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Blood, 1 June 2005, Vol. 105, No. 11, pp. 4321-4329. Prepublished online as a Blood First Edition Paper on January 4, 2005; DOI 10.1182/blood-2004-07-2885. This Article Full Text Full Text (PDF) Supplemental Figure All Versions of this Article: 2004-07-2885v1 105/11/4321    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Conrotto, P. Articles by Giordano, S. Search for Related Content PubMed PubMed Citation Articles by Conrotto, P. Articles by Giordano, S. Related Collections Hemostasis, Thrombosis, and Vascular Biology Signal Transduction Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY Sema4D induces angiogenesis through Met recruitment by Plexin B1 Paolo Conrotto, Donatella Valdembri, Simona Corso, Guido Serini, Luca Tamagnone, Paolo Maria Comoglio, Federico Bussolino, and Silvia Giordano From the Divisions of Molecular Oncology and Molecular Angiogenesis, Department of Oncological Sciences, IRCC, Institute for Cancer Research and Treatment, University of Torino School of Medicine, Italy. Semaphorins, a large family of membrane-bound and secreted proteins, signal through their transmembrane receptors, the plexins. Semaphorins and plexins share structural homologies with scatter factor receptors, a family of tyrosine kinase receptors for which Met is the prototype. Semaphorins have been studied primarily in the developing nervous system, where they act as repelling cues in axon guidance. However, they are widely expressed in several tissues, and their role in epithelial morphogenesis has been recently established. Not much is known about their role in angiogenesis, a key step during embryonic development and adulthood. Here we demonstrate that a semaphorin, Sema4D, is angiogenic in vitro and in vivo and that this effect is mediated by its high-affinity receptor, Plexin B1. Moreover, we prove that biologic effects elicited by Plexin B1 require coupling and activation of the Met tyrosine kinase. In sum, we identify a proangiogenic semaphorin and provide insight about the signaling machinery exploited by Plexin B1 to control angiogenesis. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Novel paths to blood vessel formation Lena Claesson-Welsh Blood 2005 105: 4153-4154. [Full Text] [PDF] This article has been cited by other articles: J. R. Sierra, S. Corso, L. Caione, V. Cepero, P. Conrotto, A. Cignetti, W. Piacibello, A. Kumanogoh, H. Kikutani, P. M. Comoglio, et al. Tumor angiogenesis and progression are enhanced by Sema4D produced by tumor-associated macrophages J. Exp. Med., July 7, 2008; 205(7): 1673 - 1685. [Abstract] [Full Text] [PDF] G. Serini, L. Napione, M. Arese, and F. Bussolino Besides adhesion: new perspectives of integrin functions in angiogenesis Cardiovasc Res, May 1, 2008; 78(2): 213 - 222. [Abstract] [Full Text] [PDF] L. F. Brass, L. Zhu, and T. J. Stalker Novel Therapeutic Targets at the Platelet Vascular Interface Arterioscler. Thromb. Vasc. Biol., March 1, 2008; 28(3): s43 - s50. [Abstract] [Full Text] [PDF] S. Deng, A. Hirschberg, T. Worzfeld, J. Y. Penachioni, A. Korostylev, J. M. Swiercz, P. Vodrazka, O. Mauti, E. T. Stoeckli, L. Tamagnone, et al. Plexin-B2, But Not Plexin-B1, Critically Modulates Neuronal Migration and Patterning of the Developing Nervous System In Vivo J. Neurosci., June 6, 2007; 27(23): 6333 - 6347. [Abstract] [Full Text] [PDF] T. Fujikawa, H. Shiraha, N. Ueda, N. Takaoka, Y. Nakanishi, N. Matsuo, S. Tanaka, S.-i. Nishina, M. Suzuki, A. Takaki, et al. Des-{gamma}-carboxyl Prothrombin-promoted Vascular Endothelial Cell Proliferation and Migration J. Biol. Chem., March 23, 2007; 282(12): 8741 - 8748. [Abstract] [Full Text] [PDF] J. R. Basile, K. Holmbeck, T. H. Bugge, and J. S. Gutkind MT1-MMP Controls Tumor-induced Angiogenesis through the Release of Semaphorin 4D J. Biol. Chem., March 2, 2007; 282(9): 6899 - 6905. [Abstract] [Full Text] [PDF] A. Rody, U. Holtrich, R. Gaetje, M. Gehrmann, K. Engels, G. von Minckwitz, S. Loibl, R. Diallo-Danebrock, E. Ruckhaberle, D. Metzler, et al. Poor Outcome in Estrogen Receptor-Positive Breast Cancers Predicted by Loss of Plexin B1 Clin. Cancer Res., February 15, 2007; 13(4): 1115 - 1122. [Abstract] [Full Text] [PDF] L. Zhu, W. Bergmeier, J. Wu, H. Jiang, T. J. Stalker, M. Cieslak, R. Fan, L. Boumsell, A. Kumanogoh, H. Kikutani, et al. Regulated surface expression and shedding support a dual role for semaphorin 4D in platelet responses to vascular injury PNAS, January 30, 2007; 104(5): 1621 - 1626. [Abstract] [Full Text] [PDF] J. R. Basile, R. M. Castilho, V. P. Williams, and J. S. Gutkind Semaphorin 4D provides a link between axon guidance processes and tumor-induced angiogenesis PNAS, June 13, 2006; 103(24): 9017 - 9022. [Abstract] [Full Text] [PDF] V. Potiron and J. Roche Class 3 Semaphorin Signaling: The End of a Dogma Sci. Signal., May 24, 2005; 2005(285): pe24 - pe24. [Abstract] [Full Text] [PDF]

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