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Blood, 1 June 2005, Vol. 105, No. 11, pp. 4200-4206. Prepublished online as a Blood First Edition Paper on February 8, 2005; DOI 10.1182/blood-2004-10-4023. This Article Full Text Full Text (PDF) All Versions of this Article: 2004-10-4023v1 105/11/4200    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Lee, S. J. Search for Related Content PubMed PubMed Citation Articles by Lee, S. J. Related Collections Immunobiology Transplantation Reviews in Translational Hematology Free Research Articles Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  REVIEW IN TRANSLATIONAL HEMATOLOGY New approaches for preventing and treating chronic graft-versus-host disease Stephanie J. Lee From the Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA. Abstract Despite improvements in the practice of allogeneic hematopoietic stem cell transplantation (HCT) over the last 25 years, chronic graft-versus-host disease (GVHD) remains a substantial problem with little change in the incidence, morbidity, and mortality of this complication. In fact, with increased use of peripheral blood, transplantation of older patients, and less immediate transplantation-related mortality, the prevalence of chronic GVHD may increase. One of the difficulties in combating chronic GVHD is a lack of understanding about the pathophysiology of the syndrome. Inherent difficulties in conducting human clinical trials also contribute to the lack of meaningful progress. This review covers potential new approaches to the prevention and treatment of chronic GVHD. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: J. Kim, K. Park, H. J. Kim, J. Kim, H.-A Kim, D. Jung, H. J. Kim, H.-J. Choi, S.-Y. Choi, K. W. Seo, et al. Breaking of CD8+ T Cell Tolerance through In Vivo Ligation of CD40 Results in Inhibition of Chronic Graft-versus-Host Disease and Complete Donor Cell Engraftment J. Immunol., November 15, 2008; 181(10): 7380 - 7389. [Abstract] [Full Text] [PDF] R. Kapur, S. Ebeling, and A. Hagenbeek B-cell involvement in chronic graft-versus-host disease Haematologica, November 1, 2008; 93(11): 1702 - 1711. [Abstract] [Full Text] [PDF] S. J. Lee and M. E. D. Flowers Recognizing and Managing Chronic Graft-Versus-Host Disease Hematology, January 1, 2008; 2008(1): 134 - 141. [Abstract] [Full Text] [PDF] S. Sarantopoulos, K. E. Stevenson, H. T. Kim, N. S. Bhuiya, C. S. Cutler, R. J. Soiffer, J. H. Antin, and J. Ritz High Levels of B-Cell Activating Factor in Patients with Active Chronic Graft-Versus-Host Disease Clin. Cancer Res., October 15, 2007; 13(20): 6107 - 6114. [Abstract] [Full Text] [PDF] J. Kim, H. J. Kim, K. Park, J. Kim, H.-J. Choi, H. Yagita, S. H. Nam, H. R. Cho, and B. Kwon Costimulatory molecule-targeted immunotherapy of cutaneous graft-versus-host disease Blood, July 15, 2007; 110(2): 776 - 782. [Abstract] [Full Text] [PDF] P. Niscola, C. Romani, L. Cupelli, L. Scaramucci, A. Tendas, T. Dentamaro, S. Amadori, and P. de Fabritiis Mucositis in patients with hematologic malignancies: an overview Haematologica, February 1, 2007; 92(2): 222 - 231. [Abstract] [Full Text] [PDF] C. Zhang, I. Todorov, Z. Zhang, Y. Liu, F. Kandeel, S. Forman, S. Strober, and D. Zeng Donor CD4+ T and B cells in transplants induce chronic graft-versus-host disease with autoimmune manifestations Blood, April 1, 2006; 107(7): 2993 - 3001. [Abstract] [Full Text] [PDF]

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