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Blood, 15 June 2005, Vol. 105, No. 12, pp. 4649-4656.
Prepublished online as a Blood First Edition Paper on February 10, 2005; DOI 10.1182/blood-2004-08-3382.
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HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
Angiopoietin-1 promotes LYVE-1-positive lymphatic vessel formation
Tohru Morisada,
Yuichi Oike,
Yoshihiro Yamada,
Takashi Urano,
Masaki Akao,
Yoshiaki Kubota,
Hiromitsu Maekawa,
Yoshishige Kimura,
Masako Ohmura,
Takeshi Miyamoto,
Shiro Nozawa,
Gou Young Koh,
Kari Alitalo, and
Toshio Suda
From the Department of Cell Differentiation, The Sakaguchi Laboratory, Department of Obstetrics and Gynecology, School of Medicine, Keio University, Tokyo, Japan; Biomedical Research Center and Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea; and Molecular/Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Biomedicum Helsinki and Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland.
Angiopoietin (Ang) signaling plays a role in angiogenesis and remodeling of blood vessels through the receptor tyrosine kinase Tie2, which is expressed on blood vessel endothelial cells (BECs). Recently it has been shown that Ang-2 is crucial for the formation of lymphatic vasculature and that defects in lymphangiogenesis seen in Ang-2 mutant mice are rescued by Ang-1. These findings suggest important roles for Ang signaling in the lymphatic vessel system; however, Ang function in lymphangiogenesis has not been characterized. In this study, we reveal that lymphatic vascular endothelial hyaluronan receptor 1-positive (LYVE-1+) lymphatic endothelial cells (LECs) express Tie2 in both embryonic and adult settings, indicating that Ang signaling occurs in lymphatic vessels. Therefore, we examined whether Ang-1 acts on in vivo lymphatic angiogenesis and in vitro growth of LECs. A chimeric form of Ang-1, cartilage oligomeric matrix protein (COMP)-Ang-1, promotes in vivo lymphatic angiogenesis in mouse cornea. Moreover, we found that COMP-Ang-1 stimulates in vitro colony formation of LECs. These Ang-1-induced in vivo and in vitro effects on LECs were suppressed by soluble Tie2-Fc fusion protein, which acts as an inhibitor by sequestering Ang-1. On the basis of these observations, we propose that Ang signaling regulates lymphatic vessel formation through Tie2. (Blood. 2005;105:4649-4656)
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