasaki, Japan; Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan; First Department of Internal Medicine, Fukuoka University, Fukuoka, Japan; Second Department of Internal Medicine, University of the Ryukyus, Okinawa, Japan; Institute for Clinical Research, Kumamoto National Hospital, Kumamoto, Japan; Blood Transfusion Service, Oita University, Faculty of Medicine, Oita, Japan; Department of Hematology, Oita Prefectural Hospital, Oita, Japan. Sixteen patients with adult T-cell leukemia/lymphoma (ATL) who were all over 50 years of age underwent allogeneic stem cell transplantation with reduced-conditioning intensity (RIST) from HLA-matched sibling donors after a conditioning regimen consisting of fludarabine (180 mg/m2), busulfan (8 mg/kg), and rabbit antithymocyte globulin (5 mg/kg). The observed regimen-related toxicities and nonhematologic toxicities were all found to be acceptable. Disease relapse was the main cause of treatment failure. Three patients who had a relapse subsequently responded to a rapid discontinuation of the immunosuppressive agent and thereafter achieved another remission. After RIST, the human T-cell leukemia virus type 1 (HTLV-1) proviral load became undetectable in 8 patients. RIST is thus considered to be a feasible treatment for ATL. Our data also suggest the presence of a possible graft-versus-ATL effect; an anti-HTLV-1 activity was also found to be associated with this procedure. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: S. Le Gouill, N. Milpied, A. Buzyn, R. Peffault De Latour, J.-P. Vernant, M. Mohty, M.-P. Moles, K. Bouabdallah, C.-E. Bulabois, J. Dupuis, et al. Graft-Versus-Lymphoma Effect for Aggressive T-Cell Lymphomas in Adults: A Study by the Societe Francaise de Greffe de Moelle et de Therapie Cellulaire J. Clin. Oncol., May 10, 2008; 26(14): 2264 - 2271. [Abstract] [Full Text] [PDF] E Matutes Adult T-cell leukaemia/lymphoma J. Clin. Pathol., December 1, 2007; 60(12): 1373 - 1377. [Abstract] [Full Text] [PDF] M. Matsuoka and K.-T. Jeang Human T-Cell Leukemia Virus Type I at Age 25: A Progress Report Cancer Res., June 1, 2005; 65(11): 4467 - 4470. [Abstract] [Full Text] [PDF]

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