SEARCH:   Advanced

Blood, 1 June 2005, Vol. 105, No. 11, pp. 4416-4423. Prepublished online as a Blood First Edition Paper on February 22, 2005; DOI 10.1182/blood-2004-08-3156. This Article Full Text Full Text (PDF) Supplemental Figures All Versions of this Article: 2004-08-3156v1 105/11/4416    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Fernandez, N. C. Articles by Raulet, D. H. Search for Related Content PubMed PubMed Citation Articles by Fernandez, N. C. Articles by Raulet, D. H. Related Collections Transplantation Immunobiology Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY A subset of natural killer cells achieves self-tolerance without expressing inhibitory receptors specific for self-MHC molecules Nadine C. Fernandez, Emmanuel Treiner, Russell E. Vance, Amanda M. Jamieson, Suzanne Lemieux, and David H. Raulet From the Department of Molecular and Cell Biology and Cancer Research Laboratory, University of California, Berkeley; and the Institut National de la Recherche Scientifique–Institut Armand Frappier, Université du Québec, Laval, QC, Canada. It is widely believed that self-tolerance of natural killer (NK) cells occurs because each NK cell expresses at least one inhibitory receptor specific for a host major histocompatibility complex (MHC) class I molecule. Here we report that some NK cells lack all known self-MHC–specific inhibitory receptors, yet are nevertheless self-tolerant. These NK cells exhibit a normal cell surface phenotype and some functional activity. However, they respond poorly to class I–deficient normal cells, tumor cells, or cross-linking of stimulatory receptors, suggesting that self-tolerance is established by dampening stimulatory signaling. Thus, self-tolerance of NK cells in normal animals can occur independently of MHC-mediated inhibition, and hyporesponsiveness plays a role in self-tolerance of NK cells, as also proposed for B and T cells. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: M.-C. Zhong and A. Veillette Control of T Lymphocyte Signaling by Ly108, a Signaling Lymphocytic Activation Molecule Family Receptor Implicated in Autoimmunity J. Biol. Chem., July 11, 2008; 283(28): 19255 - 19264. [Abstract] [Full Text] [PDF] J. C. Sun and L. L. Lanier Tolerance of NK cells encountering their viral ligand during development J. Exp. Med., July 7, 2008; (2008) jem.20072448. [Abstract] [Full Text] [PDF] A. Iannello, O. Debbeche, S. Samarani, and A. Ahmad Antiviral NK cell responses in HIV infection: I. NK cell receptor genes as determinants of HIV resistance and progression to AIDS J. Leukoc. Biol., July 1, 2008; 84(1): 1 - 26. [Abstract] [Full Text] [PDF] A. W. MacFarlane IV, T. Yamazaki, M. Fang, L. J. Sigal, T. Kurosaki, and K. S. Campbell Enhanced NK-cell development and function in BCAP-deficient mice Blood, July 1, 2008; 112(1): 131 - 140. [Abstract] [Full Text] [PDF] S. Kim, J. B. Sunwoo, L. Yang, T. Choi, Y.-J. Song, A. R. French, A. Vlahiotis, J. F. Piccirillo, M. Cella, M. Colonna, et al. HLA alleles determine differences in human natural killer cell responsiveness and potency PNAS, February 26, 2008; 105(8): 3053 - 3058. [Abstract] [Full Text] [PDF] Y. Hayakawa, S. V. Watt, K. Takeda, and M. J. Smyth Distinct receptor repertoire formation in mouse NK cell subsets regulated by MHC class I expression J. Leukoc. Biol., January 1, 2008; 83(1): 106 - 111. [Abstract] [Full Text] [PDF] S. Santourlidis, N. Graffmann, J. Christ, and M. Uhrberg Lineage-Specific Transition of Histone Signatures in the Killer Cell Ig-Like Receptor Locus from Hematopoietic Progenitor to NK Cells J. Immunol., January 1, 2008; 180(1): 418 - 425. [Abstract] [Full Text] [PDF] J. Yu, G. Heller, J. Chewning, S. Kim, W. M. Yokoyama, and K. C. Hsu Hierarchy of the Human Natural Killer Cell Response Is Determined by Class and Quantity of Inhibitory Receptors for Self-HLA-B and HLA-C Ligands J. Immunol., November 1, 2007; 179(9): 5977 - 5989. [Abstract] [Full Text] [PDF] S. Malarkannan, J. Regunathan, H. Chu, S. Kutlesa, Y. Chen, H. Zeng, R. Wen, and D. Wang Bcl10 Plays a Divergent Role in NK Cell-Mediated Cytotoxicity and Cytokine Generation J. Immunol., September 15, 2007; 179(6): 3752 - 3762. [Abstract] [Full Text] [PDF] Y. T. Bryceson, E. Rudd, C. Zheng, J. Edner, D. Ma, S. M. Wood, A. G. Bechensteen, J. J. Boelens, T. Celkan, R. A. Farah, et al. Defective cytotoxic lymphocyte degranulation in syntaxin-11 deficient familial hemophagocytic lymphohistiocytosis 4 (FHL4) patients Blood, September 15, 2007; 110(6): 1906 - 1915. [Abstract] [Full Text] [PDF] J. H. Chewning, C. N. Gudme, K. C. Hsu, A. Selvakumar, and B. Dupont KIR2DS1-Positive NK Cells Mediate Alloresponse against the C2 HLA-KIR Ligand Group In Vitro J. Immunol., July 15, 2007; 179(2): 854 - 868. [Abstract] [Full Text] [PDF] S. Cooley, F. Xiao, M. Pitt, M. Gleason, V. McCullar, T. L. Bergemann, K. L. McQueen, L. A. Guethlein, P. Parham, and J. S. Miller A subpopulation of human peripheral blood NK cells that lacks inhibitory receptors for self-MHC is developmentally immature Blood, July 15, 2007; 110(2): 578 - 586. [Abstract] [Full Text] [PDF] L. Ruggeri, A. Mancusi, M. Capanni, E. Urbani, A. Carotti, T. Aloisi, M. Stern, D. Pende, K. Perruccio, E. Burchielli, et al. Donor natural killer cell allorecognition of missing self in haploidentical hematopoietic transplantation for acute myeloid leukemia: challenging its predictive value. Blood, July 1, 2007; 110(1): 433 - 440. [Abstract] [Full Text] [PDF] C. Romagnani, K. Juelke, M. Falco, B. Morandi, A. D'Agostino, R. Costa, G. Ratto, G. Forte, P. Carrega, G. Lui, et al. CD56brightCD16- Killer Ig-Like Receptor- NK Cells Display Longer Telomeres and Acquire Features of CD56dim NK Cells upon Activation J. Immunol., April 15, 2007; 178(8): 4947 - 4955. [Abstract] [Full Text] [PDF] J. C. Fischer, H. Ottinger, S. Ferencik, M. Sribar, M. Punzel, D. W. Beelen, M. A. Schwan, H. Grosse-Wilde, P. Wernet, and M. Uhrberg Relevance of C1 and C2 Epitopes for Hemopoietic Stem Cell Transplantation: Role for Sequential Acquisition of HLA-C-Specific Inhibitory Killer Ig-Like Receptor J. Immunol., March 15, 2007; 178(6): 3918 - 3923. [Abstract] [Full Text] [PDF] X. Xie, A. Dighe, P. Clark, P. Sabastian, S. Buss, and M. G. Brown Deficient Major Histocompatibility Complex-Linked Innate Murine Cytomegalovirus Immunity in MA/My.L-H2b Mice and Viral Downregulation of H-2k Class I Proteins J. Virol., January 1, 2007; 81(1): 229 - 236. [Abstract] [Full Text] [PDF] B. Grzywacz, N. Kataria, M. Sikora, R. A. Oostendorp, E. A. Dzierzak, B. R. Blazar, J. S. Miller, and M. R. Verneris Coordinated acquisition of inhibitory and activating receptors and functional properties by developing human natural killer cells Blood, December 1, 2006; 108(12): 3824 - 3833. [Abstract] [Full Text] [PDF] J. Regunathan, Y. Chen, S. Kutlesa, X. Dai, L. Bai, R. Wen, D. Wang, and S. Malarkannan Differential and Nonredundant Roles of Phospholipase C{gamma}2 and Phospholipase C{gamma}1 in the Terminal Maturation of NK Cells J. Immunol., October 15, 2006; 177(8): 5365 - 5376. [Abstract] [Full Text] [PDF] R. Bhat, P. Eissmann, J. Endt, S. Hoffmann, and C. Watzl Fine-tuning of immune responses by SLAM-related receptors J. Leukoc. Biol., March 1, 2006; 79(3): 417 - 424. [Abstract] [Full Text] [PDF] S. Stark and C. Watzl 2B4 (CD244), NTB-A and CRACC (CS1) stimulate cytotoxicity but no proliferation in human NK cells Int. Immunol., February 1, 2006; 18(2): 241 - 247. [Abstract] [Full Text] [PDF] H. Aldemir, V. Prod'homme, M.-J. Dumaurier, C. Retiere, G. Poupon, J. Cazareth, F. Bihl, and V. M. Braud Cutting Edge: Lectin-Like Transcript 1 Is a Ligand for the CD161 Receptor J. Immunol., December 15, 2005; 175(12): 7791 - 7795. [Abstract] [Full Text] [PDF] Y. T. Bryceson, M. E. March, D. F. Barber, H.-G. Ljunggren, and E. O. Long Cytolytic granule polarization and degranulation controlled by different receptors in resting NK cells J. Exp. Med., October 3, 2005; 202(7): 1001 - 1012. [Abstract] [Full Text] [PDF] F. Gays, K. Martin, R. Kenefeck, J. G. Aust, and C. G. Brooks Multiple Cytokines Regulate the NK Gene Complex-Encoded Receptor Repertoire of Mature NK Cells and T Cells J. Immunol., September 1, 2005; 175(5): 2938 - 2947. [Abstract] [Full Text] [PDF] M. E. McNerney, D. Guzior, and V. Kumar 2B4 (CD244)-CD48 interactions provide a novel MHC class I-independent system for NK-cell self-tolerance in mice Blood, August 15, 2005; 106(4): 1337 - 1340. [Abstract] [Full Text] [PDF]

	Blood Online is supported in part by Genentech BioOncology and Biogen Idec
	Copyright © 2005 by American Society of Hematology         Online ISSN: 1528-0020